Conceptualization of fibroblast growth factor receptor 1 targeting nanomedicines [PDF]
Exploration of Targeted Anti-tumor TherapyFibroblast growth factor receptor 1 (FGFR1) is crucial in the progression of various cancers, participating in the processes of cell proliferation, survival, and differentiation. FGFR1 plays a role in the resistance to immune checkpoint inhibitors (ICIs)
Yilin Ma +3 more
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Protein kinase B inhibitors enhance the sensitivity of translocated promoter region–fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis [PDF]
Journal of International Medical ResearchObjective Fibroblast growth factor receptor 1 (FGFR1) inhibitors are considered effective for treating 8p11 myeloproliferative syndrome. However, targeting FGFR1 alone may be inadequate for patients with translocated promoter region (TPR)–FGFR1 ...
Mengyao Lv +5 more
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Specific inhibition of fibroblast growth factor receptor 1 signaling by a DNA aptamer [PDF]
Molecular Therapy: Nucleic AcidsImpaired fibroblast growth factor receptor (FGFR) signaling is associated with many human conditions, including growth disorders, degenerative diseases, and cancer.
Vladimira Zlinska +22 more
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Future perspectives: targeting fibroblast growth factor receptor 1 to enhance the efficacy of immunotherapy [PDF]
Exploration of Targeted Anti-tumor TherapyFibroblast growth factor receptor 1 (FGFR1) plays a critical role in the progression of various cancers through its involvement in cell proliferation, survival, and differentiation.
Ilya Tsimafeyeu
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Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells [PDF]
CellsThe Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF ...
Barbara Hausott +6 more
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Fibroblast growth factor receptor 1 amplification in laryngeal squamous cell carcinoma. [PDF]
PLoS ONE, 2018 Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes.
Jesus Monico +4 more
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The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis [PDF]
Archives of Medical Science, 2019 Introduction Identifying target oncogenic alterations in lung cancer represents a major development in disease management. We examined the association of fibroblast growth factor receptor 1 (FGFR1) gene amplification with pathological characteristics and
Jian-Long Miao +3 more
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Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer [PDF]
Cancer Medicine, 2020 Background Targeting fibroblast growth factor receptor 1 (FGFR1) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification.
Omar Elakad +12 more
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Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins [PDF]
Cell Communication and Signaling, 2019 Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma membrane. FGFRs signaling needs to be precisely adjusted as aberrant FGFRs function is associated with development of human cancers or ...
Marika Kucińska +7 more
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Quantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia [PDF]
PeerJ, 2017 Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS).
Lisha Choubey +2 more
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