Results 61 to 70 of about 32,832 (202)

INCB054828 inhibits FGFR-dependent signaling pathways.

, 2020
(A) KG1a or (B) RT-4 cells were treated with INCB054828 for 2 hours, lysed and subjected to immunoblotting for phospho- and total proteins in the FGFR signal transduction pathway including FGFR, ERK, FRS2, and STAT5.
Kevin Bowman (5435744), Wenqing Yao (314606), Xiaoming Wen (1302228), Mark Rupar (2537560), Patricia Feldman (7541663), Yue Zhang (30585), Timothy C. Burn (2332189), Maryanne Covington (2139592), Gregory Hollis (2245555), Krista A. Burke (8741697), Peggy Scherle (2139556), Christine Gardiner (8741703), Richard Wynn (2332183), Reid Huber (2666968), Liangxing Wu (418408), Swamy Yeleswaram (2139574), Sharon Diamond (2139568), Michael Hansbury (8741694), Holly Koblish (5435765), Ronald Klabe (2666971), Maxim Soloviev (8741700), Paul Collier (2069650), Phillip C. C. Liu (8741688), Darlise DiMatteo (8741691), Xin He (48101), Bruce Ruggeri (2080048), Alla Volgina (8741706)   +26 more
core   +1 more source

Immunohistochemical expression of FGF-2, FGFR-2 and FGFR-3 in OSCC and PMOLs.

, 2015
Immunohistochemical expression of FGF-2, FGFR-2 and FGFR-3 in OSCC and PMOLs.
Vikram Bhatia (406012), Seema Nayak (813016), Annu Makker (813017), Saumya Chandra (813018), Sandeep Kumar (145759), Madhu Mati Goel (473426), S. P. Agarwal (813019)   +6 more
core   +1 more source

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor [PDF]

Cancer Discovery, 2012
Abstract Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel and selective ...
Vito, Guagnano, Audrey, Kauffmann, Simon, Wöhrle, Christelle, Stamm, Moriko, Ito, Louise, Barys, Astrid, Pornon, Yao, Yao, Fang, Li, Yun, Zhang, Zhi, Chen, Christopher J, Wilson, Vincent, Bordas, Mickaël, Le Douget, L Alex, Gaither, Jason, Borawski, John E, Monahan, Kavitha, Venkatesan, Thomas, Brümmendorf, David M, Thomas, Carlos, Garcia-Echeverria, Francesco, Hofmann, William R, Sellers, Diana, Graus-Porta   +23 more
openaire   +2 more sources

Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma. [PDF]

PLoS ONE, 2015
There are several factors like angiogenesis, lymphangiogenesis, genetic alterations, mutational factors that are involved in malignant transformation of potentially malignant oral lesions (PMOLs) to oral squamous cell carcinoma (OSCC).
Seema Nayak, Madhu Mati Goel, Annu Makker, Vikram Bhatia, Saumya Chandra, Sandeep Kumar, S P Agarwal   +6 more
doaj   +1 more source

FGF-FGFR family pan-cancer

, 2023
Code and data for FGF-FGFR family pan-cancer ...
ss alines (16649271)
core   +1 more source

Dysregulated lipids homeostasis disrupts CHAC1-mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer

Redox Biology
Aims: This study investigates the mechanisms underlying acquired resistance to FGFR tyrosine kinase inhibitor (FGFR-TKI) in gastric cancer (GC), focusing on the interplay between ferroptosis and lipid metabolism of tumor cells.
Jingwen Chen, Yedi Huang, Daocheng Zuo, Ruimin Shan, Songmao Li, Ran Li, Dong Hua, Qiang Zhan, Xudong Song, Yun Chen, Pei Ma, Ling Ma, Guoquan Tao, Yongqian Shu   +13 more
doaj   +1 more source

FGFR- gene family alterations in low-grade neuroepithelial tumors

Acta Neuropathologica Communications, 2020
The discovery of fibroblast growth factor receptor (FGFR) gene family alterations as drivers of primary brain tumors has generated significant excitement, both as potential therapeutic targets as well as defining hallmarks of histologic entities. However,
Tejus A. Bale
doaj   +1 more source

Fibroblast Growth Factor Receptor-2 Contributes to the Basic Fibroblast Growth Factor-Induced Neuronal Differentiation in Canine Bone Marrow Stromal Cells via Phosphoinositide 3-Kinase/Akt Signaling Pathway. [PDF]

PLoS ONE, 2015
Bone marrow stromal cells (BMSCs) are considered as candidates for regenerative therapy and a useful model for studying neuronal differentiation. The role of basic fibroblast growth factor (bFGF) in neuronal differentiation has been previously studied ...
Rei Nakano, Kazuya Edamura, Tomohiro Nakayama, Takanori Narita, Ken Okabayashi, Hiroshi Sugiya   +5 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 1-4 Genetic Aberrations as Clinically Relevant Biomarkers in Squamous Cell Lung Cancer

Frontiers in Oncology, 2022
Fibroblast growth factor receptor (FGFR) inhibitors (FGFRis) are a potential therapeutic option for squamous non-small cell lung cancer (Sq-NSCLC).
Joanna Moes-Sosnowska, Joanna Chorostowska-Wynimko   +1 more
doaj   +1 more source

439 Extracellular-in-frame deletions and kinase domain duplications are novel, gain-of-function mutations in fibroblast growth factor receptor genes in cancer

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: There are gain-of-function genomic alterations in FGFR genes that guide personalized treatment in some patients with cholangiocarcinoma (10%) and bladder cancer (30%) who can benefit from targeted therapies.
Leah Stein, Julie W. Reeser, Michele R. Wing, Chunjie Li, Karthikeyan Murugesan, Dean Pavlick, Emily L. Hoskins, Raven Vella, Georgia Rigsbee, Sameek Roychowdhury   +9 more
doaj   +1 more source