Results 31 to 40 of about 35,769 (259)

Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation. [PDF]

PLoS ONE, 2012
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a ...
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang   +6 more
doaj   +1 more source

Reversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene

Pharmacogenomics and Personalized Medicine, 2021
Hao Wang,1,2 Zhi-lin Sui,1 Xian-xian Wu,1 Peng Tang,1 Hong-dian Zhang,1 Zhen-tao Yu1,3 1Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin ...
Wang H, Sui Z, Wu X, Tang P, Zhang H, Yu Z   +5 more
doaj  

Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Frontiers in Cell and Developmental Biology, 2019
Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate ...
Zuzana Koledova, Zuzana Koledova, Jakub Sumbal, Jakub Sumbal, Anas Rabata, Gabin de La Bourdonnaye, Gabin de La Bourdonnaye, Radka Chaloupkova, Radka Chaloupkova, Barbara Hrdlickova, Jiri Damborsky, Jiri Damborsky, Jiri Damborsky, Veronika Stepankova   +13 more
doaj   +1 more source

The Association Between Salivary FGF2 and Physiological and Psychological Components of the Human Stress Response

Chronic Stress, 2022
Background Fibroblast Growth Factor 2 (FGF2) is a neurotrophic protein that has been implicated as a biomarker for anxiety and depressive disorders, which comprise a significant component of the global burden of disease.
Emma M. Bryant, Rick Richardson, Bronwyn M. Graham   +2 more
doaj   +1 more source

Sexually Dimorphic Regulation of MiR-29a/c-3p in Human Endothelial Cells: Cell Functions and Transcriptome. [PDF]

J Cell Physiol
ABSTRACT Preeclampsia (PE) is a major cause of maternal and fetal morbidity and mortality during pregnancy. PE is characterized by widespread endothelial dysfunction in mothers and fetuses. The etiology of PE remains elusive, but the dysregulation of microRNAs (miRNAs) in endothelial cells may contribute to the pathogenesis of PE. We have reported that
Zhang SY, Freel CI, Zhou C, Zheng J.
europepmc   +2 more sources

Effect of Endurance Training and Stem Cell on Fgf2 and Mmp13 Gene Expression in Knee Tissue of Rats with Osteoarthritis

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: The aim of this study was to investigate the effect of endurance training and stem cell injection on FGF2 and MMP13 gene expression in knee tissue of rats with knee osteoarthritis.
Mahnaz Alinejad, Alireza Barari, Asieh Abbasi Daloii, Parvin Farzanegi   +3 more
doaj  

Investigating the Involvement of Fibroblast Growth Factors in Adipose Tissue Thermogenesis

European Journal of Biology
Objective: Thermogenesis in white and brown adipose tissues can be induced by various stimuli, including cold exposure, β-adrenergic stimulation, and tumor growth.
Serkan Kır
doaj   +1 more source

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Meclozine has been developed as an inhibitor of fibroblast growth factor receptor 3 (FGFR3) to treat achondroplasia (ACH). Extracellular signal regulated kinase (ERK) phosphorylation was attenuated by meclozine in FGF2-treated chondrocyte cell line, but ...
Genta Takemoto, Genta Takemoto, Masaki Matsushita, Masaki Matsushita, Takaaki Okamoto, Toshinari Ito, Toshinari Ito, Yuki Matsuura, Chieko Takashima, Toyofumi Fengshi Chen-Yoshikawa, Hiromichi Ebi, Shiro Imagama, Hiroshi Kitoh, Hiroshi Kitoh, Kinji Ohno, Yasuyuki Hosono, Yasuyuki Hosono   +16 more
doaj   +1 more source

FGF2-induced COUP-TFII expression mediates the MEK1/2 signaling pathway.

, 2016
(A, B) C3H10T1/2 cells were pretreated with DMSO, 5 μM of U0126, 10 μM of PD98059 (PD), 5 μM of LY294002 (LY), 10 μM of SP600125 (SP), or 10 μM of SB202190 (SB) for 30 min, and then FGF2 was added at a concentration of 10 ng/mL.
Yun-Chan Hwang (2872496), Mi Nam Lee (2227909), Jeong-Tae Koh (813176), Sin-Hye Oh (2872493), Byung-Chul Jeong (813172), Jung-Woo Kim (813174)   +5 more
core   +1 more source

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

eLife, 2017
FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane.
Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel   +14 more
doaj   +1 more source