Results 41 to 50 of about 35,836 (258)
Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling
Cells, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson +2 more
doaj +1 more source
Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer [PDF]
, 2010 Breast cancer, the main cancer in women, occurs in approximately 27% of all yearly diagnosed cancer cases. It is estimated that one out of eight women will develop breast cancer in her lifetime.
Dey, Julien Hervé
core +1 more source
Cancer Management and Research, 2021 Changlin Mao,1 Wei Dong,2 Jiaju Lu,3 Zhao Zhang,4 Hongliang Wu,5 Armin Ghavamian,1 Dongbin Bi,3 Pei Gao,1 Zhao Liu,5 Sentai Ding1,3 1Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong ...
Mao C +9 more
doaj
BMC Cancer, 2022 Background Mutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10–20% of metastatic urothelial carcinomas and confer sensitivity to FGFR inhibitors. However, responses to these agents are often short-lived due to the development
Andrew J. Weickhardt +8 more
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INCB054828 inhibits FGFR-dependent signaling pathways.
, 2020 (A) KG1a or (B) RT-4 cells were treated with INCB054828 for 2 hours, lysed and subjected to immunoblotting for phospho- and total proteins in the FGFR signal transduction pathway including FGFR, ERK, FRS2, and STAT5.
Kevin Bowman (5435744) +26 more
core +1 more source
Supplementary Table 2 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 Systemic treatment received by patients prior to selective FGFR inhibitors, according to the detection of FGFR kinase domain mutations and/or PI3K/mTOR pathway alterations.
Rastislav Bahleda (16617234) +21 more
core +2 more sources
Diethylene Glycol-Linked Ring-Fused Bis-Azoles: Target-Oriented Synthesis, In Silico Screening, and Antitumor Activity. [PDF]
ChemMedChemA series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Al-Hussain SA +6 more
europepmc +2 more sources
FGFR-2, FGFR-2-IIIb and FGFR-2-IIIc mRNA expression in thyroid cancer progression.
, 2013 (A) Quantitative Real-Time PCR analysis of FGFR-2-IIIb mRNA expression in normal thyroid tissue, hyperplastic thyroid tissue, follicular adenoma and papillary carcinoma. Relative FGFR-2-IIIb mRNA levels are shown as fold value of the level of FGFR-2-IIIb
Giorgio Di Rocco (382578) +10 more
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Paths of FGFR-driven tumorigenesis [PDF]
Cell Cycle, 2009 Fibroblast growth factor receptors (FGFRs) comprise a subfamily of receptor tyrosine kinases (RTKs) that are master regulators of a broad spectrum of cellular and developmental processes, including apoptosis, proliferation, migration and angiogenesis. Due to their broad impact, FGFRs and other RTKs are highly regulated and normally only basally active.
Victor D, Acevedo +2 more
openaire +2 more sources
Immunohistochemical expression of FGF-2, FGFR-2 and FGFR-3 in OSCC and PMOLs.
, 2015 Immunohistochemical expression of FGF-2, FGFR-2 and FGFR-3 in OSCC and PMOLs.
Vikram Bhatia (406012) +6 more
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