Results 91 to 100 of about 35,769 (259)

Sustained levels of FGF2 are achieved using PLGA microspheres.

, 2013
(A) A FACS based assay was used to measure FGF2 levels in culture. This method was sensitive at a range of concentrations and specific to FGF2. On the y-axis is Mean Fluorescence Intensity (MFI), the x-axis is concentrations of FGF2.
Ravi S. Kane (378375), Jeffrey H. Stern (378376), Steven Lotz (378367), Sally Temple (177273), Barbara Corneo (378372), Akhilesh Banerjee (378374), Christopher A. Fasano (378377), Nicolas Tokas (378369), Sarah E. Hirsch (378370), Faizzan Ahmad (378371), Susan Goderie (378368), Sheila Le (378373)   +11 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Molecular analysis of phosphorylation-dependent secretion of FGF2

, 2013
Fibroblast Growth Factor 2 (FGF2) is a potent mitogen with a prominent role in tumor-induced angiogenesis. In addition, FGF2 exerts both direct and indirect effects at the interface between angiogenesis and inflammatory processes as well as functions as ...
Laußmann, Mareike
core   +1 more source

Enrichment of Hyaluronic Acid Binding Tumor Cells by Modulation of Selective Adhesion on Microgel Surfaces

Macromolecular Rapid Communications, EarlyView.
We have developed a thermoresponsive microgel system for the selective enrichment of hyaluronic acid‐binding tumor cells. By modulating the adhesion on the microgel surface via temperature changes from 37°C to 30°C, we demonstrate a novel proof‐of‐principle for separating these tumor cell from white blood cells, which has potential applications in ...
Melanie Schmidt, Dilay Karayel, André Franken, Janita Müller, Laura Hartmann, Klaus Pantel, Tanja Fehm, Hans Neubauer, Stephan Schmidt   +8 more
wiley   +1 more source

FGF2 cooperates with IL-17 to promote autoimmune inflammation

, 2017
IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report a pathogenic
Xinrui Shao, Xiaoxia Li, Siyuan Chen, Nan Shen, Youcun Qian, Xinyang Song, Mengtao Cao, Ningli Li, Zhengxi Wu, Daping Yang, Yikun Yao   +10 more
core   +2 more sources

MIfEprIstoNE INhIBIts MpA-AND fGf2-INDuCED MAMMAry tuMor Growth But Not fGf2-INDuCED MAMMAry hypErplAsIA

, 2020
We have previously demonstrated a crosstalk between fibroblast growth factor 2 (FGF2) and progestins inducing experimental breast cancer growth. The aim of the present study was to compare the effects of FGF2 and of medroxyprogesterone acetate (MPA) on ...
Alfredo Molinolo, Caroline A Lamb, Sebastian Giulianelli, Ana Sahores, Juan P Cerliani, Victoria Wargon, Alberto Baldi, Claudia Lanari, Adrian Gongora   +8 more
core  

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents.: FGF2 Inhibition in Pulmonary Hypertension

, 2009
12 pagesInternational audiencePulmonary hypertension (PH) is a progressive, lethal lung disease characterized by pulmonary artery SMC (PA-SMC) hyperplasia leading to right-sided heart failure.
Guignabert, Christophe, Humbert, Marc, Maitre, Bernard, Gerald Simonneau, Simonneau, Gerald, Bernard Maitre, Saadia Eddahibi, Bernadette Raffestin, Serge Adnot, Elie Fadel, Fadel, Elie, Ly Tu, Mohamed Izikki, Raffestin, Bernadette, Eddahibi, Saadia, Philippe Dartevelle, Marc Humbert, Patricia Zadigue, Adnot, Serge, Dartevelle, Philippe, Christophe Guignabert, Izikki, Mohamed, Tu, Ly, Zadigue, Patricia   +23 more
core   +1 more source

PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

Neurobiology of Disease, 2005
Repair of myelin damage in the adult CNS requires oligodendrocyte progenitor (OP) proliferation and subsequent differentiation into remyelinating oligodendrocytes.
Joshua C. Murtie, Yong-Xing Zhou, Tuan Q. Le, Adam C. Vana, Regina C. Armstrong   +4 more
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source