Results 101 to 110 of about 6,340 (159)

Investigations into the stability of growth factor induced-vasculature and the effects of synthetic biomaterials on heart remodelling after myocardial infarction

, 2011
This work was based on the hypothesis that optimization of growth factor delivery rate and duration, combined with a biomaterial scaffold, could lead to an improved strategy for therapeutic neovascularization.
Dobner, Stephan
core  

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts

, 2004
The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence ...
Abraham, DJ, du Bois, R M, Denton, CP, Black, C M, Chen, YL, Chen, Y L, Chen, Y, Shi-Wen, X., Renzoni, E.A., Denton, C P, Shi-Wen, X, Leask, A., Pearson, J D, Xu, SW, Bou-Gharios, George, du Bois, RM, Xu, S W, Dashwood, M, Denton, C.P., Bou-Gharios, G., Renzoni, E A, Pearson, JD, Chen, Y., Abraham, D.J., Abraham, D J, Renzoni, EA, Black, CM, Dashwood, M., Eastwood, M, Leask, A, Eastwood, M., Black, C.M., Pearson, J., du Bois, R., Bou-Gharios, G   +34 more
core   +1 more source

Autocrine Fibroblast Growth Factor Receptor 1 Signaling Activates Lactate Dehydrogenase A-Aerobic Glycolysis for Advanced Human Prostate Tumor Growth

Prostate Cancer
Conclusion: Our data indicate autocrine FGF/FGFR1 signaling regulates aerobic glycolysis in PCa DU145 cells via LDHA, suggesting the potential of targeting FGFs/FGFRs-LDHA for the management of advanced PCa.
Xiaoming Xu, Li Wang, Huafeng Pan, Tingitng Gu, Zhongliang Cheng, Tianjun Peng, Jianting Zhang, Jiaren Pan   +7 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 1 [PDF]

, 2020
openaire   +1 more source

Fibroblast growth factor receptor (FGFR); fibroblast growth factor receptor 1 (FGFR1; CD331) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Engineering mammalian cells for detection and treatment of cardiac injury

Molecular Systems Biology
Early detection of myocardial abnormalities or other ischemic heart diseases is critical for effective treatment. Here, we aimed to engineer a cell-based system to sense cardiac troponin I (cTnI), an early marker of acute myocardial infarction (AMI), and
Yaqing Si, Yuxuan Fan, Leo Scheller, Bozhidar-Adrian Stefanov, Jian Lv, Zhihua Wang, Mingqi Xie, Martin Fussenegger   +7 more
doaj   +1 more source

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

, 2008
KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring in 10% to 30% and 26% to 80% of endometrial cancers, respectively.
Keenan, Jack, Goodfellow, Paul, Wellens, Candice, Gartside, Michael, Powell, Matthew, Pollock, Pamela, Byron, Sara, Mallon, Mary   +7 more
core   +1 more source

Control of cell division in the adult brain by heparan sulfates in fractones and vascular basement membranes

, 2010
Regulation of cell division in adult tissues and organs requires the coordination of growth factors at the surface of potentially-dividing cells in specific anatomic loci named germinal niches.
Frederic Mercier, Vanessa Douet
core  

FGFR1 protein level is associated with ER expression and prognosis in ER-positive breast cancer

Zhongguo aizheng zazhi, 2019
Background and purpose: Breast cancer is one of the most common malignancies in women. Endocrine therapy is one of the most important therapeutics in breast cancer systemic therapy.
王宇航, 宋全福, 吴俊强, 南丁阿比雅斯, 阿勒哈, 庞　达, 姜永冬   +6 more
doaj  

Fibroblast Growth Factor Receptor Function in Muscle Stem Cells

, 2018
Skeletal muscle has a remarkable ability to regenerate itself following injury and this is reliant upon a group of stem cells known as muscle stem cells Muscle stem cell dysfunction contributes to variety of muscle wasting diseases and insights into ...
Hackett, Tashi
core   +1 more source