Epitope Swapping to Distinguish Transgenic from Endogenous Fibroblast Growth Factor Receptor Type 1 [PDF]
BioTechniques, 2000 Fen Wang
doaj +3 more sources
The transcriptional atlas, intercellular communication, and metabolic reprogramming of the cartilage and synovium in osteoarthritis patients with diabetes mellitus: a multiomics study [PDF]
Bone & Joint ResearchAims: A strong correlation has been observed between diabetes mellitus (DM) with the pathogenesis of osteoarthritis (OA). This study aimed to elucidate the cellular and molecular mechanisms by which DM exacerbates OA, through multiomics analysis of ...
Yinxian Wen +9 more
doaj +2 more sources
VAP1 promotes cardiac fibrosis by enabling PDGFR signaling in myofibroblasts [PDF]
Experimental and Molecular MedicineExcessive fibrogenesis is associated with adverse cardiac remodeling and heart failure. Myofibroblast, primarily derived resident fibroblast, is the effector cell type in cardiac fibrosis.
Shan Huang +9 more
doaj +2 more sources
Immunological mechanisms and therapeutic approaches in pulmonary fibrosis [PDF]
European Respiratory ReviewPulmonary fibrosis (PF), the irreversible scarring of the lungs in many interstitial lung diseases, remains fatal despite currently approved antifibrotic therapy. Converging evidence shows that dysregulated innate and adaptive immunity orchestrates every
Laurine M. Nell +4 more
doaj +2 more sources
Pivotal Role of TGF-β/Smad Signaling in Cardiac Fibrosis: Non-coding RNAs as Effectual Players
Frontiers in Cardiovascular Medicine, 2021 Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions, known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the heart muscle.
Somayeh Saadat +10 more
doaj +1 more source
The fibroblast growth factor receptor is not required for herpes simplex virus type 1 infection [PDF]
Journal of Virology, 1992 The early events mediating herpes simplex virus type 1 (HSV-1) infection include virion attachment to cell surface heparan sulfates and subsequent penetration. Recent evidence has suggested that the high-affinity fibroblast growth factor (FGF) receptor mediates HSV-1 entry. This report presents three lines of experimental evidence showing that the high-
D P, Mirda +5 more
openaire +2 more sources
Autocrine Signaling in Cardiac Remodeling: A Rich Source of Therapeutic Targets
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 The myocardium consists of different cell types, of which endothelial cells, cardiomyocytes, and fibroblasts are the most abundant. Communication between these different cell types, also called paracrine signaling, is essential for normal cardiac ...
Vincent F. M. Segers +1 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Pulmonary fibrosis is a group of life-threatening diseases with limited therapeutic options. The involvement of cannabinoid type 1 receptors (CB1R) has been indicated in fibrotic diseases, but whether or not the activation of CB1R can be a benefit for ...
Dongxin Chen +6 more
doaj +1 more source
Cardiotrophin-1 Stimulation of Cardiac Fibroblast Growth [PDF]
Circulation Research, 2002 Cardiotrophin-1 (CT-1), a member of the interleukin-6 superfamily, and endothelin-1 (ET-1) are potent hypertrophic factors in cardiomyocytes. Although CT-1 and ET-1 gene expression in the heart is upregulated in experimental heart failure, their role in the activation of the cardiac fibroblast is unknown.
Toshihiro, Tsuruda +9 more
openaire +2 more sources
β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. [PDF]
PLoS ONE, 2012 The adhesion receptor β3 integrin regulates diverse cellular functions in various tissues. As β3 integrin has been implicated in extracellular matrix (ECM) remodeling, we sought to explore the role of β3 integrin in cardiac fibrosis by using wild type ...
Sundaravadivel Balasubramanian +8 more
doaj +1 more source