Results 241 to 250 of about 1,024,087 (311)

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases. [PDF]

Mol Med
Mina IK, Hussain Y, Siwy J, Catanese L, Rupprecht H, Beige J, Staessen JA, Metzger J, Persson F, Rossing P, Delles C, Schanstra JP, Bannaga A, Vlahou A, Mischak H, Arasaradnam RP, Latosinska A.   +16 more
europepmc   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Defective Ribosome Biogenesis Drives Tubular Senescence and Renal Fibrosis via IRBC-p53 Activation. [PDF]

Cells
Song K, Su H.
europepmc   +1 more source

Evaluating periportal fibrosis in schistosomiasis mansoni using the ELF [Enhanced Liver Fibrosis] score: A pilot study. [PDF]

PLoS Negl Trop Dis
Thorp RD, Batista AD, Mariz CA, de Araújo LRMG, Diniz GTN, Barreto AVMS, de Morais CNL, Silva PCV, Domingues ALC, Lopes EP.   +9 more
europepmc   +1 more source

Itaconate as the endogenous brake of proinflammatory macrophage activation alleviates inflammation in liver fibrogenesis. [PDF]

Hepatol Commun
Zhang K, Li T, Liu W, Li W, Yang L, Chang N, Li L.   +6 more
europepmc   +1 more source