Results 61 to 70 of about 498,608 (348)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Fibroblast growth factor-2 bound to specific dermal fibroblast-derived extracellular vesicles is protected from degradation

Scientific Reports, 2022
Fibroblast growth factor-2 (FGF2) has multiple roles in cutaneous wound healing but its natural low stability prevents the development of its use in skin repair therapies.
Isabelle Petit, Ayelet Levy, Soline Estrach, Chloé C. Féral, Andrea Gonçalves Trentin, Florent Dingli, Damarys Loew, Jieqiong Qu, Huiqing Zhou, Clotilde Théry, Céline Prunier, Daniel Aberdam, Olivier Ferrigno   +12 more
doaj   +1 more source

Purified plasma membranes inhibit polypeptide growth factor-induced DNA synthesis in subconfluent 3T3 cells. [PDF]

, 1984
Plasma membranes derived from NR-6 cells, a variant line of Swiss mouse 3T3 cells that does not have cell surface receptors for epidermal growth factor (EGF), inhibited EGF-induced stimulation of DNA synthesis by 50% in serum-starved, subconfluent 3T3 ...
Fox, CF, Matiuck, NV, Peterson, SW, Vale, RD   +3 more
core  

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Fibroblast Growth Factor 2 Promotes Bladder Hypertrophy Caused by Partial Bladder Outlet Obstruction

Frontiers in Cell and Developmental Biology, 2021
Non-invasive biomarkers to identify patients with bladder outlet obstruction (BOO)-related dysfunction are still needed to guide clinical practice. The current study aims to investigate molecular alterations and biomarkers associated with partial BOO ...
Ye Gao, Peilin Liu, Fan He, Xingliang Yang, Ronghua Wu, Wei Chen, Longkun Li, Zhenxing Yang   +7 more
doaj   +1 more source

Toxicity of Flow Line, Durafill VS, and Dycal to Dental Pulp Cells: Effects of Growth Factors [PDF]

, 2010
Introduction The objective was to determine the effects of growth factor treatment on dental pulp cell sensitivity to toxicity of 2 composite restoration materials, Flow Line and Durafill VS, and a calcium hydroxide pulp capping material, Dycal ...
Furey, Alyssa, Hjelmhaug, Julie, Lobner, Doug   +2 more
core   +1 more source

Tumor Necrosis Factor - Related Apoptosis-Inducing Ligand (TRAIL) promotes angiogenesis and ischemia- induced neovascularization via NADPH Oxidase 4 (NOX4) and Nitric Oxide - dependent mechanisms [PDF]

, 2015
Background — Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has the ability to inhibit angiogenesis by inducing endothelial cell death, as well as being able to promote pro- angiogenic activity in vitro.
Azahri, N, Cartland, S, Di Bartolo, B, Gentile, C, Griffith, T, Kavurma, M, Prado-Lourenco, L, Ravindran, J, Thai, T, Thomas, S, Yeung, A   +10 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

FGFR2 (fibroblast growth factor receptor 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FGFR2 (fibroblast growth factor receptor 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources