Results 41 to 50 of about 29,080 (157)

Activating FGFR1 Mutations in Sporadic Pheochromocytomas [PDF]

World Journal of Surgery, 2017
AbstractIntroductionPheochromocytomas are neuroendocrine tumors of the adrenal glands. Up to 40% of the cases are caused by germline mutations in one of at least 15 susceptibility genes, making them the human neoplasms with the highest degree of heritability.
Welander J, Łysiak M, Brauckhoff M, Brunaud L, Söderkvist P, Gimm O   +5 more
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Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer

The Journal of Clinical Investigation, 2023
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detected by
Florian Malchers, Lucia Nogova, Martijn H.A. van Attekum, Lukas Maas, Johannes Brägelmann, Christoph Bartenhagen, Luc Girard, Graziella Bosco, Ilona Dahmen, Sebastian Michels, Clare E. Weeden, Andreas H. Scheel, Lydia Meder, Kristina Golfmann, Philipp Schuldt, Janna Siemanowski, Jan Rehker, Sabine Merkelbach-Bruse, Roopika Menon, Oliver Gautschi, Johannes M. Heuckmann, Elisabeth Brambilla, Marie-Liesse Asselin-Labat, Thorsten Persigehl, John D. Minna, Henning Walczak, Roland T. Ullrich, Matthias Fischer, Hans Christian Reinhardt, Jürgen Wolf, Reinhard Büttner, Martin Peifer, Julie George, Roman K. Thomas   +33 more
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Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon. [PDF]

PLoS ONE, 2016
FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected FGFR1 amplified patients by FISH. Lung cancer cell lines were profiled for sensitivity to AZD4547, a potent, selective inhibitor of FGFRs 1-3. Sensitivity to FGFR
Claire Rooney, Catherine Geh, Victoria Williams, Johannes M Heuckmann, Roopika Menon, Petra Schneider, Katherine Al-Kadhimi, Michael Dymond, Neil R Smith, Dawn Baker, Tim French, Paul D Smith, Elizabeth A Harrington, J Carl Barrett, Elaine Kilgour   +14 more
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FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2017
Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC).
Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia, Shun Lu   +5 more
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Identification of mechanism of the oncogenic role of FGFR1 in papillary thyroid carcinoma

European Journal of Histochemistry
Papillary thyroid carcinoma (PTC) is the most prevalent malignancy of the thyroid. Fibroblast growth factor receptor 1 (FGFR1) is highly expressed in PTC and works as an oncogenic protein in this disease.
Xiong Bing Li, Jia Li Li, Chao Wang, Yong Zhang, Jing Li   +4 more
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Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

Molecular Cancer, 2008
Background The t(6;8) translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein.
Tassin Anne-Marie, Chevrier Véronique, Lelièvre Hélène, Birnbaum Daniel   +3 more
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FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas

Frontiers in Oncology, 2019
The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, highlighting the importance of identifying novel chemotherapeutic targets.
Naomi Egbivwie, Julia V. Cockle, Matthew Humphries, Azzam Ismail, Filomena Esteves, Claire Taylor, Katherine Karakoula, Ruth Morton, Tracy Warr, Susan C. Short, Anke Brüning-Richardson   +10 more
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NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS). [PDF]

PLoS ONE, 2013
Nerve growth factor (NGF) is the founding member of the polypeptide neurotrophin family responsible for neuronal differentiation. To determine whether the effects of NGF rely upon novel Integrative Nuclear FGF Receptor-1 (FGFR1) Signaling (INFS) we ...
Yu-Wei Lee, Ewa K Stachowiak, Barbara Birkaya, Christopher Terranova, Mariolina Capacchietti, Peter Claus, John M Aletta, Michal K Stachowiak   +7 more
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The prevalence of Fibroblast Growth Factor Receptor 1 Gene (FGFR1) amplification in Non-Small Cell Lung Cancer (NSCLC) by Real-time PCR [PDF]

Caspian Journal of Internal Medicine
Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients.
Sanaz Homayounfar, Hossein Ayatollahi, Gordon Ferns, Reza Hemmatan Attarbashi, Masoumeh Gharib, Maryam Sheikhi, Zahra Khoshnegah, Payam Siyadat, Amirhossein Jafarian   +8 more
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Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer

Cancer Medicine, 2020
Background Targeting fibroblast growth factor receptor 1 (FGFR1) is a potential treatment for squamous cell lung cancer (SQCLC). So far, treatment decision in clinical studies is based on gene amplification.
Omar Elakad, Anna‐Maria Lois, Katja Schmitz, Sha Yao, Sara Hugo, Laura Lukat, Marc Hinterthaner, Bernhard C. Danner, Alexander vonHammerstein‐Equord, Kirsten Reuter‐Jessen, Hans‐Ulrich Schildhaus, Philipp Ströbel, Hanibal Bohnenberger   +12 more
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