Results 11 to 20 of about 1,166 (115)

Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone [PDF]

Molecular Endocrinology, 2003
Thyroid hormone (T3) and the T3 receptor (TR) alpha gene are essential for bone development whereas adult hyperthyroidism increases the risk of osteoporotic fracture. We isolated fibroblast growth factor receptor-1 (FGFR1) as a T3-target gene in osteoblasts by subtraction hybridization. FGFR1 mRNA was induced 2- to 3-fold in osteoblasts treated with T3
Stevens, D.A., Harvey, C.B., Scott, A.J., O'Shea, P.J., Barnard, J.C., Williams, A.J., Brady, G., Samarut, Jacques, Chassande, Olivier, Williams, G.R.   +9 more
openaire   +3 more sources

Fibroblast growth factor receptor 1 extracellular vesicle as novel therapy for osteoarthritis

Гений oртопедии, 2021
Introduction Osteoarthritis (OA) is a joint condition that causes significant impairment of the chondrocyte. The gradual degradation of the cartilage lining of one or more freely moving joints, as well as persistent inflammation, are the causes of ...
Bryan Gervais de Liyis, John Nolan, Made Agus Maharjana   +2 more
doaj   +1 more source

Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling

Tumor Biology, 2017
Ovarian cancer is the most lethal gynecologic malignancy, due to its high propensity for metastasis. Cancer-associated fibroblasts, as the dominant component of tumor microenvironment, are crucial for tumor progression. However, the mechanisms underlying
Yuanzhen Sun, Xiaoli Fan, Qing Zhang, Xiaoyu Shi, Guangwei Xu, Cuimin Zou   +5 more
doaj   +1 more source

Morphofunctional Characterization of Different Tissue Factors in Congenital Diaphragmatic Hernia Affected Tissue

Diagnostics, 2021
Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development. Although the morbidity and mortality rate is rather significant, the pathogenesis of CDH has been studied insignificantly due to the decreased ...
Ricards Kaulins, Laura Ramona Rozite, Mara Pilmane, Aigars Petersons   +3 more
doaj   +1 more source

A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis [PDF]

Microbial Pathogenesis, 2018
Summary Neisseria meningitidis remains an important cause of human disease. It is highly adapted to the human host – its only known reservoir. Adaptations to the host environment include many specific interactions with human molecules including iron-binding proteins, components of the innate and ...
Sheyda Azimi, Lee M. Wheldon, Neil J. Oldfield, Dlawer A.A. Ala’Aldeen, Karl G. Wooldridge   +4 more
openaire   +2 more sources

Durable response from fibroblast growth factor receptor inhibition in intrahepatic cholangiocarcinoma terminated by metachronous acute myeloid leukemia: a case report

Journal of Medical Case Reports, 2023
Introduction Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a ...
Andreas Edwin Juarso, Stefanie Entz, Florian Weissinger   +2 more
doaj   +1 more source

Exploring the Gamut of Receptor Tyrosine Kinases for Their Promise in the Management of Non-Alcoholic Fatty Liver Disease

Biomedicines, 2021
Recently, non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant health concern affecting approximately a quarter of the world’s population.
Sayali Bhave, Han Kiat Ho
doaj   +1 more source

Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor [PDF]

Journal of Cell Science, 2011
Fibroblast growth factor receptor 1 (FGFR1) is an oncoprotein with known involvement in mammary tumorigenesis. To understand how FGFR1 signaling promotes mammary tumorigenesis, an inducible FGFR1 (iFGFR1) system was created previously. Previous studies have demonstrated that upon iFGFR1 activation in vivo, the epidermal growth factor (EGF) ligands ...
Lindsey K, Bade, Jodi E, Goldberg, Hazel A, Dehut, Majken K, Hall, Kathryn L, Schwertfeger   +4 more
openaire   +2 more sources

Fibroblast Growth Factor Receptor 1 Gene Amplification in Nonsmall Cell Lung Cancer

Chinese Medical Journal, 2016
Objective: To review the prevalence and prognostic significance of fibroblast growth factor receptor 1 (FGFR1) amplification and to establish an association between FGFR1 amplification and the clinical characteristics of nonsmall cell lung cancer (NSCLC).
Jian-Long Miao, Rui-Juan Liu, Jin-Hua Zhou, Shu-Hua Meng   +3 more
doaj   +1 more source

AZD9291 Resistance Reversal Activity of a pH‐Sensitive Nanocarrier Dual‐Loaded with Chloroquine and FGFR1 Inhibitor in NSCLC

Advanced Science, 2021
AZD9291 can effectively prolong survival of non‐small cell lung cancer (NSCLC) patients. Unfortunately, the mechanism of its acquired drug resistance is largely unknown.
Yu Gu, Songtao Lai, Yang Dong, Hao Fu, Liwei Song, Tianxiang Chen, Yourong Duan, Zhen Zhang   +7 more
doaj   +1 more source