Results 91 to 100 of about 111,873,328 (289)

The molecular mechanism of gemcitabine in inhibiting the HIF-1α/VEGFB/FGF2/FGFR1 signaling pathway for ovarian cancer treatment

Discover Oncology
Ovarian cancer is a common malignant tumor in women, exhibiting a certain sensitivity to chemotherapy drugs like gemcitabine (GEM). This study, through the analysis of ovarian cancer single-cell RNA sequencing (scRNA-seq) data and transcriptome data post-
Liangliang Wang, Shanshan Ma, Huiwen Su, Dandan Nie, Lihua Wang   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

, 2009
Supplementary Data from Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in ...
Michael G. Gartside (14889647), Ana Bengston (14892053), Pilar Hyder (15085092), Graham J. Mann (6174710), Huaibin Chen (15085080), Moosa Mohammadi (88381), Pamela M. Pollock (14871696), Boris C. Bastian (12883149), Laura M. Yudt (15085089), Candice L. Wellens (14889650), Ursula L. Harper (2817598), Jeffrey M. Trent (9110592), Jinghong Ma (1755838), Amy V. Curtis (15085086), John A. Curtin (9510637), Erica Riedesel (15085095), Sara A. Byron (8195817), Paul S. Meltzer (8423274), Omar A. Ibrahimi (15085083), Anna V. Eliseenkova (2351683)   +19 more
core   +1 more source

Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme

Developmental Biology, 2006
To determine the importance of fibroblast growth factor receptors (fgfrs) 1 and 2 in the metanephric mesenchyme, we generated conditional knockout mice (fgfr(Mes-/-)). Fgfr1(Mes-/-) and fgfr2(Mes-/-) mice develop normal-appearing kidneys. Deletion of both receptors (fgfr1/2(Mes-/-)) results in renal aplasia. Fgfr1/2(Mes-/-) mice develop a ureteric bud (
Poladia, Deepali Pitre, Kish, Kayle, Kutay, Benjamin, Hains, David, Kegg, Heather, Zhao, Haotian, Bates, Carlton M.   +6 more
openaire   +2 more sources

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. [PDF]

, 2005
Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans ...
Roberto Ronca, MITOLA, Stefania Maria Filomena, RUSNATI, Marco, Marco Rusnati, DELL'ERA, Patrizia, Stefania Mitola, Marco Presta, RONCA, Roberto, Emanuela Moroni, PRESTA, Marco, Patrizia Dell’Era, MORONI, Emanuela   +11 more
core   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Thrombin-Stimulated Proliferation of Cultured Human Synovial Fibroblasts Through Proteolytic Activation of Proteinase-Activated Receptor-1

Journal of Pharmacological Sciences, 2008
We examined the mechanism of thrombin on proliferation of synovial fibroblasts obtained from rheumatoid arthritis (RA). Thrombin concentration-dependently induced proliferation of synovial fibroblasts. Proliferation in response to thrombin (10 U /ml) was
Ikue Furuhashi, Kazuki Abe, Toshitsugu Sato, Hideo Inoue   +3 more
doaj   +1 more source

Angiogenesis-dependent and independent phases of intimal hyperplasia. [PDF]

, 2004
BACKGROUND: Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the
De Muinck, E, Ferrara, N, Simons, M, Khurana, R, Zhuang, Z, Martin, JF, Murakami, M, Zachary, I, Bhardwaj, S, Yla-Herttuala, S   +9 more
core  

Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud

Developmental Biology, 2004
Fibroblast growth receptors (FGFRs) consist of four signaling family members. Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney development. To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach.
Zhao, Haotian, Kegg, Heather, Grady, Sandy, Truong, Hoang-Trang, Robinson, Michael L., Baum, Michel, Bates, Carlton M.   +6 more
openaire   +2 more sources