Results 271 to 280 of about 343,520 (320)

Integrin α5β1 mediates the inhibitory effects of vasoinhibin on angiogenesis and vascular permeability. [PDF]

J Biol Chem
Zamora M, Clapp C, Martínez de la Escalera G, Robles JP.   +3 more
europepmc   +1 more source

Reprogramming M2b Macrophages via GPX1 Activation by Selenium Nanoparticles Attenuates Lupus Nephritis

Advanced Science, EarlyView.
SeZM NPs selectively target M2b macrophages through mannose–MRC1 (CD206) recognition, enhance GPX1 biosynthesis, and suppress mitochondrial ROS generation, oxidative stress, and JAK–STAT signaling. This dual regulation reduces pro‐inflammatory cytokine release, limits immune cell infiltration and fibrosis, and preserves renal function, providing a ...
Haoran Lv, Guanning Huang, Hongyu Li, Hanzhi Liang, Huajing Peng, Kefei Wu, Wenfang Chen, Dandan Zhang, Kexin Ma, Yufei Du, Siweier Luo, Yi Zhou, Haiping Mao, Wei Chen, Tianfeng Chen, Yiming Zhou, Qinghua Liu   +16 more
wiley   +1 more source

Use of a new micropattern tape method to detect chirality shifts in differentiating C2C12 cells. [PDF]

PLoS One
Weng Q, Osaka T, Onoe H, Yoshida K, Kuroda Y, Matsuo K, Kawaai K.   +6 more
europepmc   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Dual Phosphorylation of STAT1 at Y701/S727 by TNFα Drives AIM2-Mediated PANoptosis of Renal Tubular Epithelial Cells and Fibrotic Progression in Renal Allografts. [PDF]

Int J Biol Sci
Han Q, Liu J, Zhang J, Shen Q, Zhang J, Fei S, Chen H, Sun L, Huang Z, Han Z, Tao J, Gu M, Ju X, Tan R.   +13 more
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Potential phosphorylation of Liprin-α1 at threonine 701 regulates integrin-mediated cell motility. [PDF]

PLoS One
Ramella M, Brambilla D, Surini S, Tonoli D, Ribolla LM, de Curtis I.   +5 more
europepmc   +1 more source

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-β/Smad and Wnt/β-Catenin Pathways. [PDF]

Pharmaceuticals (Basel)
Guo Q, Peng L, Zhang J, Hu J, Wang Y, Wei J, Zhang Z.   +6 more
europepmc   +1 more source