Results 1 to 10 of about 220,683 (249)

Conceptualization of fibroblast growth factor receptor 1 targeting nanomedicines [PDF]

Exploration of Targeted Anti-tumor Therapy
Fibroblast growth factor receptor 1 (FGFR1) is crucial in the progression of various cancers, participating in the processes of cell proliferation, survival, and differentiation. FGFR1 plays a role in the resistance to immune checkpoint inhibitors (ICIs)
Yilin Ma, Mengqin Guo, Yang Liu, Zhengwei Huang   +3 more
doaj   +5 more sources

Protein kinase B inhibitors enhance the sensitivity of translocated promoter region–fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis [PDF]

Journal of International Medical Research
Objective Fibroblast growth factor receptor 1 (FGFR1) inhibitors are considered effective for treating 8p11 myeloproliferative syndrome. However, targeting FGFR1 alone may be inadequate for patients with translocated promoter region (TPR)–FGFR1 ...
Mengyao Lv, Wenbing Shangguan, Qian Zhao, Yan Li, Quan Zhao, Feng Li   +5 more
doaj   +2 more sources

Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer [PDF]

Molecular Therapy: Nucleic Acids
Impaired fibroblast growth factor receptor (FGFR) signaling is associated with many human conditions, including growth disorders, degenerative diseases, and cancer.
Vladimira Zlinska, Zuzana Feketova, Aleksandra Czyrek, Julia Chudzian, Martina Lenarcic Zivkovic, Vlad-Constantin Ursachi, Pooja Dudeja, Bohumil Fafilek, Jan Rynes, Gustavo Rico-Llanos, Adolf Koudelka, Tanaya Roy, Martyna Biadun, Vendula Raskova, Katerina Svozilova, Michaela Stroblova, Mateusz Krzyscik, Kalina Hristova, Daniel Krowarsch, Silvie Foldynova-Trantirkova, Malgorzata Zakrzewska, Lukas Trantirek, Pavel Krejci   +22 more
doaj   +2 more sources

Future perspectives: targeting fibroblast growth factor receptor 1 to enhance the efficacy of immunotherapy [PDF]

Exploration of Targeted Anti-tumor Therapy
Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in the progression of various cancers through its involvement in cell proliferation, survival, and differentiation.
Ilya Tsimafeyeu
doaj   +2 more sources

Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. [PDF]

Angew Chem Int Ed Engl, 2021
AbstractAberrant activation of FGFR signaling occurs in many cancers, and ATP‐competitive FGFR inhibitors have received regulatory approval. Despite demonstrating clinical efficacy, these inhibitors exhibit dose‐limiting toxicity, potentially due to a lack of selectivity amongst the FGFR family and are poorly tolerated.
Du G, Jiang J, Wu Q, Henning NJ, Donovan KA, Yue H, Che J, Lu W, Fischer ES, Bardeesy N, Zhang T, Gray NS.   +11 more
europepmc   +3 more sources

Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells [PDF]

Cells
The Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF ...
Barbara Hausott, Lena Pircher, Michaela Kind, Jong-Whi Park, Peter Claus, Petra Obexer, Lars Klimaschewski   +6 more
doaj   +2 more sources

Fibroblast growth factor receptor 1 amplification in laryngeal squamous cell carcinoma. [PDF]

PLoS ONE, 2018
Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes.
Jesus Monico, Brandon Miller, Luminita Rezeanu, Warren May, Donna C Sullivan   +4 more
doaj   +2 more sources

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis [PDF]

Archives of Medical Science, 2019
Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao, Jin-Hua Zhou, Jing-Jing Cai, Rui-Juan Liu   +3 more
doaj   +2 more sources

Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer [PDF]

Cancer Medicine, 2020
Background Targeting fibroblast growth factor receptor 1 (FGFR1) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification.
Omar Elakad, Anna‐Maria Lois, Katja Schmitz, Sha Yao, Sara Hugo, Laura Lukat, Marc Hinterthaner, Bernhard C. Danner, Alexander vonHammerstein‐Equord, Kirsten Reuter‐Jessen, Hans‐Ulrich Schildhaus, Philipp Ströbel, Hanibal Bohnenberger   +12 more
doaj   +2 more sources

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Drug Design, Development and Therapy, 2016
Anna Szlachcic, Malgorzata Zakrzewska, Michal Lobocki, Piotr Jakimowicz, Jacek Otlewski Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland Abstract: Fibroblast growth factor receptors (FGFRs) are ...
Szlachcic A, Zakrzewska M, Lobocki M, Jakimowicz P, Otlewski J   +4 more
doaj   +5 more sources