Results 41 to 50 of about 35,769 (259)

A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition

Cells, 2021
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP.
Wattamon Srisakuldee, Barbara E. Nickel, Robert R. Fandrich, Feixong Zhang, Kishore B. S. Pasumarthi, Elissavet Kardami   +5 more
doaj   +1 more source

Antidepressant-like effects of intracerebroventricular FGF2 in rats [PDF]

Brain Research, 2008
The fibroblast growth factor (FGF) system is altered in post-mortem brains of individuals with major depressive disorder (MDD), but the functional relevance of this observation remains to be elucidated. To this end, we tested whether administering agents that act on FGF receptors would have antidepressant-like effects in rodents.
Cortney A, Turner, Edny L, Gula, Larry P, Taylor, Stanley J, Watson, Huda, Akil   +4 more
openaire   +2 more sources

Cholesterol: Enhancing FGF2 translocation in unconventional secretion

Journal of Cell Biology, 2022
Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to
Haodong Wang, Min Zhang, Liang Ge
openaire   +2 more sources

Exogenous FGF2 reverses depressive-like behaviors and restores the suppressed FGF2-ERK1/2 signaling and the impaired hippocampal neurogenesis induced by neuroinflammation

, 2017
Our previous work demonstrated that neuroinflammation evoked by triple repeated central LPS challenges inhibited adult hippocampal neurogenesis that were correlated with the depressive-like behavioral symptoms induced by neuroinflammation.
Jun-tao Zhang, Zhao, Ya-wei, Ming-ming Tang, Li, Ying-cong, Ying-cong Li, Tang, Ming-ming, Lin, Wen-juan, Zhang, Jun-tao, Wen-juan Lin, Ya-wei Zhao   +9 more
core   +1 more source

Efeito do FGF2 na diferenciação de células da crista neural truncal (CNT) de codornas in vitro [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Biológicas. Programa de Pós-Graduação em Neurociências.As células da crista neural (CN) têm origem a partir das bordas entre a placa neural e a epiderme durante o ...
Bittencourt, Denise Avani
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain

Cerebrospinal Fluid Research, 2010
Background Adult rat hypothalamo-pituitary axis and choroid plexus are rich in basic fibroblast growth factor (FGF2) which likely has a role in fluid homeostasis. Towards this end, we characterized the distribution and modulation of FGF2 in the human and
Gonzalez Ana M, Taylor William M, Johanson Conrad E, King Joan C, Leadbeater Wendy E, Stopa Edward G, Baird Andrew   +6 more
doaj   +1 more source

Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. [PDF]

PLoS ONE, 2018
Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals with mood disorders.
Stephanie Simard, Pragya Shail, Jessica MacGregor, Maha El Sayed, Ronald S Duman, Flora M Vaccarino, Natalina Salmaso   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cytokine supplementation influences bovine embryo transcriptome during the preimplantation period

Reproduction and Fertility
The central goal of the following studies was to understand how FGF2, LIF, and IGF1, a cocktail called ‘FLI’, influence bovine embryo development by the degree of transcriptomic variation throughout preimplantation development.
Katy S McDonald, Randall S Prather, M Sofia Ortega   +2 more
doaj   +1 more source