Results 1 to 10 of about 31,503 (161)

Biphasic effects of FGF2 on adipogenesis. [PDF]

PLoS ONE, 2015
Although stem cells from mice deficient of FGF2 have been reported to display enhanced capacity for adipogenesis, the literature using in vitro cell culture system has so far reported conflicting results on the role of FGF2 in adipogenesis.
Sooho Kim, Chihoon Ahn, Naeun Bong, Senyon Choe, Dong Kun Lee   +4 more
doaj   +5 more sources

FGF2 Deficiency Modulates Early Microglial Responses Without Affecting Photoreceptor Survival in a Retinitis Pigmentosa Mouse Model [PDF]

Cells
Fibroblast growth factor 2 (FGF2) is expressed in retinal Müller glia cells, and its expression increases in response to photoreceptor degeneration. To investigate the physiological relevance of FGF2, we analyzed retinal morphology and cellular responses
Felia C. Haffelder, Nundehui Díaz-Lezama, Zeynep Okutan, Claudia Grothe, Susanne F. Koch   +4 more
doaj   +2 more sources

FGF2 alleviates LPS-induced acute lung injury by inhibiting ferritinophagy-mediated ferroptosis in AT2 cells via the Hippo-YAP signaling pathway [PDF]

Frontiers in Immunology
BackgroundFerroptosis of type II alveolar epithelial (AT2) cells plays a crucial role in the pathological progression of acute lung injury (ALI). Although fibroblast growth factor-2 (FGF2) has been shown to exert protective effects against ALI, the ...
Yan Wang, Pingjun Zhu, Yongkai Ding, Yongkai Ding, Xinjie Han, Xinjie Han, Xi Wang, Sheng Wu, Siyuan Huai, Nan Li, Guogang Xu, Guogang Xu, Guogang Xu, Yingzhen Du, Yingzhen Du   +14 more
doaj   +2 more sources

FGF2 disruption enhances thermogenesis in brown and beige fat to protect against adiposity and hepatic steatosis

Molecular Metabolism, 2021
Objective: Fibroblast growth factor 2 (FGF2) has been reported to play divergent roles in white adipogenic differentiation, however, whether it regulates thermogenesis of fat tissues remains largely unknown.
Haifang Li, Xinzhi Zhang, Hai Lin
exaly   +3 more sources

FGF2 Binding, Signaling, Angiogenesis Are Modulated by Heparanase in Metastatic Melanoma Cells

Neoplasia, 2006
Heparanase (HPSE) and fibroblast growth factor-2 (FGF2) are critical regulators of melanoma angiogenesis and metastasis. Elevated HPSE expression contributes to melanoma progression; however, further augmentation of HPSE presence can inhibit ...
Jane Reiland, Dario Marchetti
exaly   +3 more sources

FGF2 as a Potential Tumor Suppressor in Lung Adenocarcinoma. [PDF]

Diagnostics (Basel)
Background/Objectives: Lung adenocarcinoma (LUAD), the predominant subtype of non-small cell lung cancer (NSCLC), is frequently diagnosed at advanced stages with distant metastasis, underscoring the need for effective prognostic biomarkers. Fibroblast growth factor 2 (FGF2), a multifunctional regulator, has shown to play contradictory roles in cancer ...
Lin SS, Lu HY, Chang TM, Sun YS, Liu JF.
europepmc   +3 more sources

FGF2 Attenuated Inflammation-Mediated Cardiac Damage: A Novel Mechanistic Insight into the AMPK–FUNDC1–Mitophagy [PDF]

Research
Septic cardiomyopathy, a severe complication of sepsis, is characterized by high morbidity and mortality rates, and its effective management remains an important challenge.
Pingjun Zhu, Xi Wang, Xinjie Han, Yan Wang, Yongkai Ding, Min Zhu, Xin Zhang, Qian Xu, Yukun Li, Zhongxuan Li, Zhi Lu, Qi Zhang, Yan Yin, Guogang Xu, Yingzhen Du   +14 more
doaj   +2 more sources

The Effect of Altered Mucin1, FGF2, and HBEGF Gene Expression at The Ectopic Implantation Site and Endometrial Tissues in The Tubal Pregnancy Pathogenesis: A Case-Control Study [PDF]

International Journal of Fertility and Sterility, 2023
Background: Ectopic pregnancy (EP) is defined as implantation and development of an embryo outside of the uterinetissue. Women undergoing assisted reproductive technologies (ART), particularly frozen embryo transfer (FET), arein high-risk populations for
Nadia Noghrehalipour, Reza Aflatoonian, Ali Rahimipour, Samaneh Aghajanpour, Aida Najafian, Zahra Chekini, Firouzeh Ghaffari, Faranak Kazerouni   +7 more
doaj   +1 more source

Plasma membrane transbilayer asymmetry of PI(4,5)P2 drives unconventional secretion of Fibroblast Growth Factor 2 [PDF]

Nature Communications
Unconventional secretion of Fibroblast Growth Factor 2 (FGF2) is mediated by direct translocation across the plasma membrane. This process is initiated by PI(4,5)P2-dependent FGF2 oligomerization at the inner plasma membrane leaflet.
Manpreet Kaur, Fabio Lolicato, Walter Nickel   +2 more
doaj   +2 more sources

Placental vascularization in middle and late gestation in the pig

Reproduction and Fertility, 2022
The aims of this study were to determine the changes in the capillary area density in relation to fetal development, to determine immunoexpression of angiogenic factors and to compare their mRNA expression throughout pig gestation. Samples were collected
Mariana Rita Fiorimanti, Andrea Lorena Cristofolini, María José Moreira-Espinoza, María Belén Rabaglino, Claudio Gustavo Barbeito, Cecilia Inés Merkis   +5 more
doaj   +1 more source