Results 1 to 10 of about 32,832 (202)

Altered Fibroblast Growth Factor Receptor 4 Stability Promotes Prostate Cancer Progression

Neoplasia: An International Journal for Oncology Research, 2008
Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous.
Jianghua Wang, Wendong Yu, Yi Cai, Chengxi Ren, Michael M. Ittmann   +4 more
doaj   +1 more source

FGFR allosteric inhibition [PDF]

Science-Business eXchange, 2013
Sanofi and Flanders Institute for Biotechnology researchers have discovered a molecule that inhibits FGFR allosterically instead of orthosterically. The pharma is developing analogs of the inhibitor for cancer.
openaire   +1 more source

Roles of FGFR in oral carcinogenesis [PDF]

Cell Proliferation, 2016
AbstractFibroblast growth factor receptors (FGFRs) play essential roles in organ development during the embryonic period, and regulate tissue repair in adults. Accumulating evidence suggests that alterations in FGFR signalling are involved in diverse types of cancer.
Xiaoyan, Xie, Zhiyong, Wang, Fangman, Chen, Yao, Yuan, Jiayi, Wang, Rui, Liu, Qianming, Chen   +6 more
openaire   +2 more sources

FGFR2-fusions define a clinically actionable molecular subset of pancreatic cancer

npj Precision Oncology
Genomic alterations in fibroblast growth factor receptor (FGFR) genes are present in a small number of metastatic pancreatic ductal adenocarcinomas (PDAC) and may represent an emerging subgroup of patients likely to benefit from FGFR targeted therapies ...
Leah Stein, Karthikeyan Murugesan, Julie W. Reeser, Zachary Risch, Michele R. Wing, Anoosha Paruchuri, Eric Samorodnitsky, Emily L. Hoskins, Thuy Dao, Amy Smith, Dat Le, Melissa A. Babcook, Yi Seok Chang, Matthew R. Avenarius, Muhammad Imam, Aharon G. Freud, Sameek Roychowdhury   +16 more
doaj   +1 more source

Histological features in pediatric central nervous system tumors with FGFR alterations

Folia Neuropathologica, 2021
Ahmed Gilani, Kurtis Davies, Bette Kleinschmidt-DeMasters   +2 more
doaj   +1 more source

Targeting FGFR pathway in breast cancer

The Breast, 2018
Developments in breast cancer biology over the last years have permitted deconstructing the molecular profile of the most relevant breast cancer subtypes. This has led to an increase in therapeutic options, including more effective personalized therapy for breast cancer and substantial improvements in patient outcomes. Although currently there are only
J, Perez-Garcia, E, Muñoz-Couselo, J, Soberino, F, Racca, J, Cortes   +4 more
openaire   +2 more sources

FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer

Journal of Experimental & Clinical Cancer Research, 2019
Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine therapy.
Dominika Piasecka, Marcin Braun, Kamila Kitowska, Kamil Mieczkowski, Radzislaw Kordek, Rafal Sadej, Hanna Romanska   +6 more
doaj   +1 more source

The FGFR inhibitor Rogaratinib reduces microglia reactivity and synaptic loss in TBI

Frontiers in Immunology
BackgroundTraumatic brain injury (TBI) induces an acute reactive state of microglia, which contribute to secondary injury processes through phagocytic activity and release of cytokines.
Rida Rehman, Rida Rehman, Albrecht Froehlich, Florian olde Heuvel, Lobna Elsayed, Tobias Boeckers, Tobias Boeckers, Markus Huber-Lang, Cristina Morganti-Kossmann, Cristina Morganti-Kossmann, Francesco Roselli, Francesco Roselli   +11 more
doaj   +1 more source

The Role of Fibroblast Growth Factor Receptors Inhibitors in Bladder Cancer [PDF]

Journal of Urologic Oncology
Dysregulation of fibroblast growth factor (FGF)-receptor (FGFR) signaling, which is implicated in various oncogenic processes, including tumor proliferation, survival, migration, invasion, and angiogenesis, has been identified as a critical factor in ...
Ho Kyung Seo, Eui Hyun Jung, Sora Yang, Hye Won Lee   +3 more
doaj   +1 more source

Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.

PLoS ONE, 2014
BackgroundFibroblast growth factor receptor (FGFR) gene amplification has been reported in different types of cancer. We performed an up-to-date meta-analysis to further characterize the prognostic value of FGFR gene amplification in patients with cancer.
Jinjia Chang, Xinyang Liu, Shanshan Wang, Zhe Zhang, Zheng Wu, Xiaowei Zhang, Jin Li   +6 more
doaj   +1 more source