Results 31 to 40 of about 38,475 (260)

Mutual influence of selenium nanoparticles and FGF2-STAB® on biocompatible properties of collagen/chitosan 3D scaffolds: in vitro and ex ovo evaluation

Journal of Nanobiotechnology, 2021
In a biological system, nanoparticles (NPs) may interact with biomolecules. Specifically, the adsorption of proteins on the nanoparticle surface may influence both the nanoparticles' and proteins' overall bio-reactivity.
Johana Muchová, V. Hearnden, Lenka Michlovská, L. Vištejnová, Anna Zavadakova, Kristyna Smerkova, Silvia Kociova, V. Adam, Pavel Kopel, L. Vojtová   +9 more
semanticscholar   +1 more source

Generation and functional characterization of a single-chain variable fragment (scFv) of the anti-FGF2 3F12E7 monoclonal antibody

Scientific Reports, 2021
Single-chain variable fragments (scFvs) are small-sized artificial constructs composed of the immunoglobulin heavy and light chain variable regions connected by a peptide linker.
R. B. de Aguiar, Tábata de Almeida da Silva, B. Costa, M. Machado, R. Y. Yamada, Camila Braggion, K. R. Perez, M. Mori, Vitor Oliveira, Jane Zveiter de Moraes   +9 more
semanticscholar   +1 more source

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology, 2020
Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl   +2 more
doaj   +1 more source

Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation

Scientific Reports, 2022
Fibroblast growth factor-2 (FGF2) has multiple roles in cutaneous wound healing but its natural low stability prevents the development of its use in skin repair therapies.
Isabelle Petit, Ayelet Levy, Soline Estrach, Chloé C. Féral, Andrea Gonçalves Trentin, Florent Dingli, Damarys Loew, Jieqiong Qu, Huiqing Zhou, Clotilde Théry, Céline Prunier, Daniel Aberdam, Olivier Ferrigno   +12 more
doaj   +1 more source

FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

Nature Communications, 2020
Regulation of the programming of tumour-associated macrophages (TAMs) controls tumour growth and anti-tumour immunity. We examined the role of FGF2 in that regulation.
J. Im, Jon N. Buzzelli, K. Jones, F. Franchini, A. Gordon-Weeks, B. Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, R. Muschel   +9 more
semanticscholar   +1 more source

Healing and Angiogenic Properties of Collagen/Chitosan Scaffolds Enriched with Hyperstable FGF2-STAB® Protein: In Vitro, Ex Ovo and In Vivo Comprehensive Evaluation

Biomedicines, 2021
Wound healing is a process regulated by a complex interaction of multiple growth factors including fibroblast growth factor 2 (FGF2). Although FGF2 appears in several tissue engineered studies, its applications are limited due to its low stability both ...
L. Vojtová, V. Pavliňáková, Johana Muchová, K. Kacvinská, J. Brtnikova, M. Knoz, B. Lipovy, M. Faldyna, E. Göpfert, J. Holoubek, Z. Pavlovský, M. Vícenová, V. Blahnová, V. Hearnden, E. Filová   +14 more
semanticscholar   +1 more source

FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia

npj Regenerative Medicine, 2021
Peripheral artery disease is a progressive, devastating disease that leads to critical limb ischemia (CLI). Therapeutic angiogenesis using stem cell therapy has emerged as a promising approach for its treatment; however, adapting cell-based therapy has ...
Jungkyu Choi, Wooshik Choi, Yunji Joo, H. Chung, Dokyun Kim, S. Oh, Sang-Heon Kim   +6 more
semanticscholar   +1 more source

Dimerization capacities of FGF2 purified with or without heparin-affinity chromatography. [PDF]

PLoS ONE, 2014
Fibroblast growth factor-2 (FGF2) is a pleiotropic growth factor exhibiting a variety of biological activities. In this article, we studied the capacity of FGF2 purified with or without heparin affinity chromatography to self-associate. Analyzing the NMR
Natalia Platonova, Géraldine Miquel, Liang-Yuan Chiu, Said Taouji, Elisabetta Moroni, Giorgio Colombo, Eric Chevet, Shih-Che Sue, Andreas Bikfalvi   +8 more
doaj   +1 more source

S100A4 Is Involved in Stimulatory Effects Elicited by the FGF2/FGFR1 Signaling Pathway in Triple-Negative Breast Cancer (TNBC) Cells

International Journal of Molecular Sciences, 2021
Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype characterized by poor clinical outcome. In recent years, numerous advancements have been made to better understand the biological landscape of TNBC, though appropriate targets ...
M. Santolla, M. Talia, M. Maggiolini
semanticscholar   +1 more source

FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha. [PDF]

PLoS ONE, 2008
BACKGROUND: Fibroblast growth factor 2 (FGF2) is a major angiogenic factor involved in angiogenesis and arteriogenesis, however the regulation of its expression during these processes is poorly documented.
Caroline Conte, Elodie Riant, Céline Toutain, Françoise Pujol, Jean-François Arnal, Françoise Lenfant, Anne-Catherine Prats   +6 more
doaj   +1 more source