Results 11 to 20 of about 38,475 (260)

Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Cell Death Discovery, 2023
We previously reported that IGFBP7 plays a role in maintaining mRNA stability of oncogenic lncRNA UBE2CP3 by RNA-RNA interaction in gastric cancer (GC). Clinical cohort studies had implied an oncogenic role of IGFBP7 in GC.
Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin   +7 more
semanticscholar   +1 more source

Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair

Autophagy, 2023
Macroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive.
M. Livingston, Ming Zhang, Sangho Kwon, Jian-Kang Chen, Honglin Li, S. Manicassamy, Zheng Dong   +6 more
semanticscholar   +1 more source

Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis

Autophagy, 2022
Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation under this condition remain elusive.
M. Livingston, Shaoqun Shu, Ying Fan, Ze Li, Q. Jiao, Xiao-Ming Yin, M. Venkatachalam, Z. Dong   +7 more
semanticscholar   +1 more source

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Signal Transduction and Targeted Therapy, 2023
Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.
Chunsik Lee, Rongyuan Chen, G. Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, H. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bibo Kang, M. Narazaki, Aaron Prodeus, L. Schoonjans, D. Ornitz, J. Gariépy, G. Eelen, M. Dewerchin, Yunlong Yang, Jing-song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, P. Carmeliet, Yihai Cao, Xuri Li   +47 more
semanticscholar   +1 more source

Placental vascularization in middle and late gestation in the pig

Reproduction and Fertility, 2022
The aims of this study were to determine the changes in the capillary area density in relation to fetal development, to determine immunoexpression of angiogenic factors and to compare their mRNA expression throughout pig gestation. Samples were collected
Mariana Rita Fiorimanti, Andrea Lorena Cristofolini, María José Moreira-Espinoza, María Belén Rabaglino, Claudio Gustavo Barbeito, Cecilia Inés Merkis   +5 more
doaj   +1 more source

YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

Genome Biology, 2021
Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear.
Xiaotang Wang, W. Fan, Na Li, Yan Ma, Mudi Yao, Guoqing Wang, Siyuan He, Wanqian Li, J. Tan, Qingjun Lu, Shengping Hou   +10 more
semanticscholar   +1 more source

Engineered autocrine signaling eliminates muscle cell FGF2 requirements for cultured meat production

bioRxiv, 2023
Cultured meat is a promising technology that faces substantial cost barriers which are currently driven largely by the price of media components. Growth factors such as fibroblast growth factor 2 (FGF2) drive the cost of serum-free media for relevant ...
Andrew J. Stout, Xiaoli Zhang, Sophia M. Letcher, Miriam L. Rittenberg, Michelle Shub, Kristin M. Chai, Maya Kaul, D. Kaplan   +7 more
semanticscholar   +1 more source

FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses

International Journal on Biological Sciences, 2023
An essential pathogenic element of acute limb ischemia/reperfusion (I/R) injury is microvascular dysfunction. The majority of studies indicates that fibroblast growth factor 2 (FGF2) exhibits protective properties in cases of acute I/R injury. Albeit its
Fan-Feng Chen, Jiayu Zhan, Mi Liu, A. Mamun, Shanshan Huang, Yibing Tao, Jiaxin Zhao, Yu Zhang, Yitie Xu, Zili He, Shenghu Du, Wei Lu, Xiaokun Li, Zimiao Chen, Jian-Feng Xiao   +14 more
semanticscholar   +1 more source

FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells

Military Medical Research, 2022
Background Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2 (FGF2) has been reported to be an inflammatory regulator; however, its role in ...
Yuanyang Tan, Huihui Zhou, Yu-jing Lin, Liutong Yi, Zhuang-gui Chen, Qing-Dong Cao, Yanrong Guo, Zhao-ni Wang, Shou-Deng Chen, Yang Li, D. Wang, Y. Qiao, Yan Yan   +12 more
semanticscholar   +1 more source

Photothermal raster image correlation spectroscopy of gold nanoparticles in solution and on live cells [PDF]

Royal Society Open Science, 2015
Raster image correlation spectroscopy (RICS) measures the diffusion of fluorescently labelled molecules from stacks of confocal microscopy images by analysing correlations within the image.
D. J. Nieves, Y. Li, D. G. Fernig, R. Lévy   +3 more
doaj   +1 more source