Results 11 to 20 of about 6,610 (202)

A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition [PDF]

Leukemia & Lymphoma, 2023
Myeloid/lymphoid neoplasms with FGFR1 rearrangement (FGFR1r) are rare entities, characterized by the aberrant expression of the tyrosine kinase involving the fibroblast growth factor receptor 1 (FGFR1) in a pluripotent, both myeloid and lymphoid, progenitor cell1.
Carlos Jiménez-Vicente, Marta Garrote, Mónica López-Guerra, Eva Villamón, Francesca Guijarro, Amanda Isabel Perez-Valencia, Alexandra Martinez-Roca, Olga Balaguer, Alberto Álvarez-Larrán, Juan Carlos Hernández-Boluda, Montserrat Rovira, Dolors Colomer, Marina Diaz-Beyá, Maria Rozman, Jordi Esteve   +14 more
openaire   +4 more sources

Mechanisms of resistance to FGFR1 inhibitors in FGFR1-driven leukemias and lymphomas: implications for optimized treatment

Cancer Drug Resistance, 2021
Myeloid and lymphoid neoplasms with eosinophilia and FGFR1 rearrangements (MLN-eo FGFR1) disease is derived from a pluripotent hematopoietic stem cell and has a complex presentation with a myeloproliferative disorder with or without eosinophilia and frequently presents with mixed lineage T- or B-lymphomas.
Cowell, John K., Hu, Tianxiang
openaire   +4 more sources

FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells [PDF]

Journal of Experimental & Clinical Cancer Research, 2017
Autophagy is a conserved catabolic process to degrade cellular organelles. The role of autophagy in cancer development is complex. Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC).
Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia, Shun Lu   +5 more
openaire   +4 more sources

FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

Journal of Translational Medicine, 2018
Background The clinical significance of fibroblast growth factor receptor 1 (FGFR1) protein expression in pancreatic cancer is largely unknown. In this study, we aimed investigate the clinical significance of FGFR1 expression in pancreatic cancer ...
Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong, Sung-Min Ahn   +6 more
doaj   +2 more sources

SHANK2-FGFR1: A Novel FGFR1 Rearrangement in a Patient with Intestinal Adenocarcinoma

Journal of the College of Physicians and Surgeons Pakistan, 2021
Null.
Hongguang, Sheng, Yugang, Jiang, Ling, Li   +2 more
openaire   +3 more sources

FGFR1 and the Bloodline of the Vasculature [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Since the recognition of basicfibroblast growth factor (bFGF, FGF-2) and acidic FGF (aFGF, FGF-1) as proliferation and maintenance factors for endothelial cells in culture,1,2 much interest has arisen regarding their role as potential angiogenic factors in tumors and tissue healing in vivo.
van Hinsbergh, V.W.M., Rabelink, T.J.
openaire   +2 more sources

Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma

OncoImmunology, 2022
Fibroblast growth factor receptor 1 (FGFR1) is overexpressed in multiple types of solid tumors, including head and neck squamous cell carcinoma (HNSCC).
Michihisa Kono, Hiroki Komatsuda, Hidekiyo Yamaki, Takumi Kumai, Ryusuke Hayashi, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Hiroya Kobayashi, Yasuaki Harabuchi   +15 more
doaj   +1 more source

N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope

Cell Communication and Signaling, 2023
Fibroblast growth factor receptor 1 (FGFR1) is a heavily N-glycosylated cell surface receptor tyrosine kinase that transmits signals across the plasma membrane, in response to fibroblast growth factors (FGFs).
Paulina Gregorczyk, Natalia Porębska, Dominika Żukowska, Aleksandra Chorążewska, Aleksandra Gędaj, Agata Malinowska, Jacek Otlewski, Małgorzata Zakrzewska, Łukasz Opaliński   +8 more
doaj   +1 more source

Diagnosis and Treatment of Clonal Myeloproliferative Neoplasms with Eosinophilia

Клиническая онкогематология, 2020
Aim. Based on our own materials to characterize the clinical manifestations of hypereosinophilic states distinguishing between reactive eosinophilia (RE), clonal myeloproliferative neoplasms with eosinophilia (MPN-eo), and myeloproliferative variant of ...
Irina Semenovna Nemchenko, N. N. Tsyba, A. G. Turkina, E. Yu. Chelysheva, O. A. Shukhov, A. M. Kovrigina, T. N. Obukhova   +6 more
doaj   +1 more source

P65 Targets FGFR1 to Regulate the Survival of Ovarian Granulosa Cells

Cells, 2019
In female mammals, the abnormal apoptosis of ovarian granulosa cells (GCs) impairs follicular development and causes reproductive dysfunction. Many studies have indicated that the FGFR1 gene of the PI3K signaling pathway and the p65 subunit of the ...
Xiaolong Yuan, Zhonghui Li, Yaru Kong, Yuyi Zhong, Yingting He, Ailing Zhang, Xiaofeng Zhou, Yao Jiang, Zhe Zhang, Hao Zhang, Jiaqi Li   +10 more
doaj   +1 more source