Results 11 to 20 of about 498,608 (348)

Biological Roles of Fibroblast Growth Factor-2* [PDF]

Endocrine Reviews, 1997
I. Introduction II. Structure of FGF-2 III. Mechanisms of Action of FGF-2: Extra- and Intracellular Signaling A. Exogenous 18-kDa FGF-2 B. Endogenous 18-kDa FGF-2 and HMW FGF-2 IV. Release of FGF-2 V. Roles of FGF-2 in Development and Differentiation in Various Organ Systems A. Mesoderm induction B. Angiogenesis C. Vessel wall D. Lung E.
A, Bikfalvi, S, Klein, G, Pintucci, D B, Rifkin   +3 more
exaly   +5 more sources

The effect of fibroblast growth factor 2 on neovascular vessels depends on the stage of angiogenesis. [PDF]

Heliyon
Hattori Y, Yamada H, Mori H, Oba S, Yokota K, Omi M, Yamamoto Y, Toyama K, Ohnaka M, Takahashi K, Imai H.   +10 more
europepmc   +2 more sources

Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells.

PLoS ONE, 2022
Heart valve disease is a growing problem worldwide. Though very common in older adults, the mechanisms behind the development of the disease aren't well understood, and at present the only therapeutic option is valve replacement.
Marcus Ground, Steve Waqanivavalagi, Young-Eun Park, Karen Callon, Robert Walker, Paget Milsom, Jillian Cornish   +6 more
doaj   +2 more sources

Prognostic Utility of Circulating Growth Factors in Aortic Valve Stenosis: A Pilot Study

Medicina, 2021
Background and Objectives: Aortic valve stenosis (AS) develops with a pronounced local inflammatory response, where a variety of growth factors are involved in the process, and may have a pro-inflammatory and anti-inflammatory effect.
Juris Hofmanis, Peteris Tretjakovs, Simons Svirskis, Gita Gersone, Dace Hofmane, Ulla Rozenberga, Leons Blumfelds, Guntis Bahs, Aivars Lejnieks, Vitolds Mackevics   +9 more
doaj   +1 more source

Fibroblast Growth Factor 2—A Review of Stabilisation Approaches for Clinical Applications

Pharmaceutics, 2020
Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/
Leah Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim   +3 more
doaj   +1 more source

Stabilisation of Recombinant Human Basic Fibroblast Growth Factor (FGF-2) against Stressors Encountered in Medicinal Product Processing and Evaluation

Pharmaceutics, 2021
Basic fibroblast growth factor (FGF-2) is a highly labile protein with strong potential for tissue engineering. The aim of this study was to develop FGF-2 formulations that are stable against physical stressors encountered in pharmaceutical processing ...
Leah R. Benington, Gunesh Rajan, Cornelia Locher, Lee Yong Lim   +3 more
doaj   +1 more source

Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes [PDF]

Arthritis Research & Therapy
Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im   +6 more
doaj   +2 more sources

Fibroblast Growth Factor-2 (FGF-2). [PDF]

Science-Business eXchange, 2009
Epileptogenesis and epilepsy progression are associated with rearrangements of neuronal circuits mediated by such processes as sprouting, neuronal cell death, and neurogenesis. These processes lead to hyperexcitability, spontaneous seizures, and/or worsening of seizure severity/frequency. Neurotrophic factors, and the Fibroblast Growth Factor-2 (FGF-2)
SIMONATO, Michele, ZUCCHINI, Silvia
openaire   +3 more sources

Circulating fibroblast growth factor-2 precipitates HIV nephropathy in mice

Disease Models & Mechanisms, 2021
People of African ancestry living with the human immunodeficiency virus-1 (HIV-1) are at risk of developing HIV-associated nephropathy (HIVAN). Children with HIVAN frequently show high plasma fibroblast growth factor-2 (FGF-2) levels; however, the role ...
Jharna R. Das, Marina Jerebtsova, Pingtao Tang, Jinliang Li, Jing Yu, Patricio E. Ray   +5 more
doaj   +1 more source

Master regulators of FGFR2 signalling and breast cancer risk. [PDF]

, 2013
The fibroblast growth factor receptor 2 (FGFR2) locus has been consistently identified as a breast cancer risk locus in independent genome-wide association studies. However, the molecular mechanisms underlying FGFR2-mediated risk are still unknown. Using
Caldas, Carlos, Castro, Mauro AA, Chin, Suet-Feung, de Santiago, Ines, Fletcher, Michael NC, Markowetz, Florian, Meyer, Kerstin B, O'Reilly, Martin, Ponder, Bruce AJ, Rueda, Oscar M, Wang, Xin   +10 more
core   +2 more sources