Fibroblast growth factor 2. [PDF]
DifferentiationFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation.
Nickle A, Ko S, Merrill AE.
europepmc +4 more sources
Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation [PDF]
FEBS Open Bio, 2023 Fibroblast growth factor (FGF) signaling plays a crucial role in lung development and repair. Fibroblast growth factor 2 (FGF2) can inhibit fibrotic gene expression and suppress the differentiation of pulmonary fibroblasts (PFs) into myofibroblasts in ...
Xiangqin Tian +7 more
doaj +2 more sources
Biological Roles of Fibroblast Growth Factor-2* [PDF]
Endocrine Reviews, 1997 I. Introduction II. Structure of FGF-2 III. Mechanisms of Action of FGF-2: Extra- and Intracellular Signaling A. Exogenous 18-kDa FGF-2 B. Endogenous 18-kDa FGF-2 and HMW FGF-2 IV. Release of FGF-2 V. Roles of FGF-2 in Development and Differentiation in Various Organ Systems A. Mesoderm induction B. Angiogenesis C. Vessel wall D. Lung E.
Andreas Bikfalvi +2 more
exaly +4 more sources
The Effects of Fibroblast Growth Factor-2 (FGF-2) on Achilles Tendon Injury [PDF]
Foot & Ankle Orthopaedics, 2023 Category: Basic Sciences/Biologics; Ankle Introduction/Purpose: Achilles tendon defects are a challenging problem, and there is a need for new treatments.
Yuki Fujikawa D(Orth) +3 more
doaj +2 more sources
Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB [PDF]
Journal of Structural Biology: XFibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye +7 more
doaj +2 more sources
Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation [PDF]
Frontiers in Chemistry, 2022 Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent ...
Rabeea Siddique +12 more
doaj +2 more sources
Glypican-1 drives unconventional secretion of fibroblast growth factor 2
eLife, 2022 Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism.
Carola Sparn +8 more
doaj +1 more source
Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells.
PLoS ONE, 2022 Heart valve disease is a growing problem worldwide. Though very common in older adults, the mechanisms behind the development of the disease aren't well understood, and at present the only therapeutic option is valve replacement.
Marcus Ground +6 more
doaj +2 more sources
Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications
Pharmaceutics, 2020 Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington +3 more
doaj +1 more source
Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study
Medicina, 2021 Background and Objectives: Aortic valve stenosis (AS) develops with a pronounced local inflammatory response, where a variety of growth factors are involved in the process, and may have a pro-inflammatory and anti-inflammatory effect.
Juris Hofmanis +9 more
doaj +1 more source