Results 81 to 90 of about 35,836 (258)

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer

Nature Communications
Fibroblast growth factor receptor (FGFR) alterations are targetable in metastatic urothelial carcinoma (mUC). Identifying FGFR alterations currently requires tissue testing, which is limited by sample availability and cancer heterogeneity.
David C. Müller, Andrew J. Murtha, Jack V. W. Bacon, Maria Stephenson, Connor Wells, Carlos Vasquez-Rios, Kimia Rostin, Lisa Rebane, Elena Schönlau, Jussi Nikkola, Nimira Alimohamed, Naveen S. Basappa, Daygen Finch, Jenny J. Ko, Jean-Michel Lavoie, Lucia Nappi, Krista Noonan, Michael Ong, Guliz Ozgun, Sunil Parimi, Maryam Soleimani, Srikala S. Sridhar, Paul Toren, Eric Winquist, Cecily Q. Bernales, Melissa Koudjanian, Jaskirat Atwal, Emily Fung, Laiba Khan, Bryndan Eigl, Dalia Othman, Tarek A. Bismar, Gang Wang, Reem Merza, Andreas I. Papadakis, Alan Spatz, Christian Kollmannsberger, Corinne Maurice-Dror, Matti Annala, Kim N. Chi, Gillian Vandekerkhove, Alexander W. Wyatt, Bernhard J. Eigl   +42 more
doaj   +1 more source

ARQ 087 inhibits FGFR phosphorylation.

, 2016
COS-1 cells ectopically expressing FGFR1, FGFR2, FGFR3 or FGFR4 were treated with the indicated concentrations of ARQ 087 for 2 hours followed by stimulation with 100 pM of FGF1/2/7 for 15 minutes.
Jean-Marc Lapierre (2861762), Ronald E. Savage (813914), Yi Yu (28902), Sudharshan Eathiraj (813915), Brian Schwartz (767427), Terence G. Hall (3119784), Giovanni Abbadessa (486595), Yunxia Wang (294320)   +7 more
core   +1 more source

Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models

The Anatomical Record, EarlyView.
Abstract Sequence variations in fibroblast growth factor receptor 2 (FGFR2) are associated with craniosynostosis syndromes, disrupting craniofacial development, yet early mandibular alterations remain poorly characterized. This study examined Meckel's cartilage (MC) and mandibular morphology in mouse models of Apert (Fgfr2+/P253R) and Crouzon ...
Fred R. Foster, Alexandre Freire, Ana Cláudia Rossi, Jordan Wilson, Joan T. Richtsmeier, Kazuhiko Kawasaki, Felippe B. Prado, Susan M. Motch Perrine   +7 more
wiley   +1 more source

Altered Fibroblast Growth Factor Receptor 4 Stability Promotes Prostate Cancer Progression

Neoplasia: An International Journal for Oncology Research, 2008
Fibroblast growth factor receptor 4 (FGFR-4) is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous.
Jianghua Wang, Wendong Yu, Yi Cai, Chengxi Ren, Michael M. Ittmann   +4 more
doaj   +1 more source

FGFR families: biological functions and therapeutic interventions in tumors

MedComm, 2023
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and autophosphorylates, thereby activating several key downstream pathways that play an ...
Qing Liu, Jiyu Huang, Weiwei Yan, Zhen Liu, Shu Liu, Weiyi Fang   +5 more
doaj   +1 more source

Advances and challenges in targeting FGFR signalling in cancer

, 2016
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported ...
Irina S. Babina, Nicholas C. Turner, Turner, NC, Babina, IS   +3 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation

, 2009
Critical steps in coronary vascular formation include the epithelial–mesenchyme transition (EMT) that epicardial cells undergo to become sub-epicardial; the invasion of the myocardium; and the differentiation of coronary lineages.
Pennisi, David J., Pennisi, D. J., Mikawa, Takashi, Mikawa, T   +3 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source