Drug Design, Development and Therapy, 2016 Anna Szlachcic, Malgorzata Zakrzewska, Michal Lobocki, Piotr Jakimowicz, Jacek Otlewski Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland Abstract: Fibroblast growth factor receptors (FGFRs) are ...
Szlachcic A +4 more
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FGFR1 (Fibroblast Growth Factor Receptor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on FGFR1 (fibroblast growth factor receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Huret, JL
core +10 more sources
Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. [PDF]
PLoS ONE, 2012 Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Ana Tomasovic +2 more
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Autocrine Fibroblast Growth Factor Receptor 1 Signaling Activates Lactate Dehydrogenase A-Aerobic Glycolysis for Advanced Human Prostate Tumor Growth [PDF]
Prostate CancerConclusion: Our data indicate autocrine FGF/FGFR1 signaling regulates aerobic glycolysis in PCa DU145 cells via LDHA, suggesting the potential of targeting FGFs/FGFRs-LDHA for the management of advanced PCa.
Xiaoming Xu +7 more
doaj +2 more sources
Calcitriol downregulates fibroblast growth factor receptor 1 through histone deacetylase activation in HL-1 atrial myocytes [PDF]
Journal of Biomedical Science, 2018 Background Fibroblast growth factor (FGF)-2 plays a crucial role in the pathophysiology of cardiovascular diseases (CVDs). FGF-2 was reported to induce cardiac hypertrophy through activation of FGF receptor 1 (FGFR1).
Ting-Wei Lee +4 more
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Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes [PDF]
Arthritis Research & TherapyDongyao Yan +6 more
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Biochemistry and Biophysics Reports, 2021 Fibroblast growth factor (FGF) 23 produced by the bone is the principal hormone to regulate serum phosphate level. Serum FGF23 needs to be tightly regulated to maintain serum phosphate in a narrow range.
Yuichi Takashi +8 more
doaj +1 more source
Comprehending fibroblast growth factor receptor like 1: Oncogene or tumor suppressor?
Cancer Treatment and Research Communications, 2021 Fibroblast Growth Factor Receptor Like 1 (FGFRL1) signaling has crucial role in a multitude of processes during genetic diseases, embryonic development and various types of cancer.
Aprajita, Rinu Sharma
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Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. [PDF]
Angew Chem Int Ed Engl, 2021 AbstractAberrant activation of FGFR signaling occurs in many cancers, and ATP‐competitive FGFR inhibitors have received regulatory approval. Despite demonstrating clinical efficacy, these inhibitors exhibit dose‐limiting toxicity, potentially due to a lack of selectivity amongst the FGFR family and are poorly tolerated.
Du G +11 more
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Fibroblast Growth Factors 1 and 2 and Fibroblast Growth Factor Receptor 1 Are Elevated in Thyroid Hyperplasia [PDF]
The Journal of Clinical Endocrinology & Metabolism, 1998 We have previously reported increased expression of fibroblast growth factor (FGF-1 and FGF-2) in benign and malignant human thyroid neoplasia. To determine the role of these factors in thyroid hyperplasia we have examined their expression in multinodular goiter and compared findings with those in normal thyroid tissue. Because the effects of FGF-1 and
S D, Thompson +5 more
openaire +2 more sources