Results 11 to 20 of about 35,769 (259)

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis [PDF]

Bioscience Reports, 2017
We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed angiogenesis and tumour growth, suggesting that R50E has potential as a therapeutic.
Mori, Seiji, Hatori, Nobuaki, Kawaguchi, Naomasa, Hamada, Yoshinosuke, Shih, Tsung-Chieh, Wu, Chun-Yi, Lam, Kit S, Matsuura, Nariaki, Yamamoto, Hirofumi, Takada, Yoko K, Takada, Yoshikazu   +10 more
openaire   +6 more sources

Single event visualization of unconventional secretion of FGF2 [PDF]

Journal of Cell Biology, 2018
FGF2 is exported from cells by an unconventional secretory mechanism. Here, we directly visualized individual FGF2 membrane translocation events at the plasma membrane using live cell TIRF microscopy. This process was dependent on both PI(4,5)P2–mediated recruitment of FGF2 at the inner leaflet and heparan sulfates capturing FGF2 at the outer plasma ...
Eleni Dimou, Katia Cosentino, Evgenia Platonova, Uris Ros, Mohsen Sadeghi, Purba Kashyap, Taxiarchis Katsinelos, Sabine Wegehingel, Frank Noé, Ana J. García-Sáez, Helge Ewers, Walter Nickel   +11 more
core   +8 more sources

Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy

Kidney International, 1997
In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies. In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline ...
Sasaki, Tamaki, Jyo, Yoshiyuki, Tanda, Nobuya, Kawakami, Yasuhiko, Nohno, Tsutomu, Tamai, Hitoshi, Osawa, Gengo   +6 more
openaire   +3 more sources

FGF2: a novel druggable target for glioblastoma? [PDF]

Expert Opinion on Therapeutic Targets, 2020
Introduction: Fibroblast growth factors (FGFs) are key mitogens in tissue homeostasis and cancer. FGF2 regulates self-renewal of multiple stem-cell types, is widely used in stem cell culture paradigms and has been adopted for cultivating the growth of cancer stem cells ex vivo.
Ana Jimenez-Pascual, Kelly Mitchell, Florian A Siebzehnrubl, Justin D Lathia   +3 more
openaire   +4 more sources

A pro‐inflammatory signature mediates FGF2‐induced angiogenesis [PDF]

Journal of Cellular and Molecular Medicine, 2008
AbstractFibroblast growth factor‐2 (FGF2) is a potent angiogenic growth factor. Here, gene expression profiling of FGF2‐stimulated microvascular endothelial cells revealed, together with a prominent pro‐angiogenic profile, a pro‐inflammatory signature characterized by the up‐regulation of pro‐inflammatory cytokine/chemokines and their receptors ...
ANDRÉS G, LEALI, Daria, MITOLA, Stefania Maria Filomena, COLTRINI, Daniela, CAMOZZI M, CORSINI M, BELLERI, Mirella, HIRSCH E, SCHWENDENER R, CHRISTOFORI G, ALCAMÍ A, PRESTA, Marco   +11 more
openaire   +5 more sources

Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson’s Disease [PDF]

International Journal of Nanomedicine
Xiaomin Wen,1,2,* Wanjun Cao,2,* Hui Ding,2 Andi Chen,2 Zhichuan Sun,2 Yazhou Wang,2 Ye Xi,2 Shengxi Wu2 1College of Life Sciences, Northwest University, Xi’an, Shaanxi, 710069, People’s Republic of China; 2Department of Neurobiology, School of ...
Wen X, Cao W, Ding H, Chen A, Sun Z, Wang Y, Xi Y, Wu S   +7 more
doaj   +1 more source

Nanodomain organization of the FGF2 secretory machinery [PDF]

, 2022
Fibroblast growth factor 2 (FGF2) is a potent mitogen involved in angiogenesis and tumor cell survival. Although a secretory protein involved in autocrine and paracrine signaling, FGF2 does not contain a signal peptide and bypasses the classical ER-Golgi-dependent route of protein secretion.
Meyer, Annalena Marie
openaire   +2 more sources

Photothermal raster image correlation spectroscopy of gold nanoparticles in solution and on live cells [PDF]

Royal Society Open Science, 2015
Raster image correlation spectroscopy (RICS) measures the diffusion of fluorescently labelled molecules from stacks of confocal microscopy images by analysing correlations within the image.
D. J. Nieves, Y. Li, D. G. Fernig, R. Lévy   +3 more
doaj   +1 more source

Up‐regulated cten by FGF2 contributes to FGF2‐mediated cell migration [PDF]

Molecular Carcinogenesis, 2013
AbstractCten is a focal adhesion molecule that is expressed at very low levels in most normal tissues. Nonetheless, its expression has been found to increase dramatically in many types of cancer including colorectal, breast, gastric, and pancreatic cancer, suggesting that cten may play a critical role during tumorigenesis.
Shih-Ya, Hung, Yi-Ping, Shih, Michelle, Chen, Su Hao, Lo   +3 more
openaire   +2 more sources

Fibroblast Growth Factor-2 Levels are Elevated in The Serum of Patients with Multiple Sclerosis [PDF]

Iranian Journal of Immunology, 2022
Background: Various factors contribute to the pathogenesis of Multiple Sclerosis (MS), one of which is Fibroblast Growth Factor 2 (FGF2). The function of FGF2 is pleiotropic.
Maryam Jari, Javad Sadeghi allah abadi, Davood Fathi, Marzieh Attar, Zahra Maleki, Majid Shahbazi   +5 more
doaj   +1 more source