Results 21 to 30 of about 29,080 (157)

Inducible dimerization of FGFR1 [PDF]

The Journal of Cell Biology, 2002
To develop an inducible and progressive model of mammary gland tumorigenesis, transgenic mice were generated with a mouse mammary tumor virus–long terminal repeat–driven, conditional, fibroblast growth factor (FGF)–independent FGF receptor (FGFR)1 (iFGFR1) that can be induced to dimerize with the drug AP20187.
Bryan E. Welm, Kevin W. Freeman, Mercy Chen, Alejandro Contreras, David M. Spencer, Jeffrey M. Rosen   +5 more
openaire   +1 more source

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening.
Jian Liu, Yu Wen, Lina Gao, Liang Gao, Fengjun He, Jingxian Zhou, Junwei Wang, Rupeng Dai, Xiaojing Chen, Di Kang, Lihong Hu   +10 more
doaj   +1 more source

Mechanisms of resistance to FGFR1 inhibitors in FGFR1-driven leukemias and lymphomas: implications for optimized treatment

Cancer Drug Resistance, 2021
Myeloid and lymphoid neoplasms with eosinophilia and FGFR1 rearrangements (MLN-eo FGFR1) disease is derived from a pluripotent hematopoietic stem cell and has a complex presentation with a myeloproliferative disorder with or without eosinophilia and frequently presents with mixed lineage T- or B-lymphomas.
Cowell, John K., Hu, Tianxiang
openaire   +3 more sources

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology, 2020
Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl   +2 more
doaj   +1 more source

A novel ETV6::FGFR1 fusion gene in a myeloid/lymphoid neoplasm with FGFR1 rearrangement sensitive to specific FGFR1-2-3 inhibition

Leukemia & Lymphoma, 2023
Myeloid/lymphoid neoplasms with FGFR1 rearrangement (FGFR1r) are rare entities, characterized by the aberrant expression of the tyrosine kinase involving the fibroblast growth factor receptor 1 (FGFR1) in a pluripotent, both myeloid and lymphoid, progenitor cell1.
Carlos Jiménez-Vicente, Marta Garrote, Mónica López-Guerra, Eva Villamón, Francesca Guijarro, Amanda Isabel Perez-Valencia, Alexandra Martinez-Roca, Olga Balaguer, Alberto Álvarez-Larrán, Juan Carlos Hernández-Boluda, Montserrat Rovira, Dolors Colomer, Marina Diaz-Beyá, Maria Rozman, Jordi Esteve   +14 more
openaire   +3 more sources

Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. [PDF]

PLoS ONE, 2014
Fibroblast growth factors (Fgfs) and their receptors (Fgfr) are expressed in the developing and adult CNS. Previous studies demonstrated a decrease in cortical interneurons and locomotor hyperactivity in mice with a conditional Fgfr1 deletion generated ...
Karen Müller Smith, Maria Elisabetta Maragnoli, Pooja M Phull, Kathy May Tran, Lisha Choubey, Flora M Vaccarino   +5 more
doaj   +1 more source

A Functional Role of Fibroblast Growth Factor Receptor 1 (FGFR1) in the Suppression of Influenza A Virus Replication. [PDF]

PLoS ONE, 2015
Influenza A virus causes annual epidemics and occasional pandemics in humans. Here, we investigated four members of the fibroblast growth factor receptor (FGFR) family; FGFR1 to 4, and examined their expression patterns in human lung epithelial cells ...
Xin Liu, Chengcai Lai, Keyu Wang, Li Xing, Penghui Yang, Qing Duan, Xiliang Wang   +6 more
doaj   +1 more source

Quantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia [PDF]

PeerJ, 2017
Background Fibroblast growth factors (FGFs) and their receptors (FGFRs) have numerous functions in the developing and adult central nervous system (CNS).
Lisha Choubey, Jantzen C. Collette, Karen Müller Smith   +2 more
doaj   +2 more sources

Differential expression of FGFRs signaling pathway components in bladder cancer: A step toward personalized medicine

Balkan Journal of Medical Genetics, 2017
Variations Improper activation and inappropriate expression of fibroblast growth factor receptors (FGFRs) in cancer suggests that they can act as therapeutic targets.
Ousati Ashtiani Z, Tavakkoly-Bazzaz J, Salami SA, Pourmand MR, Mansouri F, Mashahdi R, Pourmand G   +6 more
doaj   +1 more source

Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway

Cancer Cell International, 2022
Background Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially diagnosed as myelodysplastic ...
Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li, Jinsong Yan   +10 more
doaj   +1 more source