377 FGFR protein phosphorylation as a biomarker for FGFR-targeted therapy in cholangiocarcinoma [PDF]
Journal of Clinical and Translational ScienceObjectives/Goals: Cholangiocarcinoma is an aggressive cancer with a poor prognosis. Fibroblast Growth Factor Receptor 2 fusions are therapeutic targets in ~20% of cholangiocarcinoma, which restricts their benefit to only a subset of patients.
Zachary Risch +7 more
doaj +3 more sources
Efficacy and safety of first- versus second-generation fibroblast growth factor receptor (FGFR) inhibitors in advanced or metastatic urothelial carcinoma with FGFR alterations: a systematic review and meta-analysis [PDF]
Frontiers in PharmacologyIntroductionWe reviewed the clinical studies on fibroblast growth factor receptor (FGFR) inhibitors for the treatment of urothelial carcinoma to conduct the meta-analysis of clinical efficacy and safety, aiming to provide more precise treatment options ...
Zhe Wang +3 more
doaj +2 more sources
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy [PDF]
MedCommThe fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling, primarily comprising FGFs, FGFRs, and the co‐receptor Klotho, regulates key physiological processes, including embryogenesis, tissue homeostasis, metabolism, and neurodevelopment ...
Miaoyu Song +4 more
doaj +2 more sources
Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling
Cells, 2021 FGFR (fibroblast growth factor receptor) signaling controls fundamental processes in embryonic, fetal and adult human life. The magnitude, duration, and location of FGFR signaling must be strictly controlled in order to induce the correct biological ...
Ellen M Haugsten +2 more
exaly +3 more sources
Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer
Cells, 2021 Lung cancer is the most common cause of cancer-related deaths globally. Genetic alterations, such as amplifications, mutations and translocations in the fibroblast growth factor receptor (FGFR) family have been found in non-small cell lung cancer (NSCLC)
Laura Pacini +2 more
exaly +3 more sources
FGFR Fusions in the Driver's Seat [PDF]
Cancer Discovery, 2013 Abstract Summary: Through a clinical deep sequencing protocol, Wu and colleagues have identified multiple FGFR fusion proteins in diverse cancers. Pharmacologic inhibition of FGFR suppressed the growth of FGFR fusion–positive tumor models, suggesting that these FGFR fusions are oncogenic drivers and highlighting the use of streamlined ...
Sabnis, Amit J, Bivona, Trever G
openaire +6 more sources
Targeting FGFR Pathways in Gastrointestinal Cancers: New Frontiers of Treatment
Biomedicines, 2023 In carcinogenesis of the gastrointestinal (GI) tract, the deregulation of fibroblast growth factor receptor (FGFR) signaling plays a critical role.
Margherita Ratti +7 more
doaj +2 more sources
Targeting FGFR for cancer therapy
Journal of Hematology & OncologyThe FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dysregulation of this pathway is implicated in numerous human cancers, positioning FGFR as a prominent therapeutic target.
Pei Zhang +6 more
doaj +3 more sources
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Molecular CancerFibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal transduction, but can also drive tumorigenesis.
Mei Peng, Jun Deng, Xiangping Li
doaj +2 more sources
Recent Advances in Tumor Therapy Targeting FGFR
Zhongliu Fangzhi Yanjiu, 2022 Abnormal FGFR signaling has been found in a variety of cancers. The abnormal FGFR signaling is involved in several processes of tumorigenesis which include cell survival, proliferation, inflammation, migration, angiogenesis, epithelial-mesenchymal ...
ZHANG Jing +4 more
doaj +1 more source