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The pathogenesis of pulmonary fibrosis: Is there a fibrosis gene?

The International Journal of Biochemistry & Cell Biology, 1997
Interstitial fibrosis is seen in the lung in response to a variety of insults, and often appears stereotypical in terms of its clinical and pathological features. However, exposure to a known aetiological factor does not always lead to fibrosis. For example in bleomycin-induced pulmonary fibrosis, a wide variation in response is seen both in humans and
R P, Marshall   +2 more
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Cystic Fibrosis

Pathology Patterns Reviews, 2003
On a daily basis, pathologists examine the fundamental basis of human diseases using morphologic, immunologic, and molecular techniques. Cystic fibrosis (CF), as a clinically heterogeneous disease, exemplifies the complex challenges of genetic diseases for the pathologist who attempts to explain the mechanisms of disease and provide rationale for ...
Myra J, Lewis   +3 more
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Liver fibrosis

Springer Seminars in Immunopathology, 1999
Knowledge on the development and progression of liver fibrosis has grown exponentially in the past decade. At present, liver fibrogenesis is referred to as a dynamic process involving complex cellular and molecular mechanisms, resulting from the chronic activation of the tissue repair mechanisms that follows reiterated liver tissue injury.
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Cystic fibrosis

Current Problems in Pediatrics, 1991
The past few years have seen amazing progress in our understanding of the underlying cellular and molecular bases of CF. This new understanding has raised hopes for improved treatments in the very near future. These new treatments are expected to improve even further the prognosis for survival in this disorder, which has improved nearly 1 year for ...
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Fibrosis with emphysema

Histopathology, 2010
Wright J L, Tazelaar H D & Churg A (2011) Histopathology 58, 517–524
Fibrosis with emphysemaThe concept of fibrosis with emphysema is confused by the existence of two very different clinical/pathological scenarios: first, cases in which a diffuse fibrosing interstitial pneumonia, most commonly usual interstitial pneumonia (UIP), occurs in a patient
Joanne L, Wright   +2 more
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Cystic fibrosis

Nature Reviews Disease Primers
Marcus A Mall   +2 more
exaly   +3 more sources

Cystic fibrosis

Lung, 1994
While the care of cystic fibrosis (CF) patients has been mainly the province of pediatricians, great improvements in the therapy and life span of CF patients often results in their transition to care by adult physicians. In this review of CF, we begin with an overview of the epidemiology and genetics of the disease, with a discussion of the recently ...
M R, Bye, J M, Ewig, L M, Quittell
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Retroperitoneal fibrosis

Urologic Radiology, 1990
Retroperitoneal fibrosis is idiopathic in two thirds of cases and is found most commonly as an isolated fibrotic plaque centered over the lower lumbar spine and entrapping one or both ureters. It has been postulated that the fibrosis in the idiopathic cases results from a hypersensitivity reaction to antigens leaking into the retroperitoneum from ...
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Cystic fibrosis

Disease-a-Month, 1993
Cystic fibrosis, an autosomal recessive disorder, is the most common genetic disease of Caucasians. One in 25 Caucasians are carriers of the gene. The gene is found far less commonly in other races. There are over 230 different alleles of the gene, located on the 7th chromosome.
M L, Aitken, S B, Fiel
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Intestinal fibrosis

Molecular Aspects of Medicine, 2019
Extensive tissue fibrosis is the end-stage process of a number of chronic conditions affecting the gastrointestinal tract, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), ulcerative jejunoileitis, and radiation enteritis.
Marco Vincenzo Lenti   +1 more
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