Results 21 to 30 of about 221,633 (255)

Structure-based drug-development study against fibroblast growth factor receptor 2: molecular docking and Molecular dynamics simulation approaches [PDF]

Scientific Reports
Developing new therapeutic strategies to target specific molecular pathways has become a primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) is a critical signaling protein involved in various cellular processes ...
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan   +5 more
doaj   +2 more sources

The Prognostic Significance and Co-Expression of Fibroblast Growth Factor Receptor 2 and c-Met in Endometrial Cancer [PDF]

International Journal of Women's Health
Huiqiao Gao, Qi Lu, Jianxin Zhang Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, 100020, People’s Republic of ChinaCorrespondence: Jianxin Zhang, Email Jianxin20241031@126 ...
Gao H, Lu Q, Zhang J
doaj   +2 more sources

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +2 more sources

A case of Pfeiffer syndrome with c833_834GC>TG (Cys278Leu) mutation in the gene [PDF]

Korean Journal of Pediatrics, 2010
Pfeiffer syndrome is a rare autosomal dominant disorder characterized by coronal craniosynostosis, brachycephaly, mid-facial hypoplasia, and broad and deviated thumbs and great toes.
Min Young Lee, Ga Won Jeon, Ji Mi Jung, Jong Beom Sin   +3 more
doaj   +1 more source

Fibroblast Growth Factors 1 and 2 and Fibroblast Growth Factor Receptor 1 Are Elevated in Thyroid Hyperplasia [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1998
We have previously reported increased expression of fibroblast growth factor (FGF-1 and FGF-2) in benign and malignant human thyroid neoplasia. To determine the role of these factors in thyroid hyperplasia we have examined their expression in multinodular goiter and compared findings with those in normal thyroid tissue. Because the effects of FGF-1 and
S D, Thompson, J A, Franklyn, J C, Watkinson, J M, Verhaeg, M C, Sheppard, M C, Eggo   +5 more
openaire   +2 more sources

Role of Fibroblast Growth Factor Receptor 2 in Kidney Mesenchyme [PDF]

Pediatric Research, 2008
Conditional deletion of murine fibroblast growth factor receptors (Fgfrs) 1 and 2 in metanephric mesenchyme leads to renal agenesis with unbranched ureteric buds; however, there are occasionally two buds per nephric duct. Our goal was to determine whether conditional deletion of Fgfr1 or Fgfr2 alone resulted in multiple ureteric bud induction sites ...
David, Hains, Sunder, Sims-Lucas, Kayle, Kish, Monalee, Saha, Kirk, McHugh, Carlton M, Bates   +5 more
openaire   +2 more sources

A Case of Pulmonary Tumor Thrombotic Microangiopathy Suggested by the Presence of Tumor Cells in Peripheral Blood

Case Reports in Oncology, 2020
Pulmonary tumor thrombotic microangiopathy (PTTM) is characterized by tumor cell microemboli with occlusive fibrointimal remodeling in small pulmonary vessels.
Yusuke Kawanaka, Hisato Kawakami, Shigeki Shimizu, Takeshi Yoshida, Hidetoshi Hayashi, Kazuto Nishio, Takao Satou, Kazuhiko Nakagawa   +7 more
doaj   +1 more source

Durable response from fibroblast growth factor receptor inhibition in intrahepatic cholangiocarcinoma terminated by metachronous acute myeloid leukemia: a case report

Journal of Medical Case Reports, 2023
Introduction Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a ...
Andreas Edwin Juarso, Stefanie Entz, Florian Weissinger   +2 more
doaj   +1 more source

Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma [PDF]

Molecular Cancer Research, 2009
Abstract We report that 10% of melanoma tumors and cell lines harbor mutations in the fibroblast growth factor receptor 2 (FGFR2) gene. These novel mutations include three truncating mutations and 20 missense mutations occurring at evolutionary conserved residues in FGFR2 as well as among all four FGFRs.
Gartside, Michael G., Chen, Huaibin, Ibrahimi, Omar A., Byron, Sara A., Curtis, Amy V., Wellens, Candice L., Bengston, Ana, Yudt, Laura M., Eliseenkova, Anna V., Ma, Jinghong, Curtin, John A., Hyder, Pilar, Harper, Ursula L., Riedesel, Erica, Mann, Graham J., Trent, Jeffrey M., Bastian, Boris C., Meltzer, Paul S., Mohammadi, Moosa, Pollock, Pamela M.   +19 more
openaire   +3 more sources

Fibroblast growth factor receptor-2 expression in thyroid tumor progression: potential diagnostic application. [PDF]

PLoS ONE, 2013
Fibroblast growth factor receptor-2 (FGFR-2) plays an important role in tumorigenesis. In thyroid cancer it has been observed a FGFR-2 down-modulation, but the role of this receptor has not been yet clarified.
Adriano Redler, Giorgio Di Rocco, Domenico Giannotti, Francesca Frezzotti, Maria Giulia Bernieri, Simona Ceccarelli, Sirio D'Amici, Enrica Vescarelli, Anna Paola Mitterhofer, Antonio Angeloni, Cinzia Marchese   +10 more
doaj   +1 more source