Results 51 to 60 of about 7,115 (188)

Molecular Expression of FGF23 Signaling Components (FGFR1 and α-Klotho) and Their Biochemical Correlation in Early Kidney Impairment [PDF]

BIO Web of Conferences
Background: Chronic kidney disease and mineral and bone disorder (CKD-MBD) is associated with dysfunction of the FGF23-FGFR1-a-Klotho signaling pathway involved in phosphate regulation and renal function.
Mohamed Y. H., Ahmed M. N.
doaj   +1 more source

Reciprocal regulatory mechanism between miR-214-3p and FGFR1 in FGFR1-amplified lung cancer [PDF]

Oncogenesis, 2019
Abstract MicroRNA (miRNA) and fibroblast growth factor receptor 1 (FGFR1) dysregulation are considered to play an important role in tumor proliferation, invasion, and metastasis. However, the regulatory mechanism between miRNAs and FGFR1 in lung cancer remains unclear and extremely critical. miR-214-3p was sharply
Ying Yang, Ziming Li, Hong Yuan, Wenxiang Ji, Kaixuan Wang, Tingting Lu, Yongfeng Yu, Qingyu Zeng, Fan Li, Weiliang Xia, Shun Lu   +10 more
openaire   +2 more sources

Single‐Nucleus Atlas of Spinal Sarcopenia Patients Reveals Disruption of Quiescent and Regenerative Satellite Cell Niches in Fatty‐Infiltrated Muscle

Advanced Science, EarlyView.
Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu, Renxian Wang, Dingding Wang, Quanzhong Ren, Ling Wang, Fangfang Duan, Guihe Yang, Ruixuan Yu, Yi Wang, Yingyu Zhang, Zetong Zang, Chuqi Li, Weijia Liu, Wenshuang Zhang, Yi Yuan, Zitong Cheng, Xiaoguang Cheng, Junbo Liang, Yajun Liu   +18 more
wiley   +1 more source

Untersuchung des unterschiedlichen Therapieansprechens FGFR1-amplifizierter Lungenkrebszellen [PDF]

Lungenkrebs ist unter den verschiedenen Krebsarten immer noch weltweit die Haupttodesursache. Da bereits für Adenokarzinome molekular-gerichtete Therapien bestehen, gilt es auch im Bereich von Plattenepithel- und kleinzelligen Karzinomen wirksamere ...
Schaefer, Mariella, Uhmann, Anja, Georg-August-Universität Göttingen, Ströbel, Philipp, Schön, Margarete   +4 more
core   +1 more source

β-Thalassemia major complicated by 8p11 myeloproliferative syndrome: a case report and literature review

Guangxi Yike Daxue xuebao
β-Thalassemia is an inherited hemolytic anemia caused by defects in the β-globin gene. β-Thalassemia major results from homozygous or compound heterozygous β0 or β+ mutations.
Jianming Gong, Yunyan He, Wenguang Jia, Jianming Luo   +3 more
doaj   +1 more source

Differential expression of FGFRs signaling pathway components in bladder cancer: A step toward personalized medicine

Balkan Journal of Medical Genetics, 2017
Variations Improper activation and inappropriate expression of fibroblast growth factor receptors (FGFRs) in cancer suggests that they can act as therapeutic targets.
Ousati Ashtiani Z, Tavakkoly-Bazzaz J, Salami SA, Pourmand MR, Mansouri F, Mashahdi R, Pourmand G   +6 more
doaj   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Targeted Inhibition of Fibroblast Growth Factor Receptor 1-GLI Through AZD4547 and GANT61 Modulates Breast Cancer Progression

Frontiers in Cell and Developmental Biology, 2021
The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients.
Syeda Kiran Riaz, Syeda Kiran Riaz, Syeda Kiran Riaz, Walizeb Khan, Fen Wang, Tanwir Khaliq, Amber Malik, Eisha Tir Razia, Jahangir Sarwar Khan, Shafiul Haque, Shafiul Haque, Anwar M. Hashem, Anwar M. Hashem, Shadi S. Alkhayyat, Najiah Esam Azhar, Steve Harakeh, Steve Harakeh, Mohammad Javed Ansari, Farhan Haq, Muhammad Faraz Arshad Malik   +19 more
doaj   +1 more source

The sum is greater than the FGFR1 partner [PDF]

Cancer Cell, 2004
Cancer-associated chromosomal translocations create chimeric oncoproteins that contribute to aberrant growth by dominant or dominant negative mechanisms. Interestingly, genes such as MLL, RARA, and EWS are fused to multiple partners. This molecular promiscuity can provide important functional information, as specific translocations may be associated ...
Braun, Benjamin S, Shannon, Kevin
openaire   +2 more sources