Results 1 to 10 of about 221,633 (255)

Mutational identification of fibroblast growth factor receptor 1 and fibroblast growth factor receptor 2 genes in craniosynostosis in Indian population

Indian Journal of Human Genetics, 2013
The Objective of this study was to identify the association of mutation of fibroblast growth factor receptor 1 (FGFR1), FGFR2 genes with syndromic as well as non-syndromic craniosynostosis in Indian population.Retrospective analysis of our records from January 2008 to December 2012 was done.
Pandey, Rajeev Kumar, Bajpai, Minu, Ali, Abid, Gayan, Sukanya, Singh, Amit   +4 more
openaire   +3 more sources

Dermal fibroblast transcriptome indicates contribution of WNT signaling pathways in the pathogenesis of Apert syndrome

The Turkish Journal of Pediatrics, 2017
Cranial sutures are unossified connective tissue structures between the cranial bones, which allow expansion of these bones during development. Premature ossification of these structures is called craniosynostosis.
Arda Çetinkaya, Ekim Taşkıran, Tutku Soyer, Pelin Özlem Şimşek-Kiper, Gülen Eda Utine, Gökhan Tunçbilek, Koray Boduroğlu, Mehmet Alikaşifoğlu   +7 more
doaj   +1 more source

Regulation of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors by Transforming Growth Factor β in Human Osteoblastic MG-63 Cells [PDF]

Journal of Bone and Mineral Research, 2002
Abstract Fibroblast growth factor 2 (FGF-2) and its receptors (FGFRs) are important regulators of bone cell function. Although FGF-2 is a major modulator of bone cell function, its expression and regulation in human osteoblasts have not been investigated.
T, Sobue, T, Gravely, A, Hand, Y K, Min, C, Pilbeam, L G, Raisz, X, Zhang, D, Larocca, R, Florkiewicz, M M, Hurley   +9 more
openaire   +2 more sources

Successful Long-term Treatment with Modified Dose Pemigatinib in FGFR2-BICC1 Intrahepatic Cholangiocarcinoma: A Case Report

Journal of Cancer Research and Practice
Patients with advanced intrahepatic cholangiocarcinoma (iCCA) have a poor prognosis. Recent advances in molecular profiling offer hope by enabling targeted treatment for those with specific mutations, potentially increasing survival rates.
Kuan-Chang Lai, Ming-Huang Chen
doaj   +1 more source

Fibroblast Growth Factor-2-induced Signaling through Lipid Raft-associated Fibroblast Growth Factor Receptor Substrate 2 (FRS2) [PDF]

Journal of Biological Chemistry, 2003
The plasma membrane is not homogeneous but contains specific subcompartments characterized by their unique lipid and protein composition. Based on their enrichment in various signaling molecules, these membrane microdomains are recognized to be sites of localized signal transduction for a number of extracellular stimuli.
Marc S, Ridyard, Stephen M, Robbins
openaire   +2 more sources

A variant of fibroblast growth factor receptor 2 (Fgfr2) regulates left-right asymmetry in zebrafish.

PLoS ONE, 2011
Many organs in vertebrates are left-right asymmetrical located. For example, liver is at the right side and stomach is at the left side in human. Fibroblast growth factor (Fgf) signaling is important for left-right asymmetry.
Da-Wei Liu, Chia-Hao Hsu, Su-Mei Tsai, Chung-Der Hsiao, Wen-Pin Wang   +4 more
doaj   +1 more source

Parathyroid Hormone Regulates the Expression of Fibroblast Growth Factor-2 mRNA and Fibroblast Growth Factor Receptor mRNA in Osteoblastic Cells [PDF]

Journal of Bone and Mineral Research, 1999
Abstract We examined the effect of parathyroid hormone (PTH) on basic fibroblast growth factor-2 (FGF-2) and FGF receptor (FGFR) expression in osteoblastic MC3T3-E1 cells and in neonatal mouse calvariae. Treatment of MC3T3-E1 cells with PTH(1–34) (10–8M) or forskolin (FSK; 10–5M) transiently increased a 7 kb FGF-2 transcript with a peak ...
HURLEY M. M., TETRADIS S., HUANG Y. F., HOCK J., KREAM B. E., RAISZ L. G., SABBIETI, Maria Giovanna   +6 more
openaire   +3 more sources

Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse

Developmental Biology, 2004
Epithelial-mesenchymal interactions are critical for the formation of gastrointestinal buds such as the cecum from the midgut, but the mechanisms regulating this process remain unclear. To investigate this problem, we have studied the temporal and spatial expression of key genes known to orchestrate branching morphogenesis.
Burns, R.C, Fairbanks, T.J, Sala, F, De Langhe, S, Mailleux, A, Thiery, J.P, Dickson, C, Itoh, N, Warburton, D, Anderson, K.D, Bellusci, S   +10 more
openaire   +2 more sources

Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis

Redox Biology
Helicobacter pylori (H. pylori) is the leading risk factor for gastric carcinogenesis. Fibroblast growth factor receptor 4 (FGFR4) is a member of transmembrane tyrosine kinase receptors that are activated in cancer.
Mohammed Soutto, Xing Zhang, Nadeem Bhat, Zheng Chen, Shoumin Zhu, Selma Maacha, Melanie Genoula, Omar El-Gazzaz, Dunfa Peng, Heng Lu, Oliver G. McDonald, Xi Steven Chen, Longlong Cao, Zekuan Xu, Wael El-Rifai   +14 more
doaj   +1 more source

Increase Fibroblast Activation Protein-α, but not Lowering of FGF Receptor and/or Co-Receptor, Causes Increase in Fibroblast Growth Factor-21 in T2D Independent on Diabetes Duration [PDF]

Ain Shams Medical Journal
Background: Diabetes mellitus is a major global public health issue. T2DM patients are associated with increased Fibroblast growth Factor 21 (FGF21).
Ghofran Kamel, Ahmed Alshawi
doaj   +1 more source