Results 51 to 60 of about 6,610 (202)

β-Thalassemia major complicated by 8p11 myeloproliferative syndrome: a case report and literature review

Guangxi Yike Daxue xuebao
β-Thalassemia is an inherited hemolytic anemia caused by defects in the β-globin gene. β-Thalassemia major results from homozygous or compound heterozygous β0 or β+ mutations.
Jianming Gong, Yunyan He, Wenguang Jia, Jianming Luo   +3 more
doaj   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

npj Precision Oncology, 2022
Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous-cell lung cancer (SQCLC).
Omar Elakad, Björn Häupl, Vera Labitzky, Sha Yao, Stefan Küffer, Alexander von Hammerstein-Equord, Bernhard C. Danner, Manfred Jücker, Henning Urlaub, Tobias Lange, Philipp Ströbel, Thomas Oellerich, Hanibal Bohnenberger   +12 more
doaj   +1 more source

Characterization of Oncogenic Fusion BCR-FGFR1 [PDF]

, 2019
Fibroblast Growth Factor Receptors (FGFRs) are part of the Receptor Tyrosine Kinase (RTK) family and are essential in the activation of various downstream signaling pathways, which are necessary for cell differentiation and proliferation.
Peiris, Malalage Nicole
core   +1 more source

NGF accelerates nuclear trafficking of FGFR1 by reducing FGFR1 nuclear export.

, 2013
(A) FGFR1-EGFP was transfected into PC12 cells. Twenty-four hours after transfection, cultures were treated with 50 ng/ml NGF and LMB (100 ng/ml in 0.1% v/v ethanol) or ethanol alone (0.1% v/v ethanol) for an additional 48 h and during subsequent imaging.
Mariolina Capacchietti (432340), Peter Claus (183761), Michal K. Stachowiak (426955), Yu-Wei Lee (432337), John M. Aletta (432341), Barbara Birkaya (75355), Christopher Terranova (432339), Ewa K. Stachowiak (432338)   +7 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

The sum is greater than the FGFR1 partner [PDF]

Cancer Cell, 2004
Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific translocations may be associated ...
Braun, Benjamin S, Shannon, Kevin
openaire   +2 more sources

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer

, 2010
Lung cancer remains one of the leading causes of cancer-related death in developed countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions respond to treatment by epidermal growth factor receptor (EGFR) and anaplastic lymphoma ...
Moch, H, M. Hallek, Stefanie Heynck, Thunnissen, E., E. Stoelben, C. Brambilla, Ullrich, R.M., Smit, Egbert, Smit, E., Heynck, Stefanie, P. Wagener, Wagener, Patrick, S. Maier, Conron, M., Schöttle, Jakob, R. K. Thomas, Heuckmann, J., D. Seidel, Ansén, Sascha, I. Dabow, J. Schöttle, E. Smit, B. Solomon, S. Ansén, Iver Petersen, K. Ernestus, Hallek, M., Fischer, Florian, Baumann, M., Ullrich, R., Florian Fischer, Matthew Conron, Z. Wainer, Ines Dabow, Heuckmann, Johannes M., R. T. Ullrich, J. Sänger, P. Nürnberg, F. Gabler, Roopika Menon, S. Heynck, Thunnissen, Erik, Soltermann, Alex, Querings, S., Smit, E.F., Thomas, Roman K., Moch, Holger, Petersen, I., Maier, S., Wolf, J., Timens, Wim, Sos, Martin L., Klebl, Bert, Heynck, S., Timens, W., Martin L. Sos, Fischer, F., Sänger, J., Thomas, R.K, Cappuzzo, Federico, Silvia Querings, Groen, Harry, Balke-Want, Hyatt, Querings, Silvia, Daniel Rauh, Ligorio, Claudia, Seidel, D, Erich Stoelben, D. Rauh, Weiss, J, Menon, Roopika, Baessmann, I., Frauke Leenders, Ludwig, Corinna, Engel-Riedel, W., W. Pao, Karen Ernestus, Lorimier, P., Sos, M L, E. Brambilla, Jonathan Weiss, J. Clement, Stoelben, Erich, Heidemann, Danielle, Wagener, P., S. Querings, Hannie Sietsma, Damiani, S., Rauh, Daniel, Franziska Gabler, Thomas Zander, Christian Brambilla, S. Perner, R. Buettner, Koker, Mirjam, Heideman, D., Weiss, Jonathan, G. Wright, Harry Groen, Johannes M. Heuckmann, Engel-Riedel, Walburga, Menon, R., Baumann, Matthias, Altmueller, Janine, Hyatt Balke-Want, Saenger, Joerg, Klebl, B., Moch, H., Walburga Engel Riedel, Alex Soltermann, Rameen Beroukhim, J. Weiss, P. Russell, Groen, H., Clement, Joachim, M. Conron, Mirjam Koker, Weiss, J., Solomon, B., S. Sollberg, Ligorio, C., J. M. Heuckmann, Damiani, Stefania, Brambilla, C., Heukamp, L., Walburga Engel-Riedel, Jürgen Wolf, Heuckmann, J.M., Zoe Wainer, Perner, S., et al, Wainer, Zoe, H. Sietsma, Wolf, Juergen, Pao, W., B. Klebl, Pao, William, Gavin Wright, P. Lorimier, Altmüller, Janine, Lukas C. Heukamp, J. Wolf, Brustugun, Odd Terje, Janine Altmüller, Stefania Damiani, Dabow, Ines, Schoettle, Jakob, Thomas, R.K., Daniëlle Heideman, A. Soltermann, Heideman, Danielle, M. L. Sos, Bert Klebl, Ludwig, C., Erik Thunnissen, Peifer, M., Jakob Schöttle, Seidel, D., W. Timens, Brambilla, E., Sebastian Maier, Soltermann, A., Ullrich, Roland T., Ernestus, Karen, Brustugun, O., Brambilla, Elisabeth, Elisabeth Brambilla, Wright, Gavin, Zander, Thomas, D. Heideman, Matthias Baumann, Lorimier, Philippe, Ben Solomon, Clement, J., Brustugun, O.T., Leenders, Frauke, Ansén, S., Sänger, Jörg, Ullrich, R.T., Corinna Ludwig, Gabler, F., Zander, T., Ingelore Baessmann, Beroukhim, R., Buettner, Reinhard, F. Fischer, Heideman, D.A.M., Sven Perner, Peter Nürnberg, R. Beroukhim, Odd Terje Brustugun, Philippe Lorimier, F. Leenders, Sos, M.L., Sietsma, Hannie, Wim Timens, Federico Cappuzzo, Roland T. Ullrich, Egbert Smit, H. Moch, M. Peifer, Sascha Ansén, Cappuzzo, F., Steinar Sollberg, Sollberg, S., Joachim Clement, Maier, Sebastian, Roman K. Thomas, Sos, M., R. Menon, Nürnberg, P., H. Balke Want, Jörg Sänger, Stoelben, E., Nuernberg, Peter, Solomon, Ben, Sollberg, Steinar, M. Baumann, Dabow, I., Beroukhim, Rameen, Claudia Ligorio, Prudence Russell, Baessmann, Ingelore, Leenders, F., Thunnissen, F.B.J.M., Cappuzzo, Frederico, Danila Seidel, William Pao, Wright, G., Patrick Wagener, I. Baessmann, Seidel, Danila, Brambilla, Christian, Russell, P., Thomas, R., Rauh, D., L. C. Heukamp, Koker, M., Conron, Matthew, Balke-Want, H., O. Terje Brustugun, H. Groen, T. Zander, Nürnberg, Peter, Buettner, R., Schöttle, J., Wainer, Z., F. Cappuzzo, J. Altmüller, Timens, Wim; id_orcid, Wolf, Jürgen, Hallek, Michael, Perner, Sven, E. Thunnissen, Ernestus, K., Gabler, Franziska, Groen, Harry; id_orcid, Soltermann, A, Martin Peifer, Peifer, Martin, Altmüller, J., Petersen, Iver, Michael Hallek, Sietsma, H., Heukamp, L.C., Heukamp, Lukas C., Russell, Prudence, M. Koker, Heidemann, D., Holger Moch, Reinhard Buettner   +270 more
core   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Targeted Inhibition of Fibroblast Growth Factor Receptor 1-GLI Through AZD4547 and GANT61 Modulates Breast Cancer Progression

Frontiers in Cell and Developmental Biology, 2021
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients.
Syeda Kiran Riaz, Syeda Kiran Riaz, Syeda Kiran Riaz, Walizeb Khan, Fen Wang, Tanwir Khaliq, Amber Malik, Eisha Tir Razia, Jahangir Sarwar Khan, Shafiul Haque, Shafiul Haque, Anwar M. Hashem, Anwar M. Hashem, Shadi S. Alkhayyat, Najiah Esam Azhar, Steve Harakeh, Steve Harakeh, Mohammad Javed Ansari, Farhan Haq, Muhammad Faraz Arshad Malik   +19 more
doaj   +1 more source