Results 51 to 60 of about 38,475 (260)

Activated FGF2 signaling pathway in tumor vasculature is essential for acquired resistance to anti-VEGF therapy

Scientific Reports, 2020
Anti–vascular endothelial growth factor (VEGF) therapy shows antitumor activity against various types of solid cancers. Several resistance mechanisms against anti-VEGF therapy have been elucidated; however, little is known about the mechanisms by which ...
Kenji Ichikawa, Saori Watanabe Miyano, Y. Minoshima, J. Matsui, Y. Funahashi   +4 more
semanticscholar   +1 more source

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

eLife, 2017
FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane.
Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel   +14 more
doaj   +1 more source

A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of FGF2 Isoforms on Permeability Transition

Cells, 2021
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP.
Wattamon Srisakuldee, Barbara E. Nickel, Robert R. Fandrich, Feixong Zhang, Kishore B. S. Pasumarthi, Elissavet Kardami   +5 more
doaj   +1 more source

A New Role for FGF2 as an Endogenous Inhibitor of Anxiety [PDF]

The Journal of Neuroscience, 2009
Human postmortem studies have demonstrated that fibroblast growth factor-2 (FGF2) expression is decreased in the brain of depressed individuals. It remained unclear, however, whether this is a consequence of the illness or whether FGF2 plays a primary role in the control of mood and emotions.
Javier A, Perez, Sarah M, Clinton, Cortney A, Turner, Stanley J, Watson, Huda, Akil   +4 more
openaire   +2 more sources

FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD)

Frontiers in Cell and Developmental Biology, 2020
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF family. It plays a role in airway remodeling associated with chronic inflammatory airway diseases, including asthma and chronic obstructive pulmonary disease (COPD ...
Yuanyang Tan, Y. Qiao, Zhuang-gui Chen, Jing Liu, Yanrong Guo, T. Tran, K. Tan, D. Wang, Yan Yan   +8 more
semanticscholar   +1 more source

Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine. [PDF]

PLoS ONE, 2018
Previous research has shown that fibroblast growth factor 2 protein (FGF2) can act as an anxiolytic and anti-depressive agent in rodents. Levels of hippocampal FGF2 and FGF2 receptors are decreased in post-mortem brains of individuals with mood disorders.
Stephanie Simard, Pragya Shail, Jessica MacGregor, Maha El Sayed, Ronald S Duman, Flora M Vaccarino, Natalina Salmaso   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Fibroblast growth factor 2 conjugated superparamagnetic iron oxide nanoparticles (FGF2-SPIONs) ameliorate hepatic stellate cells activation in vitro and acute liver injury in vivo.

Journal of Controlled Release, 2020
Liver diseases are the growing health problem with no clinically approved therapy available. Activated hepatic stellate cells (HSCs) are the key driver cells responsible for extracellular matrix deposition, the hallmark of liver fibrosis.
D. Kurniawan, Richell Booijink, L. Pater, Irene Wols, Aggelos Vrynas, G. Storm, J. Prakash, Ruchi Bansal   +7 more
semanticscholar   +1 more source

Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain

Cerebrospinal Fluid Research, 2010
Background Adult rat hypothalamo-pituitary axis and choroid plexus are rich in basic fibroblast growth factor (FGF2) which likely has a role in fluid homeostasis. Towards this end, we characterized the distribution and modulation of FGF2 in the human and
Gonzalez Ana M, Taylor William M, Johanson Conrad E, King Joan C, Leadbeater Wendy E, Stopa Edward G, Baird Andrew   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source