18F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imaging [PDF]
Frontiers in Oncology, 2023 IntroductionThe fibroblast growth factor receptor (FGFR) family is highly expressed in a variety of tumor types and represents a new target for cancer therapy.
Yang Chen +8 more
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Pharmacological and Biological Targeting of FGFR1 in Cancer
Current Issues in Molecular BiologyFGFR1 is a key member of the fibroblast growth factor receptor family, mediating critical signaling pathways such as RAS-MAPK and PI3K-AKT. which are integral to regulating essential cellular processes, including proliferation, differentiation, and ...
Lei Dong, Qin Xia
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A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition [PDF]
Leukemia & Lymphoma, 2023 Myeloid/lymphoid neoplasms with FGFR1 rearrangement (FGFR1r) are rare entities, characterized by the aberrant expression of the tyrosine kinase involving the fibroblast growth factor receptor 1 (FGFR1) in a pluripotent, both myeloid and lymphoid, progenitor cell1.
Carlos Jiménez-Vicente +14 more
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Cell Communication and Signaling, 2023 Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk +8 more
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FGFR1 is a potential therapeutic target in neuroblastoma [PDF]
Cancer Cell International, 2022 Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived pediatric tumor arising in ...
Flora Cimmino +13 more
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P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells
Cells, 2019 In female mammals, the abnormal apoptosis of ovarian granulosa cells (GCs) impairs follicular development and causes reproductive dysfunction. Many studies have indicated that the FGFR1 gene of the PI3K signaling pathway and the p65 subunit of the ...
Zhe Zhang, Zhe Zhang, Xiaolong Yuan
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Effects of FGFR1 Gene Polymorphisms on the Risk of Breast Cancer and FGFR1 Protein Expression [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibroblast growth factor receptor 1 (FGFR1) is widely considered to play an important role in mammary carcinogenesis. Some common variants in FGFR1 might be associated with its expression, and further affect breast cancer risk.
Junqiang Wu +5 more
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Neoplasia, 1999 The ZNF198-FGFR1 fusion gene arises as a result of the t(8;13)(p11;g12) in the 8p11 myeloproliferative syndrome. To determine the transforming properties of this chimeric protein we transfected ZNF198-FGFR1 into the interleukin (IL)-3 dependent cell line
Nicholas Cross +2 more
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FGFR1 expression defines clinically distinct subtypes in pancreatic cancer
Journal of Translational Medicine, 2018 Background The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expression in pancreatic cancer ...
Farhan Haq +6 more
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FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells [PDF]
Journal of Experimental & Clinical Cancer Research, 2017 Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC).
Hong Yuan +5 more
openaire +4 more sources