Results 91 to 100 of about 32,832 (202)

The FGFR Inhibitor BGJ398 Has Activity in Tumors with FGFR Alterations [PDF]

Cancer Discovery, 2017
Abstract BGJ398 has a tolerable safety profile at the determined dose and activity against several tumor types.
openaire   +1 more source

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

, 2012
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbor oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase ...
Riccardi, Riccardo
core   +2 more sources

532 Evaluating fibroblast growth factor receptor (FGFR) pathway mRNA expression and protein activation in cholangiocarcinoma tumors

Journal of Clinical and Translational Science
Objectives/Goals: Personalized cancer therapy based on genomic testing is advancing patient care. Genomic alterations in fibroblast growth factor receptor (FGFR) predict response to FGFR inhibitors; however, the role of RNA expression and protein ...
Leah Stein, Julie W. Reeser, Michele R. Wing, Eric Samorodnitsky, Anoosha Paruchuri, Amy Smith, Thuy Dao, Zachary Risch, Emanuel F. Petricoin, Sameek Roychowdhury   +9 more
doaj   +1 more source

FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin

, 2007
The role of fibroblast growth factors (FGFs) in blood vessel formation has remained unclear. We used differentiating stem-cell cultures (embryoid bodies) and teratomas to show that FGIF receptor-1 (FGFR-1) exerts a negative regulatory effect on ...
Dimberg, Anna,, Mellberg, Sofie,, Claesson-Welsh, Lena,, Magnusson, Peetra U,, Lukinius, Agneta,   +4 more
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Targeting FGFR in bladder cancer : ready for clinical practice?

, 2020
Objective: To give a brief literature overview of current knowledge regarding FGFR inhibition in bladder cancer. Background: The deeper molecular understanding of bladder urothelial carcinoma (UC) has reshaped the diagnostic and therapeutic landscape of ...
De Maeseneer, Daan, De Keukeleire, Stijn, Rottey, Sylvie, Jacobs, Celine   +3 more
core   +1 more source

Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R

Communications Chemistry
Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors. Sulfatinib is a multi-target kinase inhibitor for treating neuroendocrine tumors, selectively targeting ...
Qianmeng Lin, Shuyan Dai, Lingzhi Qu, Hang Lin, Ming Guo, Hudie Wei, Yongheng Chen, Xiaojuan Chen   +7 more
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Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors

Global Medical Genetics
The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair.
Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, Yong Song   +123 more
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High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial.

, 2016
FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical trial, we show that gastric cancers with high-level clonal FGFR2 amplification have a high ...
E. Kilgour (7782980), C. Geh (7782986), S. Chua (7662866), A. Gillbanks (7783010), J. Campbell (7758590), S. R. Johnston (7783001), K. Fenwick (7710497), A. Swain (7782998), R. Cutts (7782992), K. Sumpter (7783007), C. Rooney (7782989), M. Ajaz (7783004), D. Cunningham (2534575), G. Brown (569084), N. R. Smith (7782983), C. Peckitt (7782977), M. T. Herrera-Abreu (7782971), S. Popat (7783016), J. Ning (7782995), E. Smyth (7782965), D. Watkins (3494225), I. Chau (7783013), N. Tarazona (7782974), Anne Thomas (90885), I. S. Babina (7782968), N. C. Turner (7783019), A. Pearson (7649903)   +26 more
core  

Structural basis for the activation of FGFR by NCAM

, 2008
Udgivelsesdato: October 2008The fibroblast growth factor receptor (FGFR) can be activated through direct interaction with the neural cell adhesion molecule (NCAM). The extracellular part of the FGFR consists of three immunoglobulin-like (Ig) modules, and
Vladimir Berezin, Kochoyan, Artur, Arthur Kochoyan, Poulsen, Flemming, Bock, Elisabeth Marianne, Kiselyov, Vladislav, Flemming M. Poulsen, Elisabeth Bock, Vladislav V. Kiselyov, Berezin, Vladimir   +9 more
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Sequential Fibroblast Growth Factor Receptor Inhibition in Intrahepatic Cholangiocarcinoma: Navigating an Evolving Landscape of Resistance and Opportunity—A Case Report and Current Opinion

Oncology and Therapy
Fibroblast growth factor receptor ( FGFR ) 2 rearrangements define a distinct molecular subset of intrahepatic cholangiocarcinoma (iCCA) with therapeutic potential using FGFR inhibitors.
Hideki Sasanuma, Hironori Yamaguchi
doaj   +1 more source