Results 1 to 10 of about 29,080 (157)

FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer [PDF]

Cell Adhesion and Migration, 2020
Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC.
Ying Yang, Shun Lu
exaly   +4 more sources

Pharmacological and Biological Targeting of FGFR1 in Cancer

Current Issues in Molecular Biology
FGFR1 is a key member of the fibroblast growth factor receptor family, mediating critical signaling pathways such as RAS-MAPK and PI3K-AKT. which are integral to regulating essential cellular processes, including proliferation, differentiation, and ...
Wenyu Wang, Wanting Xu, Yutong Zhou
exaly   +5 more sources

FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactylation and metabolic reprogramming [PDF]

Cell Death Discovery
Ovarian cancer (OC) is an aggressive gynecological malignancy with poor prognosis, largely due to late-stage diagnosis and high metastatic potential. However, the functional role and regulatory mechanisms of fibroblast growth factor receptor 1 (FGFR1) in
Fan Jiang, Huaju Huang, Zhe Dong, Lu Zhang, Shiti Zhang, Mengnan Long, Xue Fan, Nan Li, Hao Ai   +8 more
doaj   +2 more sources

P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells

Cells, 2019
In female mammals, the abnormal apoptosis of ovarian granulosa cells (GCs) impairs follicular development and causes reproductive dysfunction. Many studies have indicated that the FGFR1 gene of the PI3K signaling pathway and the p65 subunit of the ...
Xiaolong Yuan, Yuyi Zhong, Yingting He   +2 more
exaly   +3 more sources

ZNF198-FGFR1 Transforms Ba/F3 Cells to Growth Factor Independence and Results in High Level Tyrosine Phosphorylation of STATS 1 and 5

Neoplasia, 1999
The ZNF198-FGFR1 fusion gene arises as a result of the t(8;13)(p11;g12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line
Damian Smedley, Colin Cooper, Janet Shipley   +2 more
exaly   +3 more sources

GZD824 overcomes FGFR1‐V561F/M mutant resistance in vitro and in vivo

Cancer Medicine, 2021
Abnormallyactivated FGFR1 has been validated as a therapeutic target for differentcancers. Although a variety of FGFR inhibitors have shown benefit in manyclinical patients with FGFR1 aberration, FGFR1 mutant resistance such as V561Mmutation, has been ...
Jing Guo, Zhengchao Tu, Xiaomei Ren
exaly   +2 more sources

Identification of a peptide antagonist of the FGF1–FGFR1 signaling axis by phage display selection

FEBS Open Bio, 2019
Overexpression of fibroblast growth factor receptor 1 (FGFR1) is a common aberration in lung and breast cancers and has necessitated the design of drugs targeting FGFR1‐dependent downstream signaling and FGFR1 ligand binding.
Anna Szlachcic, Aleksandra Czyrek, Jacek Otlewski   +2 more
exaly   +2 more sources

FGF8–FGFR1 signaling regulates human GnRH neuron differentiation in a time- and dose-dependent manner

Disease Models & Mechanisms, 2022
Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing hormone-expressing neurons (GnRH neurons).
Venkatram Yellapragada, Nazli Eskici, Yafei Wang, Shrinidhi Madhusudan, Kirsi Vaaralahti, Timo Tuuri, Taneli Raivio   +6 more
doaj   +1 more source

Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma

OncoImmunology, 2022
Fibroblast growth factor receptor 1 (FGFR1) is overexpressed in multiple types of solid tumors, including head and neck squamous cell carcinoma (HNSCC).
Michihisa Kono, Hiroki Komatsuda, Hidekiyo Yamaki, Takumi Kumai, Ryusuke Hayashi, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Hiroya Kobayashi, Yasuaki Harabuchi   +15 more
doaj   +1 more source

Diagnosis and Treatment of Clonal Myeloproliferative Neoplasms with Eosinophilia

Клиническая онкогематология, 2020
Aim. Based on our own materials to characterize the clinical manifestations of hypereosinophilic states distinguishing between reactive eosinophilia (RE), clonal myeloproliferative neoplasms with eosinophilia (MPN-eo), and myeloproliferative variant of ...
Irina Semenovna Nemchenko, N. N. Tsyba, A. G. Turkina, E. Yu. Chelysheva, O. A. Shukhov, A. M. Kovrigina, T. N. Obukhova   +6 more
doaj   +1 more source