Results 41 to 50 of about 38,475 (260)

Associations of Plasma FGF2 Levels and Polymorphisms in the FGF2 Gene with Obesity Phenotypes in Han Chinese Population [PDF]

Scientific Reports, 2016
AbstractObesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear.
Ruo-Han Hao, Yan Guo, Shan-Shan Dong, Gai-Zhi Weng, Han Yan, Dong-Li Zhu, Xiao-Feng Chen, Jia-Bin Chen, Tie-Lin Yang   +8 more
openaire   +2 more sources

mRNA sequencing reveals the distinct gene expression and biological functions in cardiac fibroblasts regulated by recombinant fibroblast growth factor 2 [PDF]

PeerJ, 2023
After myocardial injury, cardiac fibroblasts (CFs) differentiate into myofibroblasts, which express and secrete extracellular matrix (ECM) components for myocardial repair, but also promote myocardial fibrosis.
Changye Sun, Mengru Bai, Yangyang Jia, Xiangqin Tian, Yonglong Guo, Xinhui Xu, Zhikun Guo   +6 more
doaj   +2 more sources

Hypoxic regulation of the expression of anti-angiogenic genes in U87 glioma cells with loss of function of ern1 signaling enzyme

Біологічні студії, 2012
The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
K. I. Kubaichuk, D. O. Minchenko, S. V. Danilovskyi, A. Y. Kuznetsova, A. K. Jassim, O. H. Minchenko   +5 more
doaj   +1 more source

Erythroid promoter confines FGF2 expression to the marrow after hematopoietic stem cell gene therapy and leads to enhanced endosteal bone formation. [PDF]

PLoS ONE, 2012
Fibroblast growth factor-2 (FGF2) has been demonstrated to be a promising osteogenic factor for treating osteoporosis. Our earlier study shows that transplantation of mouse Sca-1(+) hematopoietic stem/progenitor cells that are engineered to express a ...
Xianmei Meng, David J Baylink, Matilda Sheng, Hongjie Wang, Daila S Gridley, K-H William Lau, Xiao-Bing Zhang   +6 more
doaj   +1 more source

Reversal of Chemotherapy Resistance to Cisplatin in NSCLC by miRNA-195-5p via Targeting the FGF2 Gene

Pharmacogenomics and Personalized Medicine, 2021
Hao Wang,1,2 Zhi-lin Sui,1 Xian-xian Wu,1 Peng Tang,1 Hong-dian Zhang,1 Zhen-tao Yu1,3 1Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin ...
Wang H, Sui Z, Wu X, Tang P, Zhang H, Yu Z   +5 more
doaj  

Fibroblast Growth Factor 2 Protein Stability Provides Decreased Dependence on Heparin for Induction of FGFR Signaling and Alters ERK Signaling Dynamics

Frontiers in Cell and Developmental Biology, 2019
Fibroblast growth factor 2 (FGF2) plays important roles in tissue development and repair. Using heparan sulfates (HS)/heparin as a cofactor, FGF2 binds to FGF receptor (FGFR) and induces downstream signaling pathways, such as ERK pathway, that regulate ...
Zuzana Koledova, Zuzana Koledova, Jakub Sumbal, Jakub Sumbal, Anas Rabata, Gabin de La Bourdonnaye, Gabin de La Bourdonnaye, Radka Chaloupkova, Radka Chaloupkova, Barbara Hrdlickova, Jiri Damborsky, Jiri Damborsky, Jiri Damborsky, Veronika Stepankova   +13 more
doaj   +1 more source

Effect of Endurance Training and Stem Cell on Fgf2 and Mmp13 Gene Expression in Knee Tissue of Rats with Osteoarthritis

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2021
Introduction: The aim of this study was to investigate the effect of endurance training and stem cell injection on FGF2 and MMP13 gene expression in knee tissue of rats with knee osteoarthritis.
Mahnaz Alinejad, Alireza Barari, Asieh Abbasi Daloii, Parvin Farzanegi   +3 more
doaj  

The Association Between Salivary FGF2 and Physiological and Psychological Components of the Human Stress Response

Chronic Stress, 2022
Background Fibroblast Growth Factor 2 (FGF2) is a neurotrophic protein that has been implicated as a biomarker for anxiety and depressive disorders, which comprise a significant component of the global burden of disease.
Emma M. Bryant, Rick Richardson, Bronwyn M. Graham   +2 more
doaj   +1 more source

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Meclozine has been developed as an inhibitor of fibroblast growth factor receptor 3 (FGFR3) to treat achondroplasia (ACH). Extracellular signal regulated kinase (ERK) phosphorylation was attenuated by meclozine in FGF2-treated chondrocyte cell line, but ...
Genta Takemoto, Genta Takemoto, Masaki Matsushita, Masaki Matsushita, Takaaki Okamoto, Toshinari Ito, Toshinari Ito, Yuki Matsuura, Chieko Takashima, Toyofumi Fengshi Chen-Yoshikawa, Hiromichi Ebi, Shiro Imagama, Hiroshi Kitoh, Hiroshi Kitoh, Kinji Ohno, Yasuyuki Hosono, Yasuyuki Hosono   +16 more
doaj   +1 more source

Investigating the Involvement of Fibroblast Growth Factors in Adipose Tissue Thermogenesis

European Journal of Biology
Objective: Thermogenesis in white and brown adipose tissues can be induced by various stimuli, including cold exposure, β-adrenergic stimulation, and tumor growth.
Serkan Kır
doaj   +1 more source