Fibroblast growth factor 2 acts as an upstream regulator of inhibition of pulmonary fibroblast activation [PDF]
FEBS Open Bio, 2023 Fibroblast growth factor (FGF) signaling plays a crucial role in lung development and repair. Fibroblast growth factor 2 (FGF2) can inhibit fibrotic gene expression and suppress the differentiation of pulmonary fibroblasts (PFs) into myofibroblasts in ...
Xiangqin Tian +7 more
doaj +4 more sources
Glypican-1 drives unconventional secretion of fibroblast growth factor 2 [PDF]
eLife, 2022 Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism.
Carola Sparn +8 more
doaj +2 more sources
Fibroblast growth factor 2. [PDF]
DifferentiationFibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation.
Nickle A, Ko S, Merrill AE.
europepmc +4 more sources
The Effects of Fibroblast Growth Factor-2 (FGF-2) on Achilles Tendon Injury [PDF]
Foot & Ankle Orthopaedics, 2023 Category: Basic Sciences/Biologics; Ankle Introduction/Purpose: Achilles tendon defects are a challenging problem, and there is a need for new treatments.
Yuki Fujikawa D(Orth) +3 more
doaj +2 more sources
Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB [PDF]
Journal of Structural Biology: XFibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye +7 more
doaj +2 more sources
Topical fibroblast growth factor‐2 for treatment of chronic tympanic membrane perforations [PDF]
Laryngoscope Investigative Otolaryngology, 2020 Objective To determine the efficacy of fibroblast growth factor‐2 (FGF‐2) in treating chronic nonhealing tympanic membrane (TM) perforations. Method Double‐blinded, randomized placebo controlled phase 2 clinical trial for patients with chronic TM ...
Felipe Santos +9 more
doaj +2 more sources
Fibroblast growth factor 2 is a druggable target against glioblastoma: A computational investigation [PDF]
Frontiers in Chemistry, 2022 Fibroblast growth factor 2 (FGF2) is a key player in cancer and tissue homeostasis and regulates renewal of several stem cell types. The FGF2 role in malignant glioma is proven and tagged FGF2, a novel druggable target, is used for developing potent ...
Rabeea Siddique +12 more
doaj +2 more sources
Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas. [PDF]
Development, 2023 El-Hodiri HM +7 more
europepmc +2 more sources
Analysis of the Effects of Five Factors Relevant to In Vitro Chondrogenesis of Human Mesenchymal Stem Cells Using Factorial Design and High Throughput mRNA-Profiling [PDF]
, 2014 The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium.
Brinchmann, Jan E. +4 more
core +18 more sources