Results 21 to 30 of about 71,118 (301)

Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein

Integrative Cancer Therapies, 2022
Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS, Piman Pocasap PhD, Veerapol Kukongviriyapan PhD, Auemduan Prawan PhD, Sarinya Kongpetch PhD, Laddawan Senggunprai PhD   +5 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression

Frontiers in Pharmacology, 2021
An aberrant regulation of lipid metabolism is involved in the pathogenesis and progression of cancer. Up-regulation of lipid biosynthesis enzymes, including acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN) and HMG-CoA reductase (HMGCR), has been ...
Jittima Tomacha, Jittima Tomacha, Hasaya Dokduang, Sureerat Padthaisong, Nisana Namwat, Nisana Namwat, Poramate Klanrit, Poramate Klanrit, Jutarop Phetcharaburanin, Jutarop Phetcharaburanin, Arporn Wangwiwatsin, Arporn Wangwiwatsin, Tueanjit Khampitak, Supinda Koonmee, Supinda Koonmee, Attapol Titapun, Attapol Titapun, Apiwat Jarearnrat, Apiwat Jarearnrat, Narong Khuntikeo, Narong Khuntikeo, Watcharin Loilome, Watcharin Loilome   +22 more
doaj   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Curcumin-loaded nanocomplexes alleviate the progression of fluke-related cholangiocarcinoma in hamsters

Cancer Nanotechnology, 2023
Background Curcumin-loaded nanocomplexes (CNCs) previously demonstrated lower toxicity and extended release better than is the case for free curcumin. Here, we evaluated the efficacy of CNCs against opisthorchiasis-associated cholangiocarcinoma (CCA) in ...
Chanakan Jantawong, Yaovalux Chamgramol, Kitti Intuyod, Aroonsri Priprem, Chawalit Pairojkul, Sirinapha Klungsaeng, Rungtiwa Dangtakot, Thatsanapong Pongking, Chutima Sitthirach, Porntip Pinlaor, Sakda Waraasawapati, Somchai Pinlaor   +11 more
doaj   +1 more source

Capecitabine as second-line treatment for metastatic cholangiocarcinoma: A report of two cases [PDF]

, 2002
Background: The management of recurrent, metastatic cholangiocarcinoma still remains a problem since this tumor entity is classified as chemotherapy-resistant.
Schalhorn, A., Stemmler, Joachim, Heinemann, Volker   +2 more
core   +1 more source

Epigenetic alterations associated with cholangiocarcinoma (Review) [PDF]

, 2009
Cholangiocarcinoma (CCA) is a highly lethal malignant tumor arising from the biliary tract epithelium. Chronic inflammatory conditions, including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis, are considered risk factors ...
Isomoto, Hajime
core   +1 more source

Survival after surgery among patients with cholangiocarcinoma in Northeast Thailand according to anatomical and morphological classification

BMC Cancer, 2021
Background Cholangiocarcinoma (CCA) has been categorized based on tumor location as intrahepatic (ICCA), perihilar (PCCA) or distal (DCCA), and based on the morphology of the tumor of the bile duct as mass forming (MF), periductal infiltrating (PI) or ...
Chaiwat Tawarungruang, Narong Khuntikeo, Nittaya Chamadol, Vallop Laopaiboon, Jaruwan Thuanman, Kavin Thinkhamrop, Matthew Kelly, Bandit Thinkhamrop   +7 more
doaj   +1 more source

Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma [PDF]

, 2023
Background: Most data on the treatment and outcomes of intrahepatic cholangiocarcinoma (iCCA) derives from expert centers. This study aimed to investigate the treatment and outcomes of all patients diagnosed with iCCA in a nationwide cohort.
Dutch Hepatocellular & Cholangiocarcinoma Group (DHCG)
core