Results 51 to 60 of about 35,769 (259)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour

Cerebrospinal Fluid Research, 2008
Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Wade Angela M, Swetloff Adam, Greenwood Sarah, Terasaki Tetsuya, Ferretti Patrizia   +4 more
doaj   +1 more source

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Stem Cells International, 2021
Objective. A systematic review was conducted to compare the effectiveness and safety of fibroblast growth factor-2 (FGF2) and epidermal growth factor (EGF) for regeneration of the tympanic membrane (TM). Methods.
Zhengcai Lou, Zihan Lou, Yumeng Jiang, Zhengnong Chen   +3 more
doaj   +1 more source

Análise dos efeitos do egf e do fgf2 sobre a diferenciação das células da crista neural truncal de codornas, in vitro [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A crista neural (CN) é uma população de células originadas das margens dorsais do tubo neural durante o desenvolvimento de vertebrados. Essas células possuem
Teixeira, Bianca Luise
core  

Confined FGF2 expression eliminates high-level FGF2 associated anemia and ameliorates extramedullary hematopoiesis.

, 2012
(a) FGF2 negatively affects body weight. Mice were weighed at 8 weeks after transplantation. GFP control vs. β-globin-FGF2, not significant; GFP control vs.
Xianmei Meng (163527), David J. Baylink (163535), Matilda Sheng (163545), Daila S. Gridley (163555), Hongjie Wang (54357), Xiao-Bing Zhang (62495), K.-H. William Lau (163565)   +6 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene

BMC Neuroscience, 2008
Background The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life. Previous knockout studies suggested that FGF2 plays a role in the proliferation of neural progenitors in the ...
Sanford L Philip, Doetschman Thomas, Shin Dana, Ohkubo Yasushi, Chen Kesi, Li Hongqi, Vaccarino Flora M   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

FGF2 delays tectal neurogenesis, increases tectal cell numbers, and alters tectal lamination in embryonic chicks. [PDF]

PLoS ONE, 2013
Intraventricular injections of the fibroblast growth factor 2 (FGF2) are known to increase the size of the optic tectum in embryonic chicks. Here we show that this increase in tectum size is due to a delay in tectal neurogenesis, which by definition ...
Luke D McGowan, Roula A Alaama, Georg F Striedter   +2 more
doaj   +1 more source

Confined FGF2 expression abrogates high-level FGF2-associated osteomalacia.

, 2012
(a) Representative illustration of Goldner's trichrome staining of femurs from each group. Green indicates mineralized bone and red or pink unmineralized bone. (b) Serum Fgf23 levels and relative Fgf23 mRNA expression in femurs from the GFP control mice,
Xianmei Meng (163527), David J. Baylink (163535), Matilda Sheng (163545), Daila S. Gridley (163555), Hongjie Wang (54357), Xiao-Bing Zhang (62495), K.-H. William Lau (163565)   +6 more
core   +1 more source