Results 1 to 10 of about 79,213 (303)

Cholangiocarcinoma [PDF]

Critical Reviews in Oncology/Hematology, 2017
Biliary tract cancer accounts for 
Michela, Squadroni, Luca, Tondulli, Gemma, Gatta, Stefania, Mosconi, Giordano, Beretta, Roberto, Labianca   +5 more
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Cholangiocarcinoma [PDF]

Nature Reviews Disease Primers, 2021
Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has distinct genetic aberrations, clinical presentations and therapeutic approaches.
Paul J. Brindley, Melinda Bachini, Sumera I. Ilyas, Shahid A. Khan, Alex Loukas, Alphonse E. Sirica, Bin Tean Teh, Sopit Wongkham, Gregory J. Gores   +8 more
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Chemotherapeutic resistant cholangiocarcinoma displayed distinct intratumoral microbial composition and metabolic profiles [PDF]

PeerJ, 2022
Background Cholangiocarcinoma (CCA) is a malignancy of the cholangiocytes. One of the major issues regarding treatment for CCA patients is the development of chemotherapeutic resistance.
Sirinya Sitthirak, Manida Suksawat, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Poramate Klanrit, Nisana Namwat, Narong Khuntikeo, Attapol Titapun, Apiwat Jarearnrat, Sakkarn Sangkhamanon, Watcharin Loilome   +10 more
doaj   +2 more sources

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells [PDF]

PeerJ, 2023
Background Niclosamide is an oral anthelminthic drug that has been used for treating tapeworm infections. Its mechanism involves the disturbance of mitochondrial membrane potential that in turn inhibits oxidative phosphorylation leading to ATP depletion.
Thanaporn Kulthawatsiri, Yingpinyapat Kittirat, Jutarop Phetcharaburanin, Jittima Tomacha, Bundit Promraksa, Arporn Wangwiwatsin, Poramate Klanrit, Attapol Titapun, Watcharin Loilome, Nisana Namwat   +9 more
doaj   +2 more sources

1H NMR fecal metabolic phenotyping of periductal fibrosis- and cholangiocarcinoma-specific metabotypes defining perturbation in gut microbial-host co-metabolism [PDF]

PeerJ, 2023
Background The liver fluke Opisthorchis viverrini (OV), which subsequently inhabits the biliary system and results in periductal fibrosis (PDF), is one of the primarily causes of cholangiocarcinoma (CCA), a bile duct cancer with an exceptionally high ...
Rujikorn Treeriya, Phuc N. Ho, Attapol Titapun, Poramate Klanrit, Manida Suksawat, Thanaporn Kulthawatsiri, Suphasarang Sirirattanakul, Watcharin Loilome, Nisana Namwat, Arporn Wangwiwatsin, Nittaya Chamadol, Narong Khuntikeo, Jutarop Phetcharaburanin   +12 more
doaj   +2 more sources

Cholangiocarcinoma [PDF]

The Lancet, 2014
Cholangiocarcinoma represents a diverse group of epithelial cancers united by late diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are undertaken for cholangiocarcinomas of different anatomical locations (intrahepatic, perihilar, and distal).
Razumilava, Nataliya, Gores, Gregory J
openaire   +2 more sources

APOBEC3 activity and DNA polymerase-ε deficiency are associated with distinct IDH1 R132 hotspot mutations. [PDF]

Mol Oncol
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Butler KE, Lone BA, Unal E, Banday AR.
europepmc   +2 more sources

Locoregional Treatments in Cholangiocarcinoma and Combined Hepatocellular Cholangiocarcinoma [PDF]

Cancers, 2021
Cholangiocarcinoma (CCA) is a primary and aggressive cancer of the biliary tree. Combined hepatocellular cholangiocarcinoma (CHC) is a distinctive primary liver malignancy which has properties of both hepatocytic and cholangiocytic differentiation.
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolò Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri   +9 more
openaire   +4 more sources

Accuracy of a new rapid diagnostic test for urinary antigen detection and assessment of drug treatment in opisthorchiasis

Infectious Diseases of Poverty, 2023
Background Screening for opisthorchiasis, a parasitic worm infection affecting many millions of people in Southeast Asia, has traditionally relied on faecal egg examination such as the formalin-ethyl acetate concentration technique (FECT) and Kato-Katz ...
Chanika Worasith, Jiraporn Sithithaworn, Phattharaphon Wongphutorn, Chutima Homwong, Kanoknan Khongsukwiwat, Anchalee Techasen, Kulthida Y. Kopolrat, Watcharin Loilome, Nisana Namwat, Bandit Thinkamrop, Chaiwat Tawarungruang, Attapol Titapun, Thewarach Laha, Ross H. Andrews, Simon D. Taylor-Robinson, Paiboon Sithithaworn   +15 more
doaj   +1 more source

Facial Swelling as a Presenting Sign of Cholangiocarcinoma [PDF]

, 2022
Cholangiocarcinoma is a rare primary malignancy of the biliary tree, which usually presents late in the course of disease with jaundice, upper right quadrant pain, and cachexia. They frequently metastasise in the lungs, liver, bones, adrenals, peritoneum,
Nagireddy Bethireddy, Sanjay M. Khaladkar, Darshana Dilip, Purnachandra Lamghare, Vijetha Chanabasanavar   +4 more
core   +1 more source