Results 1 to 10 of about 1,147 (109)

FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer [PDF]

Cell Adhesion and Migration, 2020
Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC.
Ying Yang, Shun Lu
exaly   +4 more sources

FGFR1 is a potential therapeutic target in neuroblastoma [PDF]

Cancer Cell International, 2022
Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived pediatric tumor arising in ...
Flora Cimmino, Annalaura Montella, Matilde Tirelli, Marianna Avitabile, Vito Alessandro Lasorsa, Feliciano Visconte, Sueva Cantalupo, Teresa Maiorino, Biagio De Angelis, Martina Morini, Aurora Castellano, Franco Locatelli, Mario Capasso, Achille Iolascon   +13 more
doaj   +5 more sources

Effects of FGFR1 Gene Polymorphisms on the Risk of Breast Cancer and FGFR1 Protein Expression [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Fibroblast growth factor receptor 1 (FGFR1) is widely considered to play an important role in mammary carcinogenesis. Some common variants in FGFR1 might be associated with its expression, and further affect breast cancer risk.
Junqiang Wu, Yuhang Wang, Jing Liu, Qianlin Chen, Da Pang, Yongdong Jiang   +5 more
doaj   +3 more sources

18F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imaging

Frontiers in Oncology, 2023
IntroductionThe fibroblast growth factor receptor (FGFR) family is highly expressed in a variety of tumor types and represents a new target for cancer therapy.
Yang Chen, Yang Chen, Jingya Han, Yan Zhao, Xinming Zhao, Xinming Zhao, Mengmeng Zhao, Jingmian Zhang, Jianfang Wang   +8 more
doaj   +3 more sources

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening.
Junwei Wang, Lina Gao
exaly   +2 more sources

ZNF198-FGFR1 Transforms Ba/F3 Cells to Growth Factor Independence and Results in High Level Tyrosine Phosphorylation of STATS 1 and 5

Neoplasia, 1999
The ZNF198-FGFR1 fusion gene arises as a result of the t(8;13)(p11;g12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line
Nicholas Cross, Janet Shipley, Damian Smedley   +2 more
exaly   +3 more sources

GZD824 overcomes FGFR1‐V561F/M mutant resistance in vitro and in vivo

Cancer Medicine, 2021
Abnormallyactivated FGFR1 has been validated as a therapeutic target for differentcancers. Although a variety of FGFR inhibitors have shown benefit in manyclinical patients with FGFR1 aberration, FGFR1 mutant resistance such as V561Mmutation, has been ...
Jing Guo, Ke Ding, Ke Ding
exaly   +2 more sources

Identification of a peptide antagonist of the FGF1–FGFR1 signaling axis by phage display selection

FEBS Open Bio, 2019
Overexpression of fibroblast growth factor receptor 1 (FGFR1) is a common aberration in lung and breast cancers and has necessitated the design of drugs targeting FGFR1‐dependent downstream signaling and FGFR1 ligand binding.
Jacek Otlewski, Aleksandra Czyrek, Anna Szlachcic   +2 more
exaly   +2 more sources

Pharmacological and Biological Targeting of FGFR1 in Cancer

Current Issues in Molecular Biology
FGFR1 is a key member of the fibroblast growth factor receptor family, mediating critical signaling pathways such as RAS-MAPK and PI3K-AKT. which are integral to regulating essential cellular processes, including proliferation, differentiation, and survival.
Lei Dong, Mei Tian, Wanting Xu
exaly   +4 more sources

FGF8–FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner

Disease Models & Mechanisms, 2022
Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing hormone-expressing neurons (GnRH neurons).
Venkatram Yellapragada, Nazli Eskici, Yafei Wang, Shrinidhi Madhusudan, Kirsi Vaaralahti, Timo Tuuri, Taneli Raivio   +6 more
doaj   +1 more source