Results 11 to 20 of about 7,115 (188)
Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer [PDF]
npj Precision Oncology, 2022 Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous-cell lung cancer (SQCLC).
Omar Elakad +12 more
doaj +2 more sources
GZD824 Overcomes FGFR1-V561F/M Mutant Resistance in Vitro and in Vivo
Cancer Medicine, 2021 Abnormallyactivated FGFR1 has been validated as a therapeutic target for differentcancers. Although a variety of FGFR inhibitors have shown benefit in manyclinical patients with FGFR1 aberration, FGFR1 mutant resistance such as V561Mmutation, has been ...
Jing Guo, Ke Ding, Ke Ding
exaly +2 more sources
Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. [PDF]
PLoS ONE, 2014 Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and locomotor hyperactivity in mice with a conditional Fgfr1 deletion generated ...
Karen Müller Smith +5 more
doaj +2 more sources
Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome
Haematologica, 2013 The 8p11 myeloproliferative syndrome is a rare, aggressive myeloproliferative neoplasm characterized by constitutively active FGFR1 fusion proteins that arise from specific chromosomal translocations and which drive aberrant proliferation. Although FGFR1
Andrew Chase +3 more
doaj +2 more sources
Disease Models & Mechanisms, 2022 Fibroblast growth factor 8 (FGF8), acting through the fibroblast growth factor receptor 1 (FGFR1), has an important role in the development of gonadotropin-releasing hormone-expressing neurons (GnRH neurons).
Venkatram Yellapragada +6 more
doaj +1 more source
FGFR1 and the Bloodline of the Vasculature [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Since the recognition of basicfibroblast growth factor (bFGF, FGF-2) and acidic FGF (aFGF, FGF-1) as proliferation and maintenance factors for endothelial cells in culture,1,2 much interest has arisen regarding their role as potential angiogenic factors in tumors and tissue healing in vivo.
van Hinsbergh, V.W.M., Rabelink, T.J.
openaire +2 more sources
OncoImmunology, 2022 Fibroblast growth factor receptor 1 (FGFR1) is overexpressed in multiple types of solid tumors, including head and neck squamous cell carcinoma (HNSCC).
Michihisa Kono +15 more
doaj +1 more source
FGFR1 regulates proliferation and metastasis by targeting CCND1 in FGFR1 amplified lung cancer [PDF]
Cell Adhesion & Migration, 2020 Aims: The analysis of the online databases revealed that CCND1 expression is correlated with poor prognosis in LSCC. We aimed to explore the function of CCND1 in tumor progression in LSCC.Main methods: The expression of mRNA was measured using qRT-PCR. Protein expression was assessed by Western blot.
Ying Yang +3 more
openaire +3 more sources
Diagnosis and Treatment of Clonal Myeloproliferative Neoplasms with Eosinophilia
Клиническая онкогематология, 2020 Aim. Based on our own materials to characterize the clinical manifestations of hypereosinophilic states distinguishing between reactive eosinophilia (RE), clonal myeloproliferative neoplasms with eosinophilia (MPN-eo), and myeloproliferative variant of ...
Irina Semenovna Nemchenko +6 more
doaj +1 more source
Breast Cancer Research, 2021 Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution among luminal A or B HRPBC,
Silvana Mouron +8 more
doaj +1 more source