Fibroblast Growth Factor Receptor Functions in Glioblastoma [PDF]
Cells, 2019 Glioblastoma is the most lethal brain cancer in adults, with no known cure. This cancer is characterized by a pronounced genetic heterogeneity, but aberrant activation of receptor tyrosine kinase signaling is among the most frequent molecular alterations
Ana Jimenez-Pascual +1 more
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Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer
Cells, 2018 Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis.
Navid Sobhani +8 more
doaj +4 more sources
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. [PDF]
Cytokine & Growth Factor Reviews, 2005 Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
M. Presta +5 more
semanticscholar +4 more sources
Fibroblast Growth Factor Receptor Signaling in Skin Cancers
Cells, 2019 Fibroblast growth factor (FGF)/Fibroblast growth factor receptor (FGFR) signaling regulates various cellular processes during the embryonic development and in the adult organism.
Malgorzata Czyz
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Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer
Open Biology, 2022 Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal development, tissue homeostasis, tumorigenesis and metastasis.
Chiara Francavilla
exaly +2 more sources
Fibroblast growth factor 10 attenuates advanced liver fibrosis through hepatocyte fibroblast growth factor receptor 2 signalling [PDF]
Clinical and Translational MedicineBackground Metabolic dysfunction–associated steatotic liver disease (MASLD) and advanced fibrotic stages are significant contributors to cirrhosis and liver‐related mortality, yet no therapies directly target fibrosis in the later stages of the disease ...
Xuanxin Yang +20 more
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Fibroblast growth factor receptors in breast cancer [PDF]
Tumor Biology, 2017 Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer.
Shuwei Wang, Zhongyang Ding
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Conceptualization of fibroblast growth factor receptor 1 targeting nanomedicines [PDF]
Exploration of Targeted Anti-tumor TherapyFibroblast growth factor receptor 1 (FGFR1) is crucial in the progression of various cancers, participating in the processes of cell proliferation, survival, and differentiation. FGFR1 plays a role in the resistance to immune checkpoint inhibitors (ICIs)
Yilin Ma +3 more
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Receptor Specificity of the Fibroblast Growth Factor Family* [PDF]
Journal of Biological Chemistry, 1996 Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns.
D. Ornitz +7 more
semanticscholar +3 more sources
Protein kinase B inhibitors enhance the sensitivity of translocated promoter region–fibroblast growth factor receptor 1 cells to fibroblast growth factor receptor 1 inhibitor-induced apoptosis [PDF]
Journal of International Medical ResearchObjective Fibroblast growth factor receptor 1 (FGFR1) inhibitors are considered effective for treating 8p11 myeloproliferative syndrome. However, targeting FGFR1 alone may be inadequate for patients with translocated promoter region (TPR)–FGFR1 ...
Mengyao Lv +5 more
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