Results 21 to 30 of about 7,115 (188)

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma. [PDF]

PLoS ONE, 2015
Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to multi-kinase inhibitors targeting FGFR1. Esophageal cancer is an aggressive disease, for which novel targeted therapies are highly warranted.This study ...
Katharina von Loga, Jule Kohlhaussen, Lia Burkhardt, Ronald Simon, Stefan Steurer, Susanne Burdak-Rothkamm, Frank Jacobsen, Guido Sauter, Till Krech   +8 more
doaj   +1 more source

Neuronal FGFR1 transactivation by inducing FGFR1/5-HT1A heteroreceptor complexes formation

, 2011
There are no clear data on the molecular mechanism by which the hippocampal 5-HT transmission contributes to the neuroprotective and antidepressant effects of 5-HT uptake blockers. Previously, we revealed that a 5-HT1A agonist may induce phosphorylation of FGFR1 and ERK1/2 in rat hippocampus independent of FGF-2, suggesting transactivation of FGFR1 ...
FRINCHI, Monica, Borroto Escuela, DO, Romero Fernandez, W, DI LIBERTO, Valentina, MUDO', Giuseppa, Agnati, LF, BELLUARDO, Natale, Fuxe, K.   +7 more
openaire   +2 more sources

FGFR1 Is Associated With Tamoxifen Resistance and Poor Prognosis of ER-Positive Breast Cancers by Suppressing ER Protein Expression

Technology in Cancer Research & Treatment, 2021
Fibroblast growth factor receptor 1 (FGFR1) is widely recognized as a key player in mammary carcinogenesis and associated with the prognosis and therapeutic response of breast cancers.
Qing Lv MD, PhD, Shiming Guan MD, Mingjie Zhu MD, Hu Huang MD, Junqiang Wu MD, PhD, Xiaofeng Dai PhD   +5 more
doaj   +1 more source

The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking [PDF]

, 2009
Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive.
Vladimir Berezin, Gerhard Christofori, Christofori, Gerhard, Francavilla, Chiara; id_orcid, Paola Cattaneo, Cattaneo, Paola, Ugo Cavallaro, Cavallaro, Ugo, de Marco, Ario, Francavilla, Chiara, Ami, Diletta, Berezin, Vladimir, Ario de Marco, Chiara Francavilla, Bock, Elisabeth, Elisabeth Bock, Diletta Ami, Ami Diletta, Christofori Gerhard, De Marco A., Cattaneo Paola, Berezin Vladimir, Cavallaro Ugo, Ami D., De Marco Ario, Christofori G., Bock E., Francavilla C., Cattaneo P., Cavallaro U., Bock Elisabeth, Francavilla Chiara, Berezin V.   +32 more
core   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription Factor FOXQ1 to Promote Breast Cancer Cell Growth [PDF]

, 2023
FGFR1 is a receptor tyrosine kinase deregulated in certain breast cancers (BCs) with a poor prognosis. Although FGFR1-activated phosphorylation cascades have been mapped, the key genes regulated by FGFR1 in BC are largely unclear.
Li, Xuesen, Xu, Jianming, Lin, Fengkang, Duangmano, Suwit, He, Tao, Pornprasert, Sakorn, Li, Dabing, Yang, Mao, Ran, Bing, Yang, Wenli, Luo, Bo, Chaiwongsa, Rujirek, Lin, Yan, Anuchapreeda, Songyot, Peng, Lijia, Zhang, Zhuoran, Khamphikham, Pinyaphat, Wu, Ting, Rujirek Chaiwongsa, Sakorn Pornprasert, Dabing Li, Xuesen Li, Bing Ran, Wenli Yang, Fengkang Lin, Tao He, Songyot Anuchapreeda, Ting Wu, Suwit Duangmano, Jianming Xu, Mao Yang, Pinyaphat Khamphikham, Zhuoran Zhang, Lijia Peng, Bo Luo, Yan Lin   +35 more
core   +1 more source

Mechanisms of resistance to FGFR1 inhibitors in FGFR1-driven leukemias and lymphomas: implications for optimized treatment

Cancer Drug Resistance, 2021
Myeloid and lymphoid neoplasms with eosinophilia and FGFR1 rearrangements (MLN-eo FGFR1) disease is derived from a pluripotent hematopoietic stem cell and has a complex presentation with a myeloproliferative disorder with or without eosinophilia and frequently presents with mixed lineage T- or B-lymphomas.
Cowell, John K., Hu, Tianxiang
openaire   +3 more sources

Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1 [PDF]

, 2013
Fibroblast growth factor (FGF) receptor-like protein 1 (FGFRL1) is a recently discovered member of the FGF receptor (FGFR) family. Similar to the classical FGFRs, it contains three extracellular immunoglobulin-like domains and interacts with FGF ligands.
Amann, Ruth, Trueb, Beat, Trueb B, Amann R   +3 more
core   +2 more sources

HPK1 and FGFR1 datasets

, 2023
IC50 and Ki dataset for HPK1 and ...
Han Li (12662224)
core   +1 more source

A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication. [PDF]

PLoS ONE, 2015
Influenza A virus causes annual epidemics and occasional pandemics in humans. Here, we investigated four members of the fibroblast growth factor receptor (FGFR) family; FGFR1 to 4, and examined their expression patterns in human lung epithelial cells ...
Xin Liu, Chengcai Lai, Keyu Wang, Li Xing, Penghui Yang, Qing Duan, Xiliang Wang   +6 more
doaj   +1 more source