Results 41 to 50 of about 6,340 (159)

Fibroblast growth factor receptor 1 amplification in non-small cell lung cancer by quantitative real-time PCR. [PDF]

PLoS ONE, 2013
Amplification of the fibroblast growth factor receptor 1 (FGFR1) gene has been described in tumors of non-small-cell lung cancer (NSCLC) patients. Prior reports showed conflicting rates of amplification frequency and clinical relevance.We developed a ...
Shirish M Gadgeel, Wei Chen, Michele L Cote, Aliccia Bollig-Fischer, Susan Land, Ann G Schwartz, Gerold Bepler   +6 more
doaj   +1 more source

Protein kinase B inhibitors enhance the sensitivity of translocated promoter region–fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis

Journal of International Medical Research
Objective Fibroblast growth factor receptor 1 (FGFR1) inhibitors are considered effective for treating 8p11 myeloproliferative syndrome. However, targeting FGFR1 alone may be inadequate for patients with translocated promoter region (TPR)–FGFR1 ...
Mengyao Lv, Wenbing Shangguan, Qian Zhao, Yan Li, Quan Zhao, Feng Li   +5 more
doaj   +1 more source

Phosphate-sensing mechanisms and functions of phosphate as a first messenger

Endocrine Journal
Bone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of ...
Yuichi Takashi
doaj   +1 more source

FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla [PDF]

, 2009
Association pour la Recherche contre le Cancer, Centre National de la Recherche Scientifique, the European Molecular Biology Organization, and the Cascade network of excellence in the 6th Framework Programme for financial support. The laboratory of HE is
Garcia-Fernandez Jordi, Somorjai, Ildiko, Garcia-Fernandez, Jordi, Escriva Hector, Bertrand Stephanie, Lamonerie, Thomas, Escriva, Hector, Lamonerie Thomas, Somorjai Ildiko, Bertrand, Stephanie   +9 more
core   +1 more source

Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts [PDF]

, 2014
Aims: Fibroblast growth factor 21 (FGF21) is a hepatic metabolic regulator with pleotropic actions. Its plasma concentrations are increased in obesity and diabetes; states associated with an increased incidence of cardiovascular disease.
Muhammad F Bari, Bari Muhammad F., Jing Chen, Edward W. Hillhouse (519261), Bari, Muhammad F., Raghu Adya (519258), Patel Vanlata, Bhudia, Sunil K., Edward W Hillhouse, Harpal S Randeva, Vanlata Patel, Raghu Adya, Chen Jing, Manjunath Ramanjaneya, Bee K. Tan (417731), Ramanjaneya, Manjunath, Jing Chen (4762), Patel, Vanlata H., Ramanjaneya Manjunath, Harpal S. Randeva (417734), Randeva Harpal S., Muhammad F. Bari (417733), Tan, Bee K., Adya Raghu, Adya, Raghu, Tan Bee K., Bhudia Sunil K., Randeva, Harpal S., Bee K Tan, Manjunath Ramanjaneya (519259), Sunil K Bhudia, Sunil K. Bhudia (519260), Hillhouse Edward W., Vanlata Patel (519257), Hillhouse, Edward W., Chen, Jing   +35 more
core   +1 more source

Future perspectives: targeting fibroblast growth factor receptor 1 to enhance the efficacy of immunotherapy [PDF]

Exploration of Targeted Anti-tumor Therapy
Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in the progression of various cancers through its involvement in cell proliferation, survival, and differentiation.
Ilya Tsimafeyeu
doaj   +1 more source

Biomarkers for gastric cancer: molecular classification revisited [PDF]

Precision and Future Medicine, 2017
Gastric cancer (GC) is one of the most common lethal cancer worldwide. In recent years, several new targeted therapeutic agents for the treatment of metastatic GC have been developed.
Jeeyun Lee, Kyoung-Mee Kim
doaj   +1 more source

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

Journal of Biological Chemistry, 1992
A truncated form of the type 1 fibroblast growth factor receptor (FGFR1) lacking most of its cytoplasmic domain was tested for its ability to inhibit signal transduction by each of three different wild-type FGFRs (FGFR1, 2, and 3). When the truncated FGFR1 was expressed in Xenopus oocytes in excess of each wild-type FGFR, mobilization of intracellular ...
H, Ueno, M, Gunn, K, Dell, A, Tseng, L, Williams   +4 more
openaire   +2 more sources

Selection of Peptide Ligands Binding to Fibroblast Growth Factor Receptor 1 [PDF]

IUBMB Life, 2002
AbstractInappropriate expression of fibroblast growth factors (FGFs) or activation of FGF receptors (FGFRs) could contribute to several human angiogenic pathologies. In an attempt to design antagonists of FGF, we developed a screening procedure for identifying peptide ligands binding to FGFR1.
Hongkuan, Fan, Yanfen, Duan, Hui, Zhou, Wei, Li, Fei, Li, Lili, Guo, Roger W, Roeske   +6 more
openaire   +2 more sources

(3,5-Dimethylpyrazol-1-yl)-[4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl]methanone

Molbank, 2016
In an attempt to enhance cytotoxic activity of pyrazolo[3,4-d]pyrimidine core, we synthesized (3,5-dimethylpyrazol-1-yl)-[4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)phenyl]methanone (4) by reacting 4-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)
Rania B. Bakr, Ahmed B. M. Mehany
doaj   +1 more source