Results 41 to 50 of about 498,608 (348)

Fibroblast growth factor 2 control of vascular tone [PDF]

Nature Medicine, 1998
Vascular tone control is essential in blood pressure regulation, shock, ischemia-reperfusion, inflammation, vessel injury/repair, wound healing, temperature regulation, digestion, exercise physiology, and metabolism. Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes ...
M, Zhou, R L, Sutliff, R J, Paul, J N, Lorenz, J B, Hoying, C C, Haudenschild, M, Yin, J D, Coffin, L, Kong, E G, Kranias, W, Luo, G P, Boivin, J J, Duffy, S A, Pawlowski, T, Doetschman   +14 more
openaire   +2 more sources

Molecular cloning and expression of novel fibroblast growth factor-2 conjugated with immunodominant domains of pseudomonas exotoxin [PDF]

, 2015
Angiogenesis is very important in cancer growth and metastasis. Basic fibroblast growth factor (bFGF) as one of the most important angiogenesis factors is an attractive target for cancer vaccine.
Farazmandfar, T., Haghighatfard, H., Hakemi, M.G., Jadidi-Niaragh, F., Samaei, N.M., Yamchi, A., Yazdani, Y.   +6 more
core   +1 more source

Role of Lactoferrinin Fibroblast Growth Factor 2 and Vascular Endothelial Growth Factor in Gingival Wounds [PDF]

Journal of Krishna Institute of Medical Sciences University, 2019
Background: Lactoferrin possesses the ability to promote migration and proliferation of fibroblasts which represents one potential reason for the use of lactoferrin to accelerate the healing process in gingival wounds.
Istiati, Intan Nirwana, Indra Surjono, Meircurius Dwi Condro Surboyo   +3 more
doaj  

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

Journal of Translational Medicine, 2011
Background Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with
Smeland Eivind, Sorbye Sveinung W, Valkov Andrej, Kilvaer Thomas K, Bremnes Roy M, Busund Lill-Tove, Donnem Tom   +6 more
doaj   +1 more source

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice

Scientific Reports, 2021
Fibroblast growth factor 2 (FGF2) is important in musculoskeletal homeostasis, therefore the impact of reduction or Fgf2 knockout on skeletal muscle function and phenotype was determined.
C. Homer-Bouthiette, L. Xiao, Marja M. Hurley   +2 more
doaj   +1 more source

Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts* [PDF]

Endocrinology, 1999
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor with a major role in tissue morphogenesis and repair. It stimulates the proliferation of cells of the osteoblast and osteoclast lineages. Mitogenic factors playing a role in fracture repair may act by regulating HGF/SF expression or activity in bone-forming cells.
F, Blanquaert, A M, Delany, E, Canalis
openaire   +2 more sources

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Alavi A, Barbara Walzog, Bennett AM, Brooks PC, Chan RJ, Chang F, Chen J, Christian Plank, Crompton T, Cunnick JM, Distler JH, Florian Krötz, Frisch SM, Hadari YR, Hae-Young Sohn, Hanna Mannell, Hu Y, Huang P, Ivins Zito C, Kontaridis MI, Krotz F, Krotz F, Krotz F, Krotz F, Leopold Groesser, Munoz-Chapuli R, Neel BG, Neel BG, Nicole Hellwig, Noguchi T, Nor JE, Ong SH, O’Brien CD, Papetti M, Plank C, Qi JH, Qi JH, Qu CK, Ren Y, Saxton TM, Shi ZQ, Slater EP, Tang TL, Thakker GD, Tomanek RJ, Torsten Gloe, Ulrich Pohl, Wu CJ, Yart A, Zhang SQ, Zhang SQ   +50 more
core   +1 more source

Effects of Fibroblast Growth Factor-2 on Longitudinal Bone Growth* [PDF]

Endocrinology, 1998
In vivo, fibroblast growth factor-2 (FGF-2) inhibits longitudinal bone growth. Similarly, activating FGF receptor 3 mutations impair growth in achondroplasia and thanatophoric dysplasia. To investigate the underlying mechanisms, we chose a fetal rat metatarsal organ culture system that would maintain growth plate histological architecture.
E E, Mancilla, F, De Luca, J A, Uyeda, F S, Czerwiec, J, Baron   +4 more
openaire   +2 more sources