Results 41 to 50 of about 34,994 (236)
Bilateral Subretinal Fluid Accumulation during Erdafitinib Therapy
TNOA Journal of Ophthalmic Science and ResearchFibroblast growth factor receptor (FGFR) plays a major role in maintaining retinal pigment epithelium cells. Drugs that inhibit the FGFR pathway block the activation of the mitogen-activated protein kinase pathway, leading to the synthesis of ...
Rajneesh Singh +3 more
doaj +1 more source
Multifocal serous retinopathy with pemigatinib therapy for metastatic colon adenocarcinoma
International Journal of Retina and Vitreous, 2021 Background Pemigatinib is an inhibitor of the fibroblast growth factor receptor (FGFR), recently approved for the treatment of cholangiocarcinoma. FGFR retinopathy is a newly recognized entity, with only two other FGFR inhibitors reported to cause serous
Oleg Alekseev, Effy Ojuok, Scott Cousins
doaj +1 more source
MET-Pyk2 Axis Mediates Acquired Resistance to FGFR Inhibition in Cancer Cells
Frontiers in Oncology, 2021 Deregulation of fibroblast growth factor receptors (FGFRs) signaling, as a result of FGFR amplification, chromosomal translocation, or mutations, is involved in both initiation and progression of a wide range of human cancers. Clinical data demonstrating
Kamila Kitowska +10 more
doaj +1 more source
Paths of FGFR-driven tumorigenesis [PDF]
Cell Cycle, 2009 Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration and angiogenesis. Due to their broad impact, FGFRs and other RTKs are highly regulated and normally only basally active.
Victor D, Acevedo +2 more
openaire +2 more sources
FGFR-2, FGFR-2-IIIb and FGFR-2-IIIc mRNA expression in thyroid cancer progression.
, 2013 (A) Quantitative Real-Time PCR analysis of FGFR-2-IIIb mRNA expression in normal thyroid tissue, hyperplastic thyroid tissue, follicular adenoma and papillary carcinoma. Relative FGFR-2-IIIb mRNA levels are shown as fold value of the level of FGFR-2-IIIb
Giorgio Di Rocco (382578) +10 more
core +1 more source
, 2015 Bar diagram showing fold change expression of FGF-2, FGFR-2 and FGFR-3 by Real Time. A, PCR in OSMF, LKP, OSCC and healthy controls. B, Frequency of FGF-2 malignant transformation rate in PMOLs.
Vikram Bhatia (406012) +6 more
core +1 more source
Biomolecules, 2022 Recently, FGFR inhibitors have been highlighted as promising targeted drugs due to the high prevalence of FGFR1 amplification in cancer patients. Although various potential biomarkers for FGFR inhibitors have been suggested, their functional effects have
Jonghoon Lee +2 more
doaj +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]
PLoS ONE, 2012 Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue +6 more
doaj +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source