Results 51 to 60 of about 32,832 (202)

Real time PCR results of FGF-2, FGFR-2 and FGFR-3 and frequency of FGF-2, FGFR-2 and FGFR-3 malignant transformation rate (A-D).

, 2015
Bar diagram showing fold change expression of FGF-2, FGFR-2 and FGFR-3 by Real Time. A, PCR in OSMF, LKP, OSCC and healthy controls. B, Frequency of FGF-2 malignant transformation rate in PMOLs.
Vikram Bhatia (406012), Seema Nayak (813016), Annu Makker (813017), Saumya Chandra (813018), Sandeep Kumar (145759), Madhu Mati Goel (473426), S. P. Agarwal (813019)   +6 more
core   +1 more source

A comprehensive overview of selective and novel fibroblast growth factor receptor inhibitors as a potential anticancer modality

Acta Pharmaceutica
The arrival of comprehensive genome sequencing has accelerated the understanding of genetically aberrant advanced cancers and target identification for possible cancer treatment.
Jain Nem Kumar, Tailang Mukul, Thangavel Neelaveni, Makeen Hafiz A., Albratty Mohammed, Najmi Asim, Alhazmi Hassan Ahmad, Zoghebi Khalid, Alagusundaram Muthumanickam, Jain Hemant Kumar, Chandrasekaran Balakumar   +10 more
doaj   +1 more source

Network Dynamics Caused by Genomic Alteration Determine the Therapeutic Response to FGFR Inhibitors for Lung Cancer

Biomolecules, 2022
Recently, FGFR inhibitors have been highlighted as promising targeted drugs due to the high prevalence of FGFR1 amplification in cancer patients. Although various potential biomarkers for FGFR inhibitors have been suggested, their functional effects have
Jonghoon Lee, Sea Rom Choi, Kwang-Hyun Cho   +2 more
doaj   +1 more source

FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation

, 2009
Critical steps in coronary vascular formation include the epithelial–mesenchyme transition (EMT) that epicardial cells undergo to become sub-epicardial; the invasion of the myocardium; and the differentiation of coronary lineages.
Pennisi, David J., Pennisi, D. J., Mikawa, Takashi, Mikawa, T   +3 more
core   +1 more source

Figure 3 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer

, 2023
FGFR kinase domain mutations detected at progression on FGFR inhibitors in urothelial cancer. A, Heat map representing individual patient data among the cohort of FGFR3-driven urothelial cancers. B–G, Molecular and radiologic findings.
Rastislav Bahleda (16617234), Giorgia Guaitoli (16827105), Francesco Facchinetti (16827090), David Combarel (16827111), Stefan Michiels (9081965), Antoine Hollebecque (15010338), Yoann Pradat (15352227), Santiago Ponce-Aix (16827114), Sergey I. Nikolaev (15061686), Luc Friboulet (15025943), Lambros Tselikas (15019536), Ludovic Bigot (16617254), Juan David Florez Arango (16827102), Hayato Mizuta (16827108), Benjamin Besse (15061674), Damien Vasseur (16827096), Cédric Pobel (16617263), Olivier Déas (16827099), Floriane Braye (16827093), Ken A. Olaussen (16827117), Yohann Loriot (15123021), Jean-Yves Scoazec (15036392)   +21 more
core   +1 more source

Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. [PDF]

PLoS ONE, 2012
Fibroblast Growth Factor receptor (FGFR) activity plays crucial roles in tumor growth and patient survival. However, FGF (Fibroblast Growth Factor) signaling as a target for cancer therapy has been under-investigated compared to other receptor tyrosine ...
Frédéric Larrieu-Lahargue, Alana L Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y Li, Andreas Bikfalvi, Patrick Auguste   +6 more
doaj   +1 more source

FGF/FGFR signaling in health and disease [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractGrowing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells.
Yangli Xie, Nan Su, Jing Yang, Qiaoyan Tan, Shuo Huang, Min Jin, Zhenhong Ni, Bin Zhang, Dali Zhang, Fengtao Luo, Hangang Chen, Xianding Sun, Jian Q. Feng, Huabing Qi, Lin Chen   +14 more
openaire   +2 more sources

Tackling FGFR Fusion-Positive Cancers with a Novel Synergistic Combination of FGFR and HDAC Inhibitors

, 2023
FGFR genomic alterations have been implicated in a number of cancers as oncogenesis driver genes. However, despite the approval of several FGFR inhibitors as targeted therapies for the treatment of cancer patients with FGFR aberrations in recent years ...
Wang, Zechen
core  

Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients

Cancer Biology & Medicine, 2016
The fibroblast growth factor receptor (FGFR) family plays important roles in regulating cell growth, proliferation, survival, differentiation and angiogenesis.
Wen-Ya Zhou, Hong Zheng, Xiao-Ling Du, Ji-Long Yang   +3 more
doaj   +1 more source

Mechanisms of FGFR-mediated carcinogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
In this review, the evidence for a role of fibroblast growth factor receptor (FGFR) mediated signalling in carcinogenesis are considered and relevant underlying mechanisms highlighted. FGF signalling mediated by FGFR follows a classic receptor tyrosine kinase signalling pathway and its deregulation at various points of its cascade could result in ...
Ahmad, Imran, Iwata, Tomoko, Leung, Hing Y.   +2 more
openaire   +2 more sources