Results 61 to 70 of about 6,340 (159)

Global Developmental Gene Programing Involves a Nuclear Form of Fibroblast Growth Factor Receptor-1 (FGFR1). [PDF]

PLoS ONE, 2015
Genetic studies have placed the Fgfr1 gene at the top of major ontogenic pathways that enable gastrulation, tissue development and organogenesis. Using genome-wide sequencing and loss and gain of function experiments the present investigation reveals a ...
Christopher Terranova, Sridhar T Narla, Yu-Wei Lee, Jonathan Bard, Abhirath Parikh, Ewa K Stachowiak, Emmanuel S Tzanakakis, Michael J Buck, Barbara Birkaya, Michal K Stachowiak   +9 more
doaj   +1 more source

Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c [PDF]

Journal of Biological Chemistry, 2017
A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c. The HS polysaccharide tested contained both undersulfated (NA) domains and highly sulfated (NS) domains as well as
Victor, Schultz, Mathew, Suflita, Xinyue, Liu, Xing, Zhang, Yanlei, Yu, Lingyun, Li, Dixy E, Green, Yongmei, Xu, Fuming, Zhang, Paul L, DeAngelis, Jian, Liu, Robert J, Linhardt   +11 more
openaire   +2 more sources

Moxibustion inhibits growth of tumor by down-regulating expression of FGFR1 and VEGFR2 in mice with sarcoma

针刺研究, 2021
Objective To observe the effect of moxibustion on the growth of tumor and expression of fibroblast growth factor receptor 1(FGFR1) and vascular endothelial cell growth factor receptor 2(VEGFR2) in mice with sarcoma, so as to explore its mechanisms ...
LI Li-jun, LUO Min-xiang, HE Li-jiao, ZHAO Chang-lin   +3 more
doaj  

Impairment of sperm motility in mice with heterozygous deletion of fibroblast growth factor receptor 1 [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of heterozygous deletion of fibroblast growth factor receptor 1 (FGFR1) on reproductive function in congenital hypogonadotropic hypogonadism (CHH).
LI Chenyang, LI Ting, WANG Xi, NIE Min, WU Xueyan, MAO Jiangfeng, HAN Qin
doaj   +1 more source

Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud

Developmental Biology, 2004
Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development. To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach.
Zhao, Haotian, Kegg, Heather, Grady, Sandy, Truong, Hoang-Trang, Robinson, Michael L., Baum, Michel, Bates, Carlton M.   +6 more
openaire   +2 more sources

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients

, 2001
Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud's phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin fibrosis.
Stratton, R, Thomas Haberberger, Carol M. Black, Haberberger, T, Xu Shiwen, Martini, G, Holmes, A, Alan Holmes, Andrew Leask, Shiwen, X, David Abraham, Black, CM, Leask, A, Martin, GR, Abraham, D, George R. Martin, Richard Stratton, Giorgia Martini   +17 more
core   +1 more source

Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme

Developmental Biology, 2006
To determine the importance of fibroblast growth factor receptors (fgfrs) 1 and 2 in the metanephric mesenchyme, we generated conditional knockout mice (fgfr(Mes-/-)). Fgfr1(Mes-/-) and fgfr2(Mes-/-) mice develop normal-appearing kidneys. Deletion of both receptors (fgfr1/2(Mes-/-)) results in renal aplasia. Fgfr1/2(Mes-/-) mice develop a ureteric bud (
Poladia, Deepali Pitre, Kish, Kayle, Kutay, Benjamin, Hains, David, Kegg, Heather, Zhao, Haotian, Bates, Carlton M.   +6 more
openaire   +2 more sources

Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells

Cells
The Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF ...
Barbara Hausott, Lena Pircher, Michaela Kind, Jong-Whi Park, Peter Claus, Petra Obexer, Lars Klimaschewski   +6 more
doaj   +1 more source

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source

New derivatives based on zerumbone scaffold as anticancer inhibitors: Synthesis, in vitro anticancer evaluation, docking, and MD simulation studies

Journal of Chemical Research
A three-step procedure was applied to synthesize seven novel zerumbone ethers 7a–g with N -(4-hydroxybenzyl) benzamide, N -(4-hydroxybenzyl) substituted benzamide, and N -(4-hydroxybenzyl) cinnamamide moieties, including simultaneous O - and N ...
Ngoc Hung Truong, Minh Ha Le, Hanh Trang Luu, Tien Chinh Vu, Van Chung Pham, Van Chinh Luu   +5 more
doaj   +1 more source