Results 71 to 80 of about 6,610 (202)

Myeloproliferative disorder FOP-FGFR1 fusion kinase recruits phosphoinositide-3 kinase and phospholipase Cγ at the centrosome

Molecular Cancer, 2008
Background The t(6;8) translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein.
Tassin Anne-Marie, Chevrier Véronique, Lelièvre Hélène, Birnbaum Daniel   +3 more
doaj   +1 more source

Characterization of FGFR1 Locus in sqNSCLC Reveals a Broad and Heterogeneous Amplicon. [PDF]

PLoS ONE, 2016
FGFR1 amplification occurs in ~20% of sqNSCLC and trials with FGFR inhibitors have selected FGFR1 amplified patients by FISH. Lung cancer cell lines were profiled for sensitivity to AZD4547, a potent, selective inhibitor of FGFRs 1-3. Sensitivity to FGFR
Claire Rooney, Catherine Geh, Victoria Williams, Johannes M Heuckmann, Roopika Menon, Petra Schneider, Katherine Al-Kadhimi, Michael Dymond, Neil R Smith, Dawn Baker, Tim French, Paul D Smith, Elizabeth A Harrington, J Carl Barrett, Elaine Kilgour   +14 more
doaj   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

FGFR1 Expression and Role in Migration in Low and High Grade Pediatric Gliomas

Frontiers in Oncology, 2019
The heterogeneous and invasive nature of pediatric gliomas poses significant treatment challenges, highlighting the importance of identifying novel chemotherapeutic targets.
Naomi Egbivwie, Julia V. Cockle, Matthew Humphries, Azzam Ismail, Filomena Esteves, Claire Taylor, Katherine Karakoula, Ruth Morton, Tracy Warr, Susan C. Short, Anke Brüning-Richardson   +10 more
doaj   +1 more source

Adenotonsiller Dokunun Hipertrofisinde FGFR1 Reseptörünün Rolü

, 2021
Adenotonsillar diseases are frequently encountered in ENT practice. The two most common forms of adenotonsillar disease is adenotonsillar hypertrophy leading to airway obstruction and chronic adenotonsillar inflammation.
Katar, Oğuzhan
core  

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

The prevalence of Fibroblast Growth Factor Receptor 1 Gene (FGFR1) amplification in Non-Small Cell Lung Cancer (NSCLC) by Real-time PCR [PDF]

Caspian Journal of Internal Medicine
Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients.
Sanaz Homayounfar, Hossein Ayatollahi, Gordon Ferns, Reza Hemmatan Attarbashi, Masoumeh Gharib, Maryam Sheikhi, Zahra Khoshnegah, Payam Siyadat, Amirhossein Jafarian   +8 more
doaj  

Myc-FOP-FGFR1 localizes to centriolar satellites.

, 2013
(A) Schematic of domain structure of FOP, FGFR1, and the FOP-FGFR1 fusion showing FOP LisH domain, FGFR1 kinase domains, and the translocation breakpoint.
Joanna Y. Lee (388303), Tim Stearns (106556)   +1 more
core   +1 more source

FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy

, 2020
Fondos FEDERBackground Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including ...
Quintanal Villalonga, Álvaro, Ojeda Márquez, Laura, López-Ríos Moreno, Fernando, Paz-Ares Rodríguez, Luis Gonzaga   +3 more
core   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source