Results 101 to 110 of about 35,769 (259)

Engineering Fibroblast Growth Factor‑2 (FGF2) Production in Cyanobacteria [PDF]

The Fibroblast Growth Factor 2 (FGF2) is an important signaling protein that serves to activate a variety of biological processes in animal and human cells. The FGF2 comprises an uncommon β-barrel structure composed of β-pleated sheets and loops only. It
Melis, Anastasios, Majhi, Bharat Kumar
core   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

FGF2 dimerization and competition in the N-N orientation.

, 2014
A. Top panel: assay design of the AlphaScreen™ experiment. FGF2-C-His was bound to AlphaScreen™ Ni chelate donor and acceptor beads. Bottom panel: For dimerization, increasing amounts of FGF2-C-His were incubated with the beads for 24 h before ...
Giorgio Colombo (65952), Géraldine Miquel (641821), Elisabetta Moroni (38446), Eric Chevet (71912), Said Taouji (250416), Shih-Che Sue (140516), Andreas Bikfalvi (51705), Liang-Yuan Chiu (641822), Natalia Platonova (257203)   +8 more
core   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

A biomimetic approach to modulating the sustained release of fibroblast growth factor 2 from fibrin microthread scaffolds [PDF]

Exploration of BioMat-X
Aim: The pleiotropic effect of fibroblast growth factor 2 (FGF2) on promoting myogenesis, angiogenesis, and innervation makes it an ideal growth factor for treating volumetric muscle loss (VML) injuries. While an initial delivery of FGF2 has demonstrated
Meagan E. Carnes, Cailin R. Gonyea, Jeannine M. Coburn, George D. Pins   +3 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities [PDF]

MedComm (2020)
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Yang Q, Shi J, Xu L, Zhao G, Chen Y, Cheng L, Li X, Sun Z, Huang S.   +8 more
europepmc   +2 more sources

Mifepristone inhibits MPA-and FGF2-induced mammary tumor growth but not FGF2-induced mammary hyperplasia.

Medicina, 2010
We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2) and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA) on the mouse mammary glands and to investigate whether the antiprogestin RU486 was able to reverse the ...
Cerliani, Juan Pablo, Giulianelli, Sebastian Jesus, Sahores, Ana, Wargon, Victoria, Gongora, Adrian Daniel, Baldi, Alberto, Molinolo, Alfredo, Lamb, Caroline Ana, Lanari, Claudia Lee Malvina   +8 more
openaire   +2 more sources

Fibroblast Growth Factor 2 (FGF2) in cartilage injury and repair

, 2019
Fibroblast Growth Factors (FGFs) are important pleiotropic growth factors with a proven role in joint development and postnatal homeostasis. Previously our group has shown that FGF2 is released upon cartilage injury and Fgf2 knockout (KO) mice develop ...
Khan, Sumayya Nafisa
core   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source