Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry
This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou+4 more
wiley +2 more sources
Digoxin promotes anoikis of circulating cancer cells by targeting Na<sup>+</sup>/K<sup>+</sup>-ATPase α3-isoform. [PDF]
Numata Y+9 more
europepmc +1 more source
Nanostructured Biomaterial‐Based Approaches to Support Induced Pluripotent Stem Cell Differentiation
Induced pluripotent stem cells (iPSCs), reprogrammed from adult somatic cells, represent an innovative approach for regenerative medicine and biomedical applications. This review highlights the importance of nanostructured biomaterials, utilized as delivery systems or scaffolds, in supporting iPSC differentiation and fate through structural and ...
Beatriz A. B. R. Passos+2 more
wiley +1 more source
Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou+7 more
wiley +1 more source
Gene Expression of Extracellular Matrix Proteins, MMPs, and TIMPs in Post-Operative Tissues of Chronic Rhinosinusitis Patients. [PDF]
Vaitkus Z+6 more
europepmc +1 more source
Premetastatic niche mechanics and organotropism in breast cancer. [PDF]
Libring S, Reinhart-King CA.
europepmc +1 more source
Effects of Brimonidine, Latanoprost, and Omidenepag on Tunicamycin-Induced Endoplasmic Reticulum Stress and Fibrosis in Human Trabecular Meshwork Cells. [PDF]
Liu M, Honjo M, Yamagishi R, Aihara M.
europepmc +1 more source
Objective Scleroderma is a life‐threatening autoimmune disease characterized by inflammation, tissue remodeling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally induced dermal fibrosis to determine its potential role and therapeutic implications.
Angela Y. Y. Tam+12 more
wiley +1 more source
Pirfenidone Alleviates Against Fine Particulate Matter-Induced Pulmonary Fibrosis Modulating via TGF-β1/TAK1/MKK3/p38 MAPK Signaling Pathway in Rats. [PDF]
Sung JS+8 more
europepmc +1 more source
The authors present a new technique for 3D culture of mammalian cells with the support of a microfiber‐based network of fibronectin (FN)‐functionalized recombinant silk. This feasible 2‐step method results in highly viable free‐floating 3D cultures with tissue‐mimicking morphology.
Astrid Källén+4 more
wiley +1 more source