Results 31 to 40 of about 230,861 (252)

Fibroblast growth factor receptor 3-IIIc mediates colorectal cancer growth and migration [PDF]

British Journal of Cancer, 2010
Deregulation of fibroblast growth factor receptor 3 (FGFR3) is involved in several malignancies. Its role in colorectal cancer has not been assessed before.Expression of FGFR3 in human colorectal tumour specimens was analysed using splice variant-specific real-time reverse transcriptase PCR assays.
Sonvilla, G, Allerstorfer, S, Heinzle, C, Stättner, S, Karner, J, Klimpfinger, M, Wrba, F, Fischer, H, Gauglhofer, C, Spiegl-Kreinecker, S, Grasl-Kraupp, B, Holzmann, K, Grusch, M, Berger, W, Marian, B   +14 more
openaire   +2 more sources

Molecular Confirmation of G1138A Mutation in FGFR gene in Achondroplasia

Journal of Nepal Medical Association, 2018
Introduction: Achondroplasia (ACH) is the most common form of skeletal dysplasia of genetic origin in humans which is characterized by disproportionate rhizomelic dwarfism.
Shyam Bahadur Khanal, Mitesh Shrestha, Hemanta Kumari Chaudhary, Smita Shrestha, Rohit Kumar Pokharel   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fibroblast Growth Factor Receptor 3 Mutations in Bladder Cancer: A Marker for Early-Stage Diagnosis

مجله كليه طب الكندي
Background: Bladder cancer (BC) ranks as the tenth most common cancer globally, with a high recurrence rate. It is primarily caused by abnormalities in the epithelial layer lining the bladder and is classified from non-muscle invasive bladder cancer
Hosam Elessawy, Omar F. Abdul‐Rasheed, Mohammed F. Alqanbar   +2 more
doaj   +1 more source

Fibroblast Growth Factor Receptor 3 (FGFR3)–Analyses of the S249C Mutation and Protein Expression in Primary Cervical Carcinomas

Analytical Cellular Pathology, 2001
Fibroblast growth factor receptor 3 (FGFR3) seems to play an inhibitory role in bone development, as activating mutations in the gene underlie disorders such as achondroplasia and thanatophoric dysplasia. Findings from multiple myeloma (MM) indicate that
Haiyan Dai, Ruth Holm, Gunnar B. Kristensen, Vera M. Abeler, Anne‐Lise Børresen‐Dale, Åslaug Helland   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Down-regulation of FGFR3 expression aggravates the damage of articular chondrocyte superficial zone cells in mice [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of fibroblast growth factor receptor 3 (FGFR3) on articular cartilage superficial zone cells (SPZCs). Methods C57 mice were randomly divided into two groups: a sham operated group (sham group) and a group of surgically
GUAN Yunbo, LI Chao, XU Cheng, SUN Xiaofei, BAI Xuedong, HE Qing, WANG Zuqiang
doaj   +1 more source

Ligand‐binding specificity of human fibroblast growth factor receptor‐3 IIIc [PDF]

FEBS Letters, 1997
Earlier studies indicated that human fibroblast growth factor receptor (FGFR)‐3 IIIc was activated equally well by both FGF‐1 and FGF‐2. In contrast, murine FGFR‐3 IIIc was preferentially activated by FGF‐1. To address this issue, we determined the ligand‐binding specificity of human FGFR‐3 IIIc in comparison with human FGFR‐1 IIIc.
Lin, Hsien-Yi, Kaplow, June, Jaye, Michael, Hayman, Michael J.   +3 more
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Fibroblast Growth Factor Receptor 3 Mutations in Bladder Tumors Correlate with Low Frequency of Chromosome Alterations

Neoplasia: An International Journal for Oncology Research, 2008
The aim of this study was to analyze the distribution of FGFR3 mutations in bladder tumors of different grade and stage and determine the relation of mutations to chromosomal alterations detected by comparative genomic hybridization (CGH).
Kerstin Junker, Johanna M.M. van Oers, Ellen C. Zwarthoff, Ines Kania, Joerg Schubert, Arndt Hartmann   +5 more
doaj   +1 more source