Results 31 to 40 of about 6,610 (202)

Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. [PDF]

PLoS ONE, 2014
Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and locomotor hyperactivity in mice with a conditional Fgfr1 deletion generated ...
Karen Müller Smith, Maria Elisabetta Maragnoli, Pooja M Phull, Kathy May Tran, Lisha Choubey, Flora M Vaccarino   +5 more
doaj   +1 more source

A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication. [PDF]

PLoS ONE, 2015
Influenza A virus causes annual epidemics and occasional pandemics in humans. Here, we investigated four members of the fibroblast growth factor receptor (FGFR) family; FGFR1 to 4, and examined their expression patterns in human lung epithelial cells ...
Xin Liu, Chengcai Lai, Keyu Wang, Li Xing, Penghui Yang, Qing Duan, Xiliang Wang   +6 more
doaj   +1 more source

Differential expression of FGFRs signaling pathway components in bladder cancer: A step toward personalized medicine

Balkan Journal of Medical Genetics, 2017
Variations Improper activation and inappropriate expression of fibroblast growth factor receptors (FGFRs) in cancer suggests that they can act as therapeutic targets.
Ousati Ashtiani Z, Tavakkoly-Bazzaz J, Salami SA, Pourmand MR, Mansouri F, Mashahdi R, Pourmand G   +6 more
doaj   +1 more source

Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway

Cancer Cell International, 2022
Background Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially diagnosed as myelodysplastic ...
Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li, Jinsong Yan   +10 more
doaj   +1 more source

HPK1 and FGFR1 datasets

, 2023
IC50 and Ki dataset for HPK1 and ...
Han Li (12662224)
core   +1 more source

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

Asian Journal of Andrology
Fibroblast growth factor receptor 1 (FGFR1) mutations are associated with congenital hypogonadotropic hypogonadism (CHH) through inheritance or spontaneous occurrence.
Yu-Fan Yang, Hai-Lu Ma, Xi Wang, Min Nie, Jiang-Feng Mao, Xue-Yan Wu   +5 more
doaj   +1 more source

Quantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia [PDF]

PeerJ, 2017
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS).
Lisha Choubey, Jantzen C. Collette, Karen Müller Smith   +2 more
doaj   +2 more sources

Prognostic role of FGFR1 amplification in early-stage non-small cell lung cancer. [PDF]

, 2014
Background:Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment.
Lardinois, D, Cihoric, Nikola, Zlobec, Inti, M Gugger, D Lardinois, S Savic, Bubendorf, Lukas, M Bichsel-Naef, I Zlobec, Schmid, Ralph, Schneider, Sabine, Gugger, M, R A Schmid, I Ackermann, C Tapia, N Cihoric, Ackermann, I, L Bubendorf, Savic, Mirjana, Bichsel-Naef, Mirjam, Tapia, Coya, S Schneider   +21 more
core   +2 more sources

Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer. [PDF]

, 2021
KRAS oncoprotein is commonly mutated in human cancer, but effective therapies specifically targeting KRAS-driven tumors remain elusive. Here, we show that combined treatment with fibroblast growth factor receptor 1 (FGFR1) and polo-like kinase 1 (PLK1 ...
Thomas M Marti, Deng, Haibin, Haitang Yang, Tschan, Mario, Hegedüs, Balazs, Maria Saliakoura, Wang, Wenxiang, Schmid, Ralph A, Mario Tschan, Liang, Shun-Qing, Liang Zhao, Wenxiang Wang, Vassella, Erik, Ralph A Schmid, Georgia Konstantinidou, Saliakoura, Maria, Peng, Ren-Wang, Marti, Thomas M, Gregor J Kocher, Gao, Yanyun, Kocher, Gregor J, Balazs Hegedüs, Xu, Duo, Ren‐Wang Peng, Yanyun Gao, Eric Vassella, Duo Xu, Haibin Deng, Shun‐Qing Liang, Zhao, Liang, Yang, Haitang, Zhang Yang, Yang, Zhang, Konstantinidou, Georgia   +33 more
core   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source