Results 11 to 20 of about 221,633 (255)

Functional Distinctions of Endometrial Cancer-Associated Mutations in the Fibroblast Growth Factor Receptor 2 Gene [PDF]

Cells, 2023
Functional analysis of somatic mutations in tumorigenesis facilitates the development and optimization of personalized therapy for cancer patients. The fibroblast growth factor receptor 2 (FGFR2) gene is frequently mutated in endometrial cancer (EC), but
Garima Dixit, Benjamin A. Pappas, Gourav Bhardwaj, Willow Schanz, Thorsten Maretzky   +4 more
doaj   +2 more sources

Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling [PDF]

Clinical and Translational Medicine
Background Metabolic dysfunction–associated steatotic liver disease (MASLD) and advanced fibrotic stages are significant contributors to cirrhosis and liver‐related mortality, yet no therapies directly target fibrosis in the later stages of the disease ...
Xuanxin Yang, Qingqing Dong, Jiaying Ma, Yawei Yan, Shuangyan Peng, Qiqi Wu, Huan Wang, Tingting Zhang, Panyu Zhang, Zelong Jiang, Chao Lu, Le Li, Xinyi You, Yuandong Xu, Joshua Banda, Zhixiang Mu, Minghua Zheng, Xiaokun Li, Qi Hui, Bingjie Yu, Xiaojie Wang   +20 more
doaj   +2 more sources

2H-pyrazolo[3,4-d]pyrimidin-4-amine derivatives as novel selective fibroblast growth factor receptor 2 (FGFR2) inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Although FGFR2 is a well-validated oncogenic target, no selective FGFR2 inhibitors have been approved for clinical use. In this study, we report the discovery of 2H-pyrazolo[3,4-d]pyrimidin-4-amine derivative as novel, irreversible FGFR2 inhibitors.
Pinglian Wu, Zhaodi Tian, Weizhong Shen, Qiuju Xun, Yuan Tian, Huiqiong Li, Bowen Yang, Shaohua Chang, Weixue Huang, Zhen Wang, Ke Ding, Dawei Ma   +11 more
doaj   +2 more sources

Role of Fibroblast Growth Factor Receptor 2 (FGFR2) in Corneal Stromal Thinning. [PDF]

Invest Ophthalmol Vis Sci, 2023
To determine the role of fibroblast growth factor receptor 2 (FGFR2)-mediated signaling in keratocytes during corneal development, a keratocyte-specific FGFR2-knockout (named FGFR2cKO) mouse model was generated, and its phenotypic characteristics were determined.A FGFR2cKO mouse model was generated by the following method: FGFR2 flox mice were crossed ...
Joseph R, Boateng A, Srivastava OP, Pfister RR.   +3 more
europepmc   +3 more sources

Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer. [PDF]

Int J Biol Sci, 2017
Fibroblast growth factor receptor 2 (FGFR2) is a membrane-spanning tyrosine kinase that mediates signaling for FGFs. Recent studies detected various point mutations of FGFR2 in multiple types of cancers, including breast cancer, lung cancer, gastric cancer, uterine cancer and ovarian cancer, yet the casual relationship between these mutations and ...
Lei H, Deng CX.
europepmc   +4 more sources

Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection. [PDF]

PLoS ONE, 2020
BackgroundHepatocellular carcinoma (HCC) recurrence after liver resection depends upon the stage and histological grade of the tumor and the expression of certain biomarkers.
Baek Gyu Jun, Woong Cheul Lee, Jae Young Jang, Soung Won Jeong, Young Chang, Sae Hwan Lee, Young Don Kim, Sang Gyune Kim, Gab Jin Cheon, Young Seok Kim, Hong Soo Kim, So Young Jin   +11 more
doaj   +2 more sources

The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor [PDF]

Cell Communication and Signaling, 2010
Background The fibroblast growth factor receptor (FGFR) interprets concentration gradients of FGF ligands and structural changes in the heparan sulfate (HS) co-receptor to generate different cellular responses.
Duchesne Laurence, Zhu Hongyan, Rudland Philip S, Fernig David G   +3 more
doaj   +3 more sources

Fibroblast growth factor receptor 2 (FGFR2) genetic polymorphisms contribute to fused roots in human molars. [PDF]

PLoS ONE
Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects tooth formation and patients with FGFR2 mutations often present dental anomalies in the spectrum of the syndrome.
Sandra Regina Santos Meyfarth, Flares Baratto-Filho, Maria Eduarda Nunis Locks, Peter Proff, Giordano Oliveira Zandoná, Thaís de Oliveira Fernandes, Paulo Henrique Condeixa de França, Christian Kirschneck, Leonardo Santos Antunes, Erika Calvano Küchler   +9 more
doaj   +2 more sources

The Role of Fibroblast Growth Factor Receptor 2 as A Prognostic Biomarker in Colorectal Adenocarcinoma. [PDF]

Asian Pac J Cancer Prev
This study aimed to analyze the correlation between fibroblast growth factor receptor 2 (FGFR2) expression with the histopathological grade, tumor budding grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma.This study used a cross-sectional design. Immunohistochemistry was performed on one hundred slides from paraffin-
Rianti AM, Miskad UA, Cangara MH, Wahid S, Achmad D, Tawali S.   +5 more
europepmc   +3 more sources

Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma. [PDF]

Curr Opin Gastroenterol, 2015
This review will cover the role of the fibroblast growth factor pathway in the pathogenesis, targeted therapy potential and prognostic value in patients with cholangiocarcinoma (CCA).Recent studies that have identified fibroblast growth factor receptor 2 (FGFR2) fusions, prognostic implications of FGFR2 fusions, treatment strategies that target FGFR2 ...
Borad MJ, Gores GJ, Roberts LR.
europepmc   +4 more sources