Results 31 to 40 of about 6,340 (159)

Mutational identification of fibroblast growth factor receptor 1 and fibroblast growth factor receptor 2 genes in craniosynostosis in Indian population

Indian Journal of Human Genetics, 2013
The Objective of this study was to identify the association of mutation of fibroblast growth factor receptor 1 (FGFR1), FGFR2 genes with syndromic as well as non-syndromic craniosynostosis in Indian population.Retrospective analysis of our records from January 2008 to December 2012 was done.
Pandey, Rajeev Kumar, Bajpai, Minu, Ali, Abid, Gayan, Sukanya, Singh, Amit   +4 more
openaire   +3 more sources

KLB, encoding β‐Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

EMBO Molecular Medicine, 2017
Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic form of isolated gonadotropin‐releasing hormone (GnRH) deficiency caused by mutations in > 30 genes.
Cheng Xu, Andrea Messina, Emmanuel Somm, Hichem Miraoui, Tarja Kinnunen, James Acierno, Nicolas J Niederländer, Justine Bouilly, Andrew A Dwyer, Yisrael Sidis, Daniele Cassatella, Gerasimos P Sykiotis, Richard Quinton, Christian De Geyter, Mirjam Dirlewanger, Valérie Schwitzgebel, Trevor R Cole, Andrew A Toogood, Jeremy MW Kirk, Lacey Plummer, Urs Albrecht, William F Crowley, Moosa Mohammadi, Manuel Tena‐Sempere, Vincent Prevot, Nelly Pitteloud   +25 more
doaj   +1 more source

Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling. [PDF]

PLoS ONE, 2014
Coordination of cell proliferation, differentiation and survival is essential for normal development and maintenance of tissues in the adult organism.
SungKyoung Lee, Anne E Griep
doaj   +1 more source

Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism

, 2004
Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Guimond, S, Bouloux, PM, Turnbull, Jeremy, Turnbull, J, Hu, Youli, Kim, SH, Kim, Soo-Hyun, Schofield, Jonathan, Winyard, P, Winyard, Paul, Vannelli, GB, Bouloux, Pierre-Marc, Gonzalez-Martinez, D, Hu, YL, Schofield, J, Vannelli, Gabriella Barbara, González-Martínez, David, Guimond, Scott   +17 more
core   +1 more source

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source

Biology of FGFRL1, the fifth fibroblast growth factor receptor [PDF]

, 2010
FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead ...
Trueb, Beat, Beat Trueb
core   +1 more source

Fibroblast Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis

, 2012
Fibroblast Growth Factors play critical roles during development, tissue homeostasis and repair by controlling cell proliferation, survival, migration and differentiation.
Robbez-Masson, L, Ian Rosewell, Grose Richard, Cross, B, Rosewell, I, Athina-Myrto Chioni (156542), Robbez-Masson, Luisa, Rosewell Ian, Chioni Athina-Myrto, Jarosz, Monika, Barbara Cross (156544), Barbara Cross, Grose, Richard, Chioni, A-M, Rosewell, Ian, Cross Barbara, Richard Grose (156552), Chioni, Athina-Myrto, Cross, Barbara, Jarosz, M, Luisa Robbez-Masson (156539), Grose, R, Luisa Robbez-Masson, Jarosz Monika, Ian Rosewell (156548), Monika Jarosz, Richard Grose, Robbez-Masson Luisa, Monika Jarosz (156537), Athina-Myrto Chioni   +29 more
core   +1 more source

Investigating the contribution of FGF receptors in breast tumorigenesis using models of mammary cancer [PDF]

, 2010
Breast cancer, the main cancer in women, occurs in approximately 27% of all yearly diagnosed cancer cases. It is estimated that one out of eight women will develop breast cancer in her lifetime.
Dey, Julien Hervé
core   +1 more source

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

Cell Communication and Signaling, 2019
Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma membrane. FGFRs signaling needs to be precisely adjusted as aberrant FGFRs function is associated with development of human cancers or ...
Marika Kucińska, Natalia Porębska, Agata Lampart, Marta Latko, Agata Knapik, Małgorzata Zakrzewska, Jacek Otlewski, Łukasz Opaliński   +7 more
doaj   +1 more source