Results 1 to 10 of about 34,994 (236)

377 FGFR protein phosphorylation as a biomarker for FGFR-targeted therapy in cholangiocarcinoma [PDF]

Journal of Clinical and Translational Science
Objectives/Goals: Cholangiocarcinoma is an aggressive cancer with a poor prognosis. Fibroblast Growth Factor Receptor 2 fusions are therapeutic targets in ~20% of cholangiocarcinoma, which restricts their benefit to only a subset of patients.
Zachary Risch, Julie Reeser, Michele Wing, Amy Smith, Thuy Dao, Eric Samorodnitsky, Emanuel Petricoin, Sameek Roychowdhury   +7 more
doaj   +3 more sources

Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

Cells, 2021
FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological ...
Patrycja Szybowska, Michal Kostas, Jørgen Wesche, Ellen Margrethe Haugsten, Antoni Wiedlocha   +4 more
doaj   +2 more sources

Targeting FGFR Pathways in Gastrointestinal Cancers: New Frontiers of Treatment

Biomedicines, 2023
In carcinogenesis of the gastrointestinal (GI) tract, the deregulation of fibroblast growth factor receptor (FGFR) signaling plays a critical role.
Michele Ghidini, Elena Orlandi, Stefano Vecchia   +2 more
exaly   +3 more sources

Recent Advances in Tumor Therapy Targeting FGFR

Zhongliu Fangzhi Yanjiu, 2022
Abnormal FGFR signaling has been found in a variety of cancers. The abnormal FGFR signaling is involved in several processes of tumorigenesis which include cell survival, proliferation, inflammation, migration, angiogenesis, epithelial-mesenchymal ...
ZHANG Jing, WANG Chen, GU Baohong, ZHANG Yaqing, CHEN Hao   +4 more
doaj   +1 more source

FGFR/RACK1 interacts with MDM2, promotes P53 degradation, and inhibits cell senescence in lung squamous cell carcinoma

Cancer Biology & Medicine, 2021
Objective: FGFR is considered an important driver gene of lung squamous cell carcinoma (LSCC). Thus, identification of the biological events downstream of FGFR is important for the treatment of this malignancy.
Tao Chen, Fei Wang, Shupei Wei, Yingjie Nie, Xiaotao Zheng, Yu Deng, Xubin Zhu, Yuezhen Deng, Nanshan Zhong, Chengzhi Zhou   +9 more
doaj   +1 more source

Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases

Cancer Biology & Medicine, 2021
Objective: Dysfunction in fibroblast growth factor receptor (FGFR) signaling has been reported in diverse cancer types, including non-small cell lung cancer (NSCLC).
Zhen Zhou, Zichuan Liu, Qiuxiang Ou, Xue Wu, Xiaonan Wang, Yang Shao, Hongyan Liu, Yu Yang   +7 more
doaj   +1 more source

Favorable Outcomes in FGFR Fusion-Positive Cholangiocarcinomas and Evolution on Treatment Noted on Circulating Tumor DNA Liquid Biopsies

Case Reports in Oncology, 2020
Cholangiocarcinoma is a very heterogenous cancer and “target-rich” disease. While the current classifications are based on the anatomic location of these tumors (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer ...
Pashtoon Murtaza Kasi
doaj   +1 more source

Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment

Molecular Cancer, 2023
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) play a crucial role in cell fate and angiogenesis, with dysregulation of the signaling axis driving tumorigenesis. Therefore, many studies have targeted FGF/FGFR signaling for cancer
Ruiwen Ruan, Li Li, Xuan Li, Chunye Huang, Zhanmin Zhang, Hongguang Zhong, Shaocheng Zeng, Qianqian Shi, Yang Xia, Qinru Zeng, Qin Wen, Jingyi Chen, Xiaofeng Dai, Jianping Xiong, Xiaojun Xiang, Wan Lei, Jun Deng   +16 more
doaj   +1 more source

Fibroblast growth factor receptor fusions in cancer: opportunities and challenges

Journal of Experimental & Clinical Cancer Research, 2021
Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many biological processes and developmental functions. Chromosomal translocation of FGFRs result in the formation of chimeric FGFR fusion proteins, which often cause ...
Lingfeng Chen, Yanmei Zhang, Lina Yin, Binhao Cai, Ping Huang, Xiaokun Li, Guang Liang   +6 more
doaj   +1 more source

Fibroblast growth factor receptor-2 expression in thyroid tumor progression: potential diagnostic application. [PDF]

PLoS ONE, 2013
Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified.
Adriano Redler, Giorgio Di Rocco, Domenico Giannotti, Francesca Frezzotti, Maria Giulia Bernieri, Simona Ceccarelli, Sirio D'Amici, Enrica Vescarelli, Anna Paola Mitterhofer, Antonio Angeloni, Cinzia Marchese   +10 more
doaj   +1 more source