Results 11 to 20 of about 29,080 (157)

FGFR1 is a potential therapeutic target in neuroblastoma [PDF]

Cancer Cell International, 2022
Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived pediatric tumor arising in ...
Flora Cimmino, Annalaura Montella, Matilde Tirelli, Marianna Avitabile, Vito Alessandro Lasorsa, Feliciano Visconte, Sueva Cantalupo, Teresa Maiorino, Biagio De Angelis, Martina Morini, Aurora Castellano, Franco Locatelli, Mario Capasso, Achille Iolascon   +13 more
doaj   +5 more sources

Effects of FGFR1 Gene Polymorphisms on the Risk of Breast Cancer and FGFR1 Protein Expression [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Fibroblast growth factor receptor 1 (FGFR1) is widely considered to play an important role in mammary carcinogenesis. Some common variants in FGFR1 might be associated with its expression, and further affect breast cancer risk.
Junqiang Wu, Yuhang Wang, Jing Liu, Qianlin Chen, Da Pang, Yongdong Jiang   +5 more
doaj   +3 more sources

18F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imaging

Frontiers in Oncology, 2023
IntroductionThe fibroblast growth factor receptor (FGFR) family is highly expressed in a variety of tumor types and represents a new target for cancer therapy.
Yang Chen, Yang Chen, Jingya Han, Yan Zhao, Xinming Zhao, Xinming Zhao, Mengmeng Zhao, Jingmian Zhang, Jianfang Wang   +8 more
doaj   +3 more sources

SHANK2-FGFR1: A Novel FGFR1 Rearrangement in a Patient with Intestinal Adenocarcinoma

Journal of the College of Physicians and Surgeons Pakistan, 2021
Null.
Hongguang, Sheng, Yugang, Jiang, Ling, Li   +2 more
openaire   +3 more sources

FGFR1 and the Bloodline of the Vasculature [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Since the recognition of basicfibroblast growth factor (bFGF, FGF-2) and acidic FGF (aFGF, FGF-1) as proliferation and maintenance factors for endothelial cells in culture,1,2 much interest has arisen regarding their role as potential angiogenic factors in tumors and tissue healing in vivo.
van Hinsbergh, V.W.M., Rabelink, T.J.
openaire   +2 more sources

The FGFR1 N546K mutation confers resistance to pemigatinib in MLN-ZMYM2::FGFR1. [PDF]

Leukemia
Shoumariyeh K, Haug S, Schwaab J, Pfeil JK, Stappenbeck J, Schmitt-Graeff A, Naumann N, Waltemode G, Zeiser R, Miething C, Hofmann WK, Meggendorfer M, Diederichs S, Duyster J, Reiter A.   +14 more
europepmc   +2 more sources

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

Cell Communication and Signaling, 2023
Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk, Natalia Porębska, Dominika Żukowska, Aleksandra Chorążewska, Aleksandra Gędaj, Agata Malinowska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński   +8 more
doaj   +1 more source

FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1

Breast Cancer Research, 2021
Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution among luminal A or B HRPBC,
Silvana Mouron, Luis Manso, Eduardo Caleiras, Jose L. Rodriguez-Peralto, Oscar M. Rueda, Carlos Caldas, Ramon Colomer, Miguel Quintela-Fandino, Maria J. Bueno   +8 more
doaj   +1 more source

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma. [PDF]

PLoS ONE, 2015
Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to multi-kinase inhibitors targeting FGFR1. Esophageal cancer is an aggressive disease, for which novel targeted therapies are highly warranted.This study ...
Katharina von Loga, Jule Kohlhaussen, Lia Burkhardt, Ronald Simon, Stefan Steurer, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Till Krech   +8 more
doaj   +1 more source

FGFR1 Is Associated With Tamoxifen Resistance and Poor Prognosis of ER-Positive Breast Cancers by Suppressing ER Protein Expression

Technology in Cancer Research & Treatment, 2021
Fibroblast growth factor receptor 1 (FGFR1) is widely recognized as a key player in mammary carcinogenesis and associated with the prognosis and therapeutic response of breast cancers.
Qing Lv MD, PhD, Shiming Guan MD, Mingjie Zhu MD, Hu Huang MD, Junqiang Wu MD, PhD, Xiaofeng Dai PhD   +5 more
doaj   +1 more source