Results 61 to 70 of about 38,475 (260)
FGF2: a key regulator augmenting tendon-to-bone healing and cartilage repair.
Regenerative medicine, 2020 Ligament/tendon and cartilage injuries are clinically common diseases that perplex most clinicians. Because of the lack of blood vessels and nerves, their self-repairing abilities are rather poor.
Jun Zhang +9 more
semanticscholar +1 more source
Cytokine supplementation influences bovine embryo transcriptome during the preimplantation period
Reproduction and FertilityThe central goal of the following studies was to understand how FGF2, LIF, and IGF1, a cocktail called ‘FLI’, influence bovine embryo development by the degree of transcriptomic variation throughout preimplantation development.
Katy S McDonald +2 more
doaj +1 more source
Cerebrospinal Fluid Research, 2008 Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Wade Angela M +4 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Regulation of mRNA export through API5 and nuclear FGF2 interaction
Nucleic Acids Research, 2020 API5 (APoptosis Inhibitor 5) and nuclear FGF2 (Fibroblast Growth Factor 2) are upregulated in various human cancers and are correlated with poor prognosis.
S. M. Bong +12 more
semanticscholar +1 more source
FGF2 delays tectal neurogenesis, increases tectal cell numbers, and alters tectal lamination in embryonic chicks. [PDF]
PLoS ONE, 2013 Intraventricular injections of the fibroblast growth factor 2 (FGF2) are known to increase the size of the optic tectum in embryonic chicks. Here we show that this increase in tectum size is due to a delay in tectal neurogenesis, which by definition ...
Luke D McGowan +2 more
doaj +1 more source
A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses
Advanced Healthcare Materials, EarlyView.This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang +16 more
wiley +1 more source
FGF2/FGFR signaling promotes cumulus-oocyte complex maturation in vitro.
Reproduction, 2020 Fibroblast growth factor 2 (FGF2), a member of FGF family, binds with FGF receptors (FGFR) to initiate biological functions in various somatic cells. However, little is known regarding the role of FGF2/FGFR on oocyte meiosis.
C. Du +10 more
semanticscholar +1 more source
FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review
Stem Cells International, 2021 Objective. A systematic review was conducted to compare the effectiveness and safety of fibroblast growth factor-2 (FGF2) and epidermal growth factor (EGF) for regeneration of the tympanic membrane (TM). Methods.
Zhengcai Lou +3 more
doaj +1 more source