Results 71 to 80 of about 35,769 (259)

Análise do potencial de diferenciação e autorrenovação das células da crista neural [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Neurociências, Florianópolis, 2013.A crista neural (CN) corresponde a umapopulação de células que se origina na região dorsaldo tubo ...
Bittencourt, Denise Avani
core  

FGF2 dimerization in C-N orientation.

, 2014
A. Dose-dependent proliferation of blood endothelial cells induced by recombinant FGF2-C-His and FGF2-N-GST as well as commercial FGF2. Proliferation of cells grown for 72 h was determined by Cell Proliferation Reagent WST-1.
Giorgio Colombo (65952), Géraldine Miquel (641821), Elisabetta Moroni (38446), Eric Chevet (71912), Said Taouji (250416), Shih-Che Sue (140516), Andreas Bikfalvi (51705), Liang-Yuan Chiu (641822), Natalia Platonova (257203)   +8 more
core   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Structural analysis of the stable form of fibroblast growth factor 2 – FGF2-STAB

Journal of Structural Biology: X
Fibroblast growth factor 2 (FGF2) is a signaling protein that plays a significant role in tissue development and repair. FGF2 binds to fibroblast growth factor receptors (FGFRs) alongside its co-factor heparin, which protects FGF2 from degradation.
Gabin de La Bourdonnaye, Martin Marek, Tereza Ghazalova, Jiri Damborsky, Petr Pachl, Jiri Brynda, Veronika Stepankova, Radka Chaloupkova   +7 more
doaj   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

High molecular weight FGF2 isoforms demonstrate canonical receptor-mediated activity and support human embryonic stem cell self-renewal

Stem Cell Research, 2017
Basic fibroblast growth factor (FGF2) is a highly pleiotropic member of a large family of growth factors with a broad range of activities, including mitogenesis and angiogenesis (Ornitz et al., 1996; Zhang et al., 2006), and it is known to be essential ...
Denis Kole, Alexandra Grella, David Dolivo, Lucia Shumaker, William Hermans, Tanja Dominko   +5 more
doaj   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) in human male germ cells: evidence for their expression, functionality and involvement in sperm motility regulation

, 2015
Fibroblast growth factors receptors (FGFRs) have been widely characterized in somatic cells, but there is scarce evidence of their expression and function in mammalian gametes. The objective of the present study was to evaluate the expression of FGFRs in
Mónica H. Vazquez-Levin (738258), Gongora, Adrian Daniel, Adrian Góngora (5663545), Vazquez, Monica Hebe, Marina Rosso (738255), Munuce, María José, María J. Munuce (738257), Tomás Guillardoy, Adrian Góngora, Saucedo, Lucia, Marin Briggiler, Clara Isabel, Góngora, Adrián, Lucía Saucedo, Gabriela N. Buffa (738254), Mónica H Vazquez-Levin, Clara Marín-Briggiler, Vázquez Levin, Mónica Hebe, Buffa, Gabriela Natalia, Tomás Guillardoy (738256), Gabriela N Buffa, María J Munuce, Marín Briggiler, Clara, Rosso, Marina, Lucía Saucedo (738253), Clara Marín-Briggiler (738259), Marina Rosso, Guillardoy, Tomás, Munuce, María J.   +27 more
core   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Crosstalk between FGF2 and HIF-1α.

, 2013
A. FGF2 and HIF-1α gene silencing using targeted-siRNA. 911 cells were transfected with FGF2 (left) or HIF-1α (right) targeted siRNA (siFGF2 or siHIF-1α, respectively).
Céline Toutain (88345), Elodie Riant (88344), Françoise Pujol (88346), Jean-François Arnal (83695), Françoise Lenfant (88347), Caroline Conte (88343), Anne-Catherine Prats (4523)   +6 more
core   +1 more source