Results 21 to 30 of about 6,610 (202)
Breast Cancer Research, 2021 Background FGFR1 amplification, but not overexpression, has been related to adverse prognosis in hormone-positive breast cancer (HRPBC). Whether FGFR1 overexpression and amplification are correlated, what is their distribution among luminal A or B HRPBC,
Silvana Mouron +8 more
doaj +1 more source
The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking [PDF]
, 2009 Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive.
Vladimir Berezin +16 more
core +1 more source
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S +17 more
core +1 more source
FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma. [PDF]
PLoS ONE, 2015 Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to multi-kinase inhibitors targeting FGFR1. Esophageal cancer is an aggressive disease, for which novel targeted therapies are highly warranted.This study ...
Katharina von Loga +8 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2021 Fibroblast growth factor receptor 1 (FGFR1) is widely recognized as a key player in mammary carcinogenesis and associated with the prognosis and therapeutic response of breast cancers.
Qing Lv MD, PhD +5 more
doaj +1 more source
FGFR1 expression levels predict BGJ398 Sensitivity of FGFR1-dependent head and neck Squamous cell cancers [PDF]
, 2015 Purpose: FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials.
Sharma, Rakesh +23 more
core +1 more source
TARGETING FGFR1 IN METASTATIC BREAST CANCER
, 2022 Metastasis remains the major cause of breast cancer (BC)-related death as developing an effective therapeutic strategy for the treatment of metastatic breast cancer (MBC) is a major clinical challenge.
Hang Lin (11257131)
core +3 more sources
Inducible dimerization of FGFR1 [PDF]
The Journal of Cell Biology, 2002 To develop an inducible and progressive model of mammary gland tumorigenesis, transgenic mice were generated with a mouse mammary tumor virus–long terminal repeat–driven, conditional, fibroblast growth factor (FGF)–independent FGF receptor (FGFR)1 (iFGFR1) that can be induced to dimerize with the drug AP20187.
Welm, Bryan E. +5 more
openaire +2 more sources
Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1 [PDF]
, 2013 Fibroblast growth factor (FGF) receptor-like protein 1 (FGFRL1) is a recently discovered member of the FGF receptor (FGFR) family. Similar to the classical FGFRs, it contains three extracellular immunoglobulin-like domains and interacts with FGF ligands.
Amann, Ruth, Trueb, Beat
core +2 more sources
Molecular & Cellular Oncology, 2020 Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual +2 more
doaj +1 more source