Results 81 to 90 of about 35,769 (259)

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells

Military Medical Research, 2022
Background Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2 (FGF2) has been reported to be an inflammatory regulator; however, its role in ...
Yuan-Yang Tan, Hui-Qin Zhou, Yu-Jing Lin, Liu-Tong Yi, Zhuang-Gui Chen, Qing-Dong Cao, Yan-Rong Guo, Zhao-Ni Wang, Shou-Deng Chen, Yang Li, De-Yun Wang, Yong-Kang Qiao, Yan Yan   +12 more
doaj   +1 more source

FGF2 Enhances Odontoblast Differentiation by αSMA ⁺ Progenitors In Vivo [PDF]

Journal of Dental Research, 2018
The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis.
I. Vidovic-Zdrilic, K.H. Vining, A. Vijaykumar, I. Kalajzic, D.J. Mooney, M. Mina   +5 more
openaire   +4 more sources

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli, Viktor Milkevych, Jette Feveile Young, Martin Krøyer Rasmussen   +3 more
wiley   +1 more source

FGF2 activates WNT/β-catenin signaling.

, 2012
(A) RCS cells were transfected with Topflash firefly luciferase (F-Luc) and control Renilla luciferase (R-Luc) vectors, treated with FGF2 (ng/ml), WNT3a and WNT5a (40 ng/ml) and analyzed for luciferase activity 20 hours later.
Marketa Kaucka (167847), Anie Aklian (167843), Tereza Spoustova (167888), Pavol Mikolka (167870), J. Silvio Gutkind (90145), Lukas Balek (167947), William A. Paznekas (167906), Iva Vesela (167945), William R. Wilcox (167921), Tereza Pospisilova (167878), Ethylin Wang Jabs (167931), Eva Sevcikova (167852), Joshua H. Wolf (167914), Jan Kukla Masek (167862), Vitezslav Bryja (167936), Alois Kozubik (167927), Jirina Prochazkova (167856), Pavel Krejci (167835), MaryAnn Weis (167898), Lisa Salazar (167940)   +19 more
core   +1 more source

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

The effects of KSR, Fgf2, and Egf on cultured mDMCs.

, 2016
(A) Images of cells cultured in the medium with Egf/Fgf2, KSR/Egf, KSR/Fgf2, and KSR/Egf/Fgf2. Scale bar: 50 μm. (B) The mRNA levels of some dental mesenchyme-related genes in freshly isolated (D0) mDMCs and mDMCs cultured in KSR-, KSR/Fgf2-, KSR/Egf ...
Shubin Chen (437860), Lihong Ge (2600974), Yunfei Zheng (535524), Pengfei Liu (136115), Duanqing Pei (275241), Lingfei Jia (648044), Dandan Yang (291423), Jinglei Cai (437865), Andrew Paul Hutchins (2600977), Shicheng Wei (648046)   +9 more
core   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source