Results 81 to 90 of about 6,340 (159)

Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization [PDF]

, 1996
Producción CientíficaU2OS Dr1 cells, originating from a human osteosarcoma, are resistant to the intracellular action of diphtheria toxin but contain toxin receptors on their surfaces.
Wiedlocha, Antoni, Falnes, Pål, Klingenberg, Olav, Rapak, Andrzej, Olsnes, Sjur, Muñoz Martínez, Raquel   +5 more
core   +1 more source

A Detailed Protocol for Large-scale Recombinant Expression and Validation of Human FGFR2 with Its Transmembrane and Extracellular Domains in Escherichia coli

Bio-Protocol, 2019
Receptor tyrosine kinases (RTKs) are an important class of transmembrane receptors that mediate some of the most crucial biochemical pathways essential to the growth, differentiation, and survival of a cell and thus, are highly involved in cancers.
Adam Bajinting, Ho Ng
doaj   +1 more source

Protein recruitment to receptor tyrosine kinase-mediated early signalling complexes.

, 2007
Receptor tyrosine kinase (RTK) signalling regulates the activation of numerous cellular processes in response to various external stimuli. Spatio-temporal regulation of protein recruitment to activated tyrosine kinase receptors is important for the ...
Schller, A.C.
core  

Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium

, 2001
Basic fibroblast growth factor (FGF2) stimulates proliferation of the globose basal cells, the neuron:ll precursor in the olfactory epithelium. The present study investigates the expression of basic fibroblast growth factor and fibroblast growth factor ...
Pickles, J. O., Mackay-Sim, A, James O Pickles, Kyra Sneesby, Pi-en Hsu, Yu, F, Hsu, Pi-en, Woods, Kyra, Mackay-Sim, Alan, Feron, F., Pickles, James, Mackay-Sim, A., François Féron, Hsu, P, Sneesby, K, Sneesby, K., Alan Mackay-Sim, Feron, Francois, Yu, Fu, Yu, F., Fu Yu, Pickles, JO, Feron, F, Hsu, P.   +23 more
core   +1 more source

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Groesser, Leopold, Walzog, Barbara, Gloe, Torsten, Sohn, Hae-Young, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Hellwig, Nicole, Mannell, Hanna   +8 more
core   +1 more source

FGF and TGFbeta signalling in an in-vitro model of craniosynostosis

, 2009
Fibroblast Growth Factor (FGF) and Transforming Growth Factor beta (TGFbeta) are key regulators of bone development. Constitutively activating mutations of FGF Receptors (FGFR) 1-3 result in craniosynostosis, premature fusion of cranial sutures.
Lee, K.M.A.
core  

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina, Dono, Rosanna, Schindowski, Katharina, Krause, Sonja, Bohlen und Halbach, Oliver von, Schwaninger, Markus, Unsicker, Klaus   +6 more
core   +1 more source

A mass action model of a fibroblast growth factor signaling pathway and its simplification

, 2008
We consider a kinetic law of mass action model for Fibroblast Growth Factor (FGF) signaling, focusing on the induction of the RAS-MAP kinase pathway via GRB2 binding.
Gaffney, Eamonn, Heath, John, Gaffney, E. A., Kwiatkowska, M Z, Heath, J K, Gaffney, E A, Heath, JK, Kwiatkowska, MZ   +7 more
core   +1 more source

Tumor-stroma derived gene expression patterns as prognosticators in breast cancer [PDF]

, 2010
The stroma, which embeds epithelial cells, plays a major role in the shaping and physiological regulation of animal organs such as the breast. Aberrant functioning of the stroma was found to support tumorigenesis and cancer progression.
Rajski, Michal
core   +1 more source

Fibroblast growth factors 1 and 2 differently activate MAP kinase in Xenopus oocytes expressing fibroblast growth factor receptors 1 and 4

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001
The mitogen-activated protein kinase (MAP kinase) signalling cascade activated by fibroblast growth factors (FGF1 and FGF2) was analysed in a model system, Xenopus oocytes, expressing fibroblast growth factor receptors (FGFR1 and FGFR4). Stimulation of FGFR1 by FGF1 or FGF2 and FGFR4 by FGF1 induced a sustained phosphorylation of extracellular signal ...
Cailliau, Katia, Browaeys-Poly, Edith, Vilain, Jean Pierre   +2 more
openaire   +2 more sources