Results 71 to 80 of about 38,475 (260)

Antidepressant-like effects of intracerebroventricular FGF2 in rats [PDF]

Brain Research, 2008
The fibroblast growth factor (FGF) system is altered in post-mortem brains of individuals with major depressive disorder (MDD), but the functional relevance of this observation remains to be elucidated. To this end, we tested whether administering agents that act on FGF receptors would have antidepressant-like effects in rodents.
Cortney A, Turner, Edny L, Gula, Larry P, Taylor, Stanley J, Watson, Huda, Akil   +4 more
openaire   +2 more sources

Cholesterol: Enhancing FGF2 translocation in unconventional secretion

Journal of Cell Biology, 2022
Fibroblast growth factor (FGF2) is a potent mitogen that is secreted through an unconventional secretory pathway by crossing the plasma membrane directly. In this current issue, Lolicato et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202106123) find that the secretion process is promoted by cholesterol, which enhances PI(4,5)P2 accessibility to
Haodong Wang, Min Zhang, Liang Ge
openaire   +2 more sources

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, EarlyView.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source

Expression Profiles of IGF1, EGF, and FGF2 Genes in Patients With Prostate Cancer in Isfahan Province, Iran

Research in Molecular Medicine, 2019
Background: Prostate cancer is the second most prevalent cancer among men all over the world. Over the past 10 years, prostate cancer prevalence has increased in Iran.
Farinaz Khosravian, Fatemeh Ketabchi, Nasrin Hadi, Faezeh Namazi, Mansoor Salehi   +4 more
doaj  

Overexpression of SIK2 Inhibits FGF2-dependent Müller Glial Reprogramming

Experimed
Objective: Upon injury, Müller cells re-enter the cell cycle, acquire progenitor properties, and produce new retinal neurons in zebrafish. Proliferation is an essential step in retinal regeneration.
Aslı Uğurlu Bayarslan, Kuyaş Buğra
doaj   +1 more source

Changes in glomerular epithelial cells induced by FGF2 and FGF2 neutralizing antibody in puromycin aminonucleoside nephropathy

Kidney International, 1997
In the present study, two series of experiments were done with PAN nephropathy rats given fibroblast growth factor 2 (FGF2) or FGF2 neutralizing antibodies. In the first series of experiments, a dose of 10 micrograms of FGF2 (FGF2 group), 40 micrograms of an FGF2 neutralizing antibody (Anti-FGF2 group) or an equal volume of physiological saline ...
Sasaki, Tamaki, Jyo, Yoshiyuki, Tanda, Nobuya, Kawakami, Yasuhiko, Nohno, Tsutomu, Tamai, Hitoshi, Osawa, Gengo   +6 more
openaire   +2 more sources

Vascularization of Human iPSC‐Derived Kidney Organoids Using Perfusion Culture, Pre‐Vascularized Collagen Scaffolds, and Decellularized Extracellular Matrix

Advanced Healthcare Materials, EarlyView.
An integrated perfusion‐based culture platform combining pre‐vascularized collagen scaffolds, stromal vascular fraction cells, and kidney decellularized extracellular matrix promotes vascularization of human iPSC‐derived kidney organoids. The platform provides evidence of interactions between vascular networks and glomerular‐like structures and enables
Helen Kearney, Andrea Mazzoleni, Ivan Martin, Lorenzo Moroni, Manuele Giuseppe Muraro, Carlos Mota   +5 more
wiley   +1 more source

FGF2: a novel druggable target for glioblastoma?

Expert opinion on therapeutic targets, 2020
Introduction: Fibroblast growth factors (FGFs) are key mitogens in tissue homeostasis and cancer. FGF2 regulates self-renewal of multiple stem-cell types, is widely used in stem cell culture paradigms and has been adopted for cultivating the growth of ...
Ana Jimenez-Pascual, K. Mitchell, F. Siebzehnrubl, J. Lathia   +3 more
semanticscholar   +1 more source

Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space

eLife
Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This process is initiated by phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2)-dependent formation of ...
Fabio Lolicato, Julia P Steringer, Roberto Saleppico, Daniel Beyer, Jaime Fernandez-Sobaberas, Sebastian Unger, Steffen Klein, Petra Riegerová, Sabine Wegehingel, Hans-Michael Müller, Xiao J Schmitt, Shreyas Kaptan, Christian Freund, Martin Hof, Radek Šachl, Petr Chlanda, Ilpo Vattulainen, Walter Nickel   +17 more
doaj   +1 more source

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

BMC Neuroscience, 2008
Background The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life. Previous knockout studies suggested that FGF2 plays a role in the proliferation of neural progenitors in the ...
Sanford L Philip, Doetschman Thomas, Shin Dana, Ohkubo Yasushi, Chen Kesi, Li Hongqi, Vaccarino Flora M   +6 more
doaj   +1 more source