Results 31 to 40 of about 32,832 (202)
, 2023 Dysregulation of Fibroblast Growth Factor Receptors (FGFRs) signaling has been associated with breast cancer, yet employing FGFR-targeted delivery systems to improve cytotoxic agents is still sparsely exploited.
Marco, Sá +12 more
core +1 more source
Fibroblast growth factor receptor fusions in cancer: opportunities and challenges
Journal of Experimental & Clinical Cancer Research, 2021 Fibroblast growth factors (FGFs) and their receptors (FGFRs) play critical roles in many biological processes and developmental functions. Chromosomal translocation of FGFRs result in the formation of chimeric FGFR fusion proteins, which often cause ...
Lingfeng Chen +6 more
doaj +1 more source
The role of Memo in premature aging and FGFR signaling [PDF]
, 2012 Memo was recently identified in a screen for proteins required for ErbB receptor induced cell migration. Encoded by a single-copy gene present in all branches of life, it is ubiquitously expressed during all stages of embryogenesis and in adult tissues ...
Hänzi, Barbara
core +1 more source
Fibroblast growth factor receptor-2 expression in thyroid tumor progression: potential diagnostic application. [PDF]
PLoS ONE, 2013 Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified.
Adriano Redler +10 more
doaj +1 more source
Oncogenic FGFR Fusions Produce Centrosome and Cilia Defects by Ectopic Signaling
Cells, 2021 A single primary cilium projects from most vertebrate cells to guide cell fate decisions. A growing list of signaling molecules is found to function through cilia and control ciliogenesis, including the fibroblast growth factor receptors (FGFR). Aberrant
Alexandru Nita +3 more
doaj +1 more source
Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer [PDF]
, 2010 Breast cancer, the main cancer in women, occurs in approximately 27% of all yearly diagnosed cancer cases. It is estimated that one out of eight women will develop breast cancer in her lifetime.
Dey, Julien Hervé
core +1 more source
Supplementary Table 2 from Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
, 2023 Systemic treatment received by patients prior to selective FGFR inhibitors, according to the detection of FGFR kinase domain mutations and/or PI3K/mTOR pathway alterations.
Rastislav Bahleda (16617234) +21 more
core +2 more sources
Heliyon, 2023 Cholangiocarcinomas and urothelial carcinomas are lethal tumors worldwide and only a minority of patients are eligible for surgery at diagnosis.
Demi Wekking +7 more
doaj +1 more source
Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer
npj Precision Oncology, 2021 Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness.
Ikuko Takeda Nakamura +13 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundThe emergence of immune checkpoint inhibitors (ICIs) has significantly improved the clinical outcomes of patients with metastatic melanoma. However, survival benefits are only observed in a subset of patients.
Wengang Zhang +12 more
doaj +1 more source