Results 71 to 80 of about 111,873,328 (289)

Supplementary Figure 1 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells

, 2011
Supplementary Figure 1 from Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor ...
Joseph A. Knowles (15085014), Larissa Sweeny (15085017), Jason M. Warram (6640337), Tong Zhou (3770), Zhiyong Liu (160339), Yolanda E. Hartman (14995104), Eben L. Rosenthal (13847938)   +6 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Biology of FGFRL1, the fifth fibroblast growth factor receptor [PDF]

, 2010
FGFRL1 (fibroblast growth factor receptor like 1) is the most recently discovered member of the FGFR family. It contains three extracellular Ig-like domains similar to the classical FGFRs, but it lacks the protein tyrosine kinase domain and instead ...
Trueb, Beat, Beat Trueb, Trueb B
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Increase Fibroblast Activation Protein-α, but not Lowering of FGF Receptor and/or Co-Receptor, Causes Increase in Fibroblast Growth Factor-21 in T2D Independent on Diabetes Duration [PDF]

Ain Shams Medical Journal
Background: Diabetes mellitus is a major global public health issue. T2DM patients are associated with increased Fibroblast growth Factor 21 (FGF21).
Ghofran Kamel, Ahmed Alshawi
doaj   +1 more source

Global Developmental Gene Programing Involves a Nuclear Form of Fibroblast Growth Factor Receptor-1 (FGFR1). [PDF]

PLoS ONE, 2015
Genetic studies have placed the Fgfr1 gene at the top of major ontogenic pathways that enable gastrulation, tissue development and organogenesis. Using genome-wide sequencing and loss and gain of function experiments the present investigation reveals a ...
Christopher Terranova, Sridhar T Narla, Yu-Wei Lee, Jonathan Bard, Abhirath Parikh, Ewa K Stachowiak, Emmanuel S Tzanakakis, Michael J Buck, Barbara Birkaya, Michal K Stachowiak   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Impairment of sperm motility in mice with heterozygous deletion of fibroblast growth factor receptor 1 [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of heterozygous deletion of fibroblast growth factor receptor 1 (FGFR1) on reproductive function in congenital hypogonadotropic hypogonadism (CHH).
LI Chenyang, LI Ting, WANG Xi, NIE Min, WU Xueyan, MAO Jiangfeng, HAN Qin
doaj   +1 more source