Results 91 to 100 of about 35,836 (258)
Structural basis for the activation of FGFR by NCAM [PDF]
, 2008 Udgivelsesdato: October 2008The fibroblast growth factor receptor (FGFR) can be activated through direct interaction with the neural cell adhesion molecule (NCAM). The extracellular part of the FGFR consists of three immunoglobulin-like (Ig) modules, and
Vladimir Berezin +9 more
core +1 more source
Supplementary Figure 4 from c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors
, 2017 c-Myc downregulation determines the response to FGFR inhibition of FGFR constitutively activated BaF3/TEL-FGFR cells.
Min Huang (161268) +10 more
core +1 more source
Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1
, 1994 We have studied the signal transduction pathways of fibroblast growth factor receptor-4 (FGFR-4) and FGFR-1, which showed virtually identical acidic fibroblast growth factor binding profiles as well as tyrosine autophosphorylation upon activation in ...
S. Wennström +5 more
core +1 more source
Characterization of FGFR Alterations and Activation in Patients with High-Risk Non–Muscle-Invasive Bladder Cancer [PDF]
Purpose:The Genomic Analysis of High-Risk Non–Muscle-Invasive Bladder Cancer (GARNER) study investigated FGFR alteration (ALT) frequency and the clinical outcome relationship with Bacillus Calmette–Guérin (BCG) treatment in high-risk non–muscle-invasive ...
Shibata, Yoichiro +13 more
core +1 more source
Gene expression profile of FGF-2, FGFR-2 & FGFR-3 by Quantitative Real—time PCR.
, 2015 Gene expression profile of FGF-2, FGFR-2 & FGFR-3 by Quantitative Real—time PCR.
Vikram Bhatia (406012) +6 more
core +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Approximately 6%–8% of children and adolescents with rhabdomyosarcoma (RMS) have an underlying cancer predisposition disorder (CPD), which varies between embryonal and alveolar subtypes and other clinical characteristics. Identifying a CPD remains challenging, as traditional approaches rely on clinical features and family history. Additionally,
Taylor M. Luckie +12 more
wiley +1 more source
Supplementary Figure 1 from c-Myc Alteration Determines the Therapeutic Response to FGFR Inhibitors
, 2017 FGFR inhibition induces G1 phase cell cycle arrest in FGFR-addicted cancer cells.
Min Huang (161268) +10 more
core +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited.
Jorine Arnouts +14 more
wiley +1 more source
Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer
International Journal of Cancer, EarlyView.ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue +6 more
wiley +1 more source
FGFR2-fusions define a clinically actionable molecular subset of pancreatic cancer
npj Precision OncologyGenomic alterations in fibroblast growth factor receptor (FGFR) genes are present in a small number of metastatic pancreatic ductal adenocarcinomas (PDAC) and may represent an emerging subgroup of patients likely to benefit from FGFR targeted therapies ...
Leah Stein +16 more
doaj +1 more source