Results 31 to 40 of about 7,115 (188)

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations [PDF]

, 2004
8p11 myeloproliferative syndrome (EMS) is a hematopoietic stem cell disorder characterized by myeloid hyperplasia and non-Hodgkin's lymphoma with chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor ...
Krause, Daniela S., Cross, Nicholas CP, Asiedu, Frances, Neumann, Carola A, Dimitri, Christopher A, Dimitri, Christopher A., Cross, Nicholas C.P., Van Etten, Richard A., Neumann, Carola A., Krause, Daniela S, Van Etten, Richard A, Roumiantsev, Sergei   +11 more
core   +1 more source

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening.
Jian Liu, Yu Wen, Lina Gao, Liang Gao, Fengjun He, Jingxian Zhou, Junwei Wang, Rupeng Dai, Xiaojing Chen, Di Kang, Lihong Hu   +10 more
doaj   +1 more source

Quantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia [PDF]

PeerJ, 2017
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS).
Lisha Choubey, Jantzen C. Collette, Karen Müller Smith   +2 more
doaj   +2 more sources

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology, 2020
Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl   +2 more
doaj   +1 more source

Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway

Cancer Cell International, 2022
Background Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially diagnosed as myelodysplastic ...
Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li, Jinsong Yan   +10 more
doaj   +1 more source

Dmp1-Cre-mediated conditional deletion of Fgfr1 from the floxed Fgfr1 allele (Fgfr1^flox) in different tissues.

, 2014
(A) Schematic illustration of wild-type (Fgfr1+), floxed Fgfr1 allele before (Fgfr1flox) and after deletion (Fgfr1Δflox) of the lox P cassette containing Exon 8–14 via Cre-mediated recombination.
Yingjuan Liang (608326), Leigh Darryl Quarles (306499), Zhousheng Xiao (306496), Li Cao (106383), Jinsong Huang (308466), Xiaobin Han (608327)   +5 more
core   +1 more source

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion [PDF]

, 2023
Glioblastoma is the most lethal brain cancer in adults. These incurable tumors are characterized by profound heterogeneity, therapy resistance, and diffuse infiltration.
Nawal Alshahrany, Dorit Siebzehnrubl, Florian A. Siebzehnrubl, Jimenez-Pascual, Ana, Siebzehnrubl, Dorit, Ayesha Begum, Alshahrany, Nawal, Ana Jimenez-Pascual, Siebzehnrubl, Florian A., Begum, Ayesha   +9 more
core   +1 more source

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

Asian Journal of Andrology
Fibroblast growth factor receptor 1 (FGFR1) mutations are associated with congenital hypogonadotropic hypogonadism (CHH) through inheritance or spontaneous occurrence.
Yu-Fan Yang, Hai-Lu Ma, Xi Wang, Min Nie, Jiang-Feng Mao, Xue-Yan Wu   +5 more
doaj   +1 more source

Characterization of Oncogenic Fusion BCR-FGFR1 [PDF]

, 2019
Fibroblast Growth Factor Receptors (FGFRs) are part of the Receptor Tyrosine Kinase (RTK) family and are essential in the activation of various downstream signaling pathways, which are necessary for cell differentiation and proliferation.
Peiris, Malalage Nicole
core   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source